Intracerebral Hemorrhage-Induced Brain Injury: the Role of Lysosomal-Associated Transmembrane Protein 5

Intracerebral hemorrhage (ICH) is a lethal stroke with high mortality or disability. However, effective therapy for ICH damage is generally lacking. Previous investigations have suggested that lysosomal protein transmembrane 5 (LAPTM5) is involved in various pathological processes, including autopha...

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Veröffentlicht in:	Molecular neurobiology 2023-12, Vol.60 (12), p.7060-7079
Hauptverfasser:	Hua, Wei, Ma, Shuainan, Pang, Yuxin, Liu, Qi, Wang, Yueying, Liu, Zhiyi, Zhao, Nan, Ren, Naixin, Jin, Sinan, Wang, Benshuai, Song, Yuejia, Qi, Jiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis Astrocytes Autophagy Biomedical and Life Sciences Biomedicine Blood-brain barrier Brain Injuries - complications Brain Injuries - genetics Brain Injuries - pathology Brain injury Cell Biology Cell culture Cerebral Hemorrhage - pathology Collagenase Down-regulation Edema Hematoma Hemoglobin Hemoglobins Hemorrhage Inflammation Kinases LAPTm5 protein Lysosomal protein Lysosomes - metabolism Membrane permeability Mice Microglia Neurobiology Neurodegeneration Neurological diseases Neurology Neurosciences NF-kappa B - metabolism NF-κB protein Proteins Stroke Therapeutic targets Transmembrane proteins Traumatic brain injury
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