Synthesis of raloxifene-like quinoxaline derivatives by intramolecular electrophilic cyclization with disulfides

The intramolecular electrophilic cyclization of alkynes with disulfides to form thieno[2,3-b]quinoxaline structures and to introduce thioether substituents afforded quinoxaline derivatives (7a-7d, 8a-8d). Among obtained eight derivatives, the raloxifene analogues (7c, 8b) showed specifically high cy...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2023-09, Vol.93, p.129415-129415, Article 129415
Hauptverfasser:	Umezu, Yuhi, Horiyama, Eito, Nakai, Yuto, Ninomiya, Masayuki, Nishina, Atsuyoshi, Koketsu, Mamoru
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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