Platinum(iv) combo prodrugs containing cyclohexane-1R,2R-diamine, valproic acid, and perillic acid as a multiaction chemotherapeutic platform for colon cancer

The complex [PtCl2(cyclohexane-1R,2R-diamine)] has been combined in a Pt(iv) molecule with two different bioactive molecules (i.e., the histone deacetylase inhibitor 2-propylpentanoic acid or valproic acid, VPA, and the potential antimetastatic molecule 4-isopropenylcyclohexene-1-carboxylic acid or...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2023-08, Vol.52 (32), p.11349-11360
Hauptverfasser:	Gabano, Elisabetta, Marzia Bruna Gariboldi, Marras, Emanuela, Barbato, Francesca, Ravera, Mauro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antiproliferatives Biological properties Carboxylic acids Cell cycle Colorectal cancer Cyclohexane Diamines Histones Matrix metalloproteinases Reagents
Online-Zugang:	Volltext
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