Severe persistent neurotoxicity associated with CAR T therapy in children

Summary CD19‐directed chimeric antigen receptor (CAR) T‐cell therapy is an important therapy for relapsed or refractory acute lymphoblastic leukaemia, but its use carries the risk of immune effector cell‐associated neurotoxicity syndrome (ICANS). In children, severe ICANS is almost universally repor...

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Veröffentlicht in:	British journal of haematology 2023-11, Vol.203 (4), p.651-655
Hauptverfasser:	Andrew, Eden C., Hughes, David, Gilsenan, Maddie, Mignone, Cristina, Khaw, Seong Lin, Wang, Stacie Shiqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia CAR T‐cell therapy CD19 antigen Cell therapy Central nervous system Children Chimeric antigen receptors Cytokines Hematology immune effector cell‐associated neurotoxicity syndrome immunotherapy leukaemia Neurotoxicity
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