Activation of receptor‐interacting protein 3‐mediated necroptosis accelerates periodontitis in mice

Objective To investigate the involvement and role of receptor‐interacting protein 3 (RIP3)‐mediated necroptosis in periodontitis. Methods A periodontitis murine model was established by oral infection with Porphyromonas gingivalis, and activation of necroptosis pathway was identified by immunohistoc...

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Veröffentlicht in:	Oral diseases 2024-05, Vol.30 (4), p.2485-2496
Hauptverfasser:	Yue, Yuan, Chan, Weicheng, Zhang, Jing, Liu, Jie, Wang, Min, Hao, Liang, Wang, Jiajia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar bone Alveolar Bone Loss - metabolism Alveolar Bone Loss - pathology Animal models Animals Bacteroidaceae Infections - metabolism Bone loss Cell death Cell Line Cell viability Cytokines Cytokines - metabolism Disease Models, Animal Gene expression Gene Knockdown Techniques Gum disease Histology Immunofluorescence Immunohistochemistry Inflammation Kinases Lipopolysaccharides Male MAP kinase Mice Mice, Inbred C57BL MLKL Necroptosis Oral infection Osteoclastogenesis Periodontal ligament Periodontal Ligament - metabolism Periodontal Ligament - pathology Periodontics Periodontitis Periodontitis - metabolism Periodontitis - pathology Phosphorylation Polymerase chain reaction Porphyromonas gingivalis Protein Kinases - genetics Protein Kinases - metabolism Proteins Receptor-Interacting Protein Serine-Threonine Kinases - genetics Receptor-Interacting Protein Serine-Threonine Kinases - metabolism RIP3 Signal transduction siRNA
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