Exploring the presence of bovine leukemia virus among breast cancer tumors in a rural state
Purpose The bovine leukemia virus (BLV) is a deltaretrovirus that causes malignant lymphoma and lymphosarcomas in cattle globally and has high prevalence among large scale U.S. dairy herds. Associations between presence of BLV DNA in human mammary tissue and human breast cancer incidence have been r...
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| Veröffentlicht in: | Breast cancer research and treatment 2023-11, Vol.202 (2), p.325-334 |
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| creator | Amato, Stas Ramsey, Jon Ahern, Thomas P. Rovnak, Joel Barlow, John Weaver, Donald Eyasu, Lud Singh, Rohit Cintolo-Gonzalez, Jessica |
| description | Purpose
The bovine leukemia virus (BLV) is a deltaretrovirus that causes malignant lymphoma and lymphosarcomas in cattle globally and has high prevalence among large scale U.S. dairy herds. Associations between presence of BLV DNA in human mammary tissue and human breast cancer incidence have been reported. We sought to estimate the prevalence of BLV DNA in breast cancer tissue samples in a rural state with an active dairy industry.
Methods
We purified genomic DNA from 56 fresh-frozen breast cancer tissue samples (51 tumor samples, 5 samples representing adjacent normal breast tissue) banked between 2016 and 2019. Using nested PCR assays, multiple BLV
tax
sequence primers and primers for the long terminal repeat (LTR) were used to detect BLV DNA in tissue samples and known positive control samples, including the permanently infected fetal lamb kidney cell line (FLK-BLV) and blood from BLV positive cattle.
Results
The median age of patients from which samples were obtained at the time of treatment was 60 (40–93) and all were female. Ninety percent of patients had invasive ductal carcinoma. The majority were poorly differentiated (60%). On PCR assay, none of the tumor samples tested positive for BLV DNA, despite having consistent signals in positive controls.
Conclusion
We did not find BLV DNA in fresh-frozen breast cancer tumors from patients presenting to a hospital in Vermont. Our findings suggest a low prevalence of BLV in our patient population and a need to reevaluate the association between BLV and human breast cancer. |
| doi_str_mv | 10.1007/s10549-023-07061-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2844091222</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A765726098</galeid><sourcerecordid>A765726098</sourcerecordid><originalsourceid>FETCH-LOGICAL-c517t-28afe908ca08f922e1d00ab240e19bce6702a2cf6f3a6bd45d03426a7ba30f6b3</originalsourceid><addsrcrecordid>eNp9kU9rFTEUxYMo9ln9Ai4kIIibqTeZmWRmWUr9AwU3unIR7mRu-lJnJs8kU-q3N89XrRWRLC6E3zmcew9jzwWcCAD9Jglom74CWVegQYmqecA2otV1paXQD9kGhNKV6kAdsScpXQFAr6F_zI5q3QoNUm_Yl_Ob3RSiXy553hLfRUq0WOLB8SFc-4X4ROtXmj3yax_XxHEOhR0iYcrcYmEjz-scYuJ-4cjjGnHiKWOmp-yRwynRs9t5zD6_Pf909r66-Pjuw9npRWVLilzJDh310FmEzvVSkhgBcJANkOgHS6okRWmdcjWqYWzaEepGKtQD1uDUUB-z1wffXQzfVkrZzD5ZmiZcKKzJyK5poBdSyoK-_Au9CmtcSrpCqVZ15XL9HXWJExm_uJAj2r2pOdWq1VJB3xXq5B9UeWM5lw0LOV_-7wle_SHYEk55m8K0Zh-WdB-UB9DGkFIkZ3bRzxi_GwFmX705VG9K9eZn9aYpohe3q63DTONvya-uC1AfgLTb903xbvf_2P4AlNy25w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2865687219</pqid></control><display><type>article</type><title>Exploring the presence of bovine leukemia virus among breast cancer tumors in a rural state</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Amato, Stas ; Ramsey, Jon ; Ahern, Thomas P. ; Rovnak, Joel ; Barlow, John ; Weaver, Donald ; Eyasu, Lud ; Singh, Rohit ; Cintolo-Gonzalez, Jessica</creator><creatorcontrib>Amato, Stas ; Ramsey, Jon ; Ahern, Thomas P. ; Rovnak, Joel ; Barlow, John ; Weaver, Donald ; Eyasu, Lud ; Singh, Rohit ; Cintolo-Gonzalez, Jessica</creatorcontrib><description>Purpose
The bovine leukemia virus (BLV) is a deltaretrovirus that causes malignant lymphoma and lymphosarcomas in cattle globally and has high prevalence among large scale U.S. dairy herds. Associations between presence of BLV DNA in human mammary tissue and human breast cancer incidence have been reported. We sought to estimate the prevalence of BLV DNA in breast cancer tissue samples in a rural state with an active dairy industry.
Methods
We purified genomic DNA from 56 fresh-frozen breast cancer tissue samples (51 tumor samples, 5 samples representing adjacent normal breast tissue) banked between 2016 and 2019. Using nested PCR assays, multiple BLV
tax
sequence primers and primers for the long terminal repeat (LTR) were used to detect BLV DNA in tissue samples and known positive control samples, including the permanently infected fetal lamb kidney cell line (FLK-BLV) and blood from BLV positive cattle.
Results
The median age of patients from which samples were obtained at the time of treatment was 60 (40–93) and all were female. Ninety percent of patients had invasive ductal carcinoma. The majority were poorly differentiated (60%). On PCR assay, none of the tumor samples tested positive for BLV DNA, despite having consistent signals in positive controls.
Conclusion
We did not find BLV DNA in fresh-frozen breast cancer tumors from patients presenting to a hospital in Vermont. Our findings suggest a low prevalence of BLV in our patient population and a need to reevaluate the association between BLV and human breast cancer.</description><identifier>ISSN: 0167-6806</identifier><identifier>ISSN: 1573-7217</identifier><identifier>EISSN: 1573-7217</identifier><identifier>DOI: 10.1007/s10549-023-07061-4</identifier><identifier>PMID: 37517027</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Bovine leukosis ; Breast ; Breast cancer ; Breast Neoplasms - epidemiology ; Breast Neoplasms - genetics ; Cancer ; Cancer research ; Cattle ; Dairy cattle ; Dairy industry ; Deoxyribonucleic acid ; DNA ; DNA, Viral - genetics ; Epidemiology ; Female ; Fetuses ; Genetic aspects ; Humans ; Leukemia ; Leukemia Virus, Bovine - genetics ; Long terminal repeat ; Lymphoma ; Mammary Neoplasms, Animal ; Medicine ; Medicine & Public Health ; Non-Hodgkin's lymphomas ; Oncology ; Patients ; Polymerase chain reaction ; Sheep - genetics ; Tumors</subject><ispartof>Breast cancer research and treatment, 2023-11, Vol.202 (2), p.325-334</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-28afe908ca08f922e1d00ab240e19bce6702a2cf6f3a6bd45d03426a7ba30f6b3</citedby><cites>FETCH-LOGICAL-c517t-28afe908ca08f922e1d00ab240e19bce6702a2cf6f3a6bd45d03426a7ba30f6b3</cites><orcidid>0000-0003-0572-5265</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10549-023-07061-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10549-023-07061-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37517027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amato, Stas</creatorcontrib><creatorcontrib>Ramsey, Jon</creatorcontrib><creatorcontrib>Ahern, Thomas P.</creatorcontrib><creatorcontrib>Rovnak, Joel</creatorcontrib><creatorcontrib>Barlow, John</creatorcontrib><creatorcontrib>Weaver, Donald</creatorcontrib><creatorcontrib>Eyasu, Lud</creatorcontrib><creatorcontrib>Singh, Rohit</creatorcontrib><creatorcontrib>Cintolo-Gonzalez, Jessica</creatorcontrib><title>Exploring the presence of bovine leukemia virus among breast cancer tumors in a rural state</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><addtitle>Breast Cancer Res Treat</addtitle><description>Purpose
The bovine leukemia virus (BLV) is a deltaretrovirus that causes malignant lymphoma and lymphosarcomas in cattle globally and has high prevalence among large scale U.S. dairy herds. Associations between presence of BLV DNA in human mammary tissue and human breast cancer incidence have been reported. We sought to estimate the prevalence of BLV DNA in breast cancer tissue samples in a rural state with an active dairy industry.
Methods
We purified genomic DNA from 56 fresh-frozen breast cancer tissue samples (51 tumor samples, 5 samples representing adjacent normal breast tissue) banked between 2016 and 2019. Using nested PCR assays, multiple BLV
tax
sequence primers and primers for the long terminal repeat (LTR) were used to detect BLV DNA in tissue samples and known positive control samples, including the permanently infected fetal lamb kidney cell line (FLK-BLV) and blood from BLV positive cattle.
Results
The median age of patients from which samples were obtained at the time of treatment was 60 (40–93) and all were female. Ninety percent of patients had invasive ductal carcinoma. The majority were poorly differentiated (60%). On PCR assay, none of the tumor samples tested positive for BLV DNA, despite having consistent signals in positive controls.
Conclusion
We did not find BLV DNA in fresh-frozen breast cancer tumors from patients presenting to a hospital in Vermont. Our findings suggest a low prevalence of BLV in our patient population and a need to reevaluate the association between BLV and human breast cancer.</description><subject>Animals</subject><subject>Bovine leukosis</subject><subject>Breast</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - genetics</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cattle</subject><subject>Dairy cattle</subject><subject>Dairy industry</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Viral - genetics</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fetuses</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia Virus, Bovine - genetics</subject><subject>Long terminal repeat</subject><subject>Lymphoma</subject><subject>Mammary Neoplasms, Animal</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Non-Hodgkin's lymphomas</subject><subject>Oncology</subject><subject>Patients</subject><subject>Polymerase chain reaction</subject><subject>Sheep - genetics</subject><subject>Tumors</subject><issn>0167-6806</issn><issn>1573-7217</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU9rFTEUxYMo9ln9Ai4kIIibqTeZmWRmWUr9AwU3unIR7mRu-lJnJs8kU-q3N89XrRWRLC6E3zmcew9jzwWcCAD9Jglom74CWVegQYmqecA2otV1paXQD9kGhNKV6kAdsScpXQFAr6F_zI5q3QoNUm_Yl_Ob3RSiXy553hLfRUq0WOLB8SFc-4X4ROtXmj3yax_XxHEOhR0iYcrcYmEjz-scYuJ-4cjjGnHiKWOmp-yRwynRs9t5zD6_Pf909r66-Pjuw9npRWVLilzJDh310FmEzvVSkhgBcJANkOgHS6okRWmdcjWqYWzaEepGKtQD1uDUUB-z1wffXQzfVkrZzD5ZmiZcKKzJyK5poBdSyoK-_Au9CmtcSrpCqVZ15XL9HXWJExm_uJAj2r2pOdWq1VJB3xXq5B9UeWM5lw0LOV_-7wle_SHYEk55m8K0Zh-WdB-UB9DGkFIkZ3bRzxi_GwFmX705VG9K9eZn9aYpohe3q63DTONvya-uC1AfgLTb903xbvf_2P4AlNy25w</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Amato, Stas</creator><creator>Ramsey, Jon</creator><creator>Ahern, Thomas P.</creator><creator>Rovnak, Joel</creator><creator>Barlow, John</creator><creator>Weaver, Donald</creator><creator>Eyasu, Lud</creator><creator>Singh, Rohit</creator><creator>Cintolo-Gonzalez, Jessica</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0572-5265</orcidid></search><sort><creationdate>20231101</creationdate><title>Exploring the presence of bovine leukemia virus among breast cancer tumors in a rural state</title><author>Amato, Stas ; 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The bovine leukemia virus (BLV) is a deltaretrovirus that causes malignant lymphoma and lymphosarcomas in cattle globally and has high prevalence among large scale U.S. dairy herds. Associations between presence of BLV DNA in human mammary tissue and human breast cancer incidence have been reported. We sought to estimate the prevalence of BLV DNA in breast cancer tissue samples in a rural state with an active dairy industry.
Methods
We purified genomic DNA from 56 fresh-frozen breast cancer tissue samples (51 tumor samples, 5 samples representing adjacent normal breast tissue) banked between 2016 and 2019. Using nested PCR assays, multiple BLV
tax
sequence primers and primers for the long terminal repeat (LTR) were used to detect BLV DNA in tissue samples and known positive control samples, including the permanently infected fetal lamb kidney cell line (FLK-BLV) and blood from BLV positive cattle.
Results
The median age of patients from which samples were obtained at the time of treatment was 60 (40–93) and all were female. Ninety percent of patients had invasive ductal carcinoma. The majority were poorly differentiated (60%). On PCR assay, none of the tumor samples tested positive for BLV DNA, despite having consistent signals in positive controls.
Conclusion
We did not find BLV DNA in fresh-frozen breast cancer tumors from patients presenting to a hospital in Vermont. Our findings suggest a low prevalence of BLV in our patient population and a need to reevaluate the association between BLV and human breast cancer.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37517027</pmid><doi>10.1007/s10549-023-07061-4</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0572-5265</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Bovine leukosis Breast Breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - genetics Cancer Cancer research Cattle Dairy cattle Dairy industry Deoxyribonucleic acid DNA DNA, Viral - genetics Epidemiology Female Fetuses Genetic aspects Humans Leukemia Leukemia Virus, Bovine - genetics Long terminal repeat Lymphoma Mammary Neoplasms, Animal Medicine Medicine & Public Health Non-Hodgkin's lymphomas Oncology Patients Polymerase chain reaction Sheep - genetics Tumors |
| title | Exploring the presence of bovine leukemia virus among breast cancer tumors in a rural state |
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