How the cGAS–STING system links inflammation and cognitive decline

How the cGAS–STING system links inflammation and cognitive decline

When DNA is misplaced inside cells, the cGAS–STING molecular system triggers inflammation. It emerges that stimulation of this mechanism in microglial cells of the brain during ageing contributes to cognitive decline. Misplaced DNA triggers inflammation in the brain’s microglial cells.

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Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 2023-08, Vol.620 (7973), p.280-282
1. Verfasser: Eggen, Bart J. L.
Format: Artikel
Sprache:eng
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Humanities and Social Sciences
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News And Views
Science
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Zusammenfassung:When DNA is misplaced inside cells, the cGAS–STING molecular system triggers inflammation. It emerges that stimulation of this mechanism in microglial cells of the brain during ageing contributes to cognitive decline. Misplaced DNA triggers inflammation in the brain’s microglial cells.
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-023-02240-1