Delivering on Cell-Selective Protein Degradation Using Chemically Tailored PROTACs

PROTACs (Proteolysis-Targeting Chimeras) have emerged as a groundbreaking class of chemical tools that facilitate the degradation of target proteins by leveraging the ubiquitin-proteasome system (UPS). However, the effective utilization of PROTACs in chemical biology studies and therapeutics encount...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2023-10, Vol.24 (19), p.e202300413-e202300413
Hauptverfasser:	Yao, Rui, Luo, Tianli, Wang, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodegradation Chimeras Degradation External stimuli In vivo methods and tests Nanoparticles Proteasomes Proteins Proteolysis Ubiquitin
Online-Zugang:	Volltext
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