Weak-hyperactive hippocampal CA1 neurons in the prodromal stage of Alzheimer's disease in hybrid AppNL-G-F/NL-G-F × Thy1-GCaMP6s+/− mice suggest disrupted plasticity

This study investigated the impact of familial Alzheimer's disease (AD)-linked amyloid precursor protein (App) mutations on hippocampal CA1 neuronal activity and function at an early disease stage in AppNL-G-F/NL-G-F × Thy1-GCaMP6s+/− (A-TG) mice using calcium imaging. Longitudinal assessment o...

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Veröffentlicht in:	Neurobiology of aging 2023-10, Vol.130, p.154-171
Hauptverfasser:	Inayat, Samsoon, McAllister, Brendan B., Chang, HaoRan, Lacoursiere, Sean G., Whishaw, Ian Q., Sutherland, Robert J., Mohajerani, Majid H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Air induced running task Alzheimer's disease AppNL-G-F Calcium imaging Morris water task Thy1-GCaMP6s
Online-Zugang:	Volltext
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