Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity

SMARCA2 is an attractive synthetic lethality target for human cancers with SMARCA4 deficiency. Herein, we report the design, synthesis, and biological evaluation of selective SMARCA2 protein degraders developed using the proteolysis targeting chimera (PROTAC) technology. Our efforts have led to the...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2023-08, Vol.66 (15), p.10761-10781
Hauptverfasser:	Yang, Lin, Tu, Wenbin, Huang, Liyue, Miao, Bukeyan, Kaneshige, Atsunori, Jiang, Wei, Leng, Lingying, Wang, Meilin, Wen, Bo, Sun, Duxin, Wang, Shaomeng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!