CRISPR/Cas12a-Powered EC/FL Dual-Mode Controlled-Release Homogeneous Biosensor for Ultrasensitive and Cross-Validated Detection of Messenger Ribonucleic Acid

Accurate detection of cancer-associated mRNAs is beneficial to early diagnosis and potential treatment of cancer. Herein, for the first time, we developed a novel CRISPR/Cas12a-powered electrochemical/fluorescent (EC/FL) dual-mode controlled-release homogeneous biosensor for mRNA detection. A functi...

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Veröffentlicht in:	Analytical chemistry (Washington) 2023-08, Vol.95 (32), p.12122-12130
Hauptverfasser:	Dong, Jiangbo, Li, Xinyao, Zhou, Shiying, Liu, Yin, Deng, Liyuan, Chen, Jian, Hou, Jingzhou, Hou, Changjun, Huo, Danqun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Analytical chemistry Biosensors Cancer Chemistry Controlled release CRISPR Diagnosis Electrochemistry Electrostatic properties Fluorescence Iron oxides Lysates Magnetic separation Methylene blue mRNA Nicking endonuclease Ribonucleic acid RNA Single-stranded DNA Survivin
Online-Zugang:	Volltext
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