Discovery of Novel 1,2,3,4-Tetrahydrobenzofuro[2,3‑c]pyridine Histone Deacetylase Inhibitors for Efficient Treatment of Hepatocellular Carcinoma

The development of histone deacetylase (HDAC) inhibitors for treating hematologic malignancies has been widely investigated, while their role in hepatocellular carcinoma (HCC) remains unexplored. In this study, we employed a scaffold-hopping design and a multicomponent synthesis approach to develop...

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Veröffentlicht in:	Journal of medicinal chemistry 2023-08, Vol.66 (15), p.10791-10807
Hauptverfasser:	Lai, Zhencheng, Ni, Hao, Hu, Xueping, Cui, Sunliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Benzofurans - chemistry Benzofurans - pharmacology Benzofurans - therapeutic use Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Proliferation Histone Deacetylase 1 - metabolism Histone Deacetylase Inhibitors - chemistry Histone Deacetylase Inhibitors - pharmacology Histone Deacetylase Inhibitors - therapeutic use Humans Liver Neoplasms - pathology Molecular Docking Simulation Pyridines - chemistry Pyridines - pharmacology Pyridines - therapeutic use
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