GPCR activation and GRK2 assembly by a biased intracellular agonist

Phosphorylation of G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) desensitizes G-protein signalling and promotes arrestin signalling, which is also modulated by biased ligands 1 – 6 . The molecular assembly of GRKs on GPCRs and the basis of GRK-mediated biased signalling remain largely u...

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Veröffentlicht in:	Nature (London) 2023-08, Vol.620 (7974), p.676-681
Hauptverfasser:	Duan, Jia, Liu, Heng, Zhao, Fenghui, Yuan, Qingning, Ji, Yujie, Cai, Xiaoqing, He, Xinheng, Li, Xinzhu, Li, Junrui, Wu, Kai, Gao, Tianyu, Zhu, Shengnan, Lin, Shi, Wang, Ming-Wei, Cheng, Xi, Yin, Wanchao, Jiang, Yi, Yang, Dehua, Xu, H. Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/535/1258/1259 631/80/86/820 96/95 Addictive behaviors Arrestin Arrestins - metabolism Assembly b-Adrenergic-receptor kinase Binding G protein-coupled receptors G-Protein-Coupled Receptor Kinase 2 - biosynthesis G-Protein-Coupled Receptor Kinase 2 - chemistry G-Protein-Coupled Receptor Kinase 2 - metabolism GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism Humanities and Social Sciences Kinases Ligands multidisciplinary Neurotensin Peptides Phosphorylation Piperidines - metabolism Protein Binding Proteins Quinazolines - metabolism Receptors Receptors, G-Protein-Coupled - metabolism Receptors, Neurotensin - metabolism Recruitment Science Science (multidisciplinary) Signal Transduction
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