Iron regulates chondrocyte phenotype in haemophilic cartilage through the PTEN/PI3 K/AKT/FOXO1 pathway

Our previous study demonstrated that iron overload could lead to haemophilic cartilage destruction by changing chondrocyte phenotype. This change was caused by iron's effect on chondrocyte expression of FGF23 and SOX9, in addition to iron-induced chondrocyte apoptosis and cartilage extracellula...

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Veröffentlicht in:	Hematology (Luxembourg) 2023-12, Vol.28 (1), p.2240585-2240585
Hauptverfasser:	Zheng, Liujie, Yao, Yunfeng, Luo, Dasheng, Han, Zhiwei, Zhang, Xin, Pang, Nanyu, Ding, Mingyang, Ye, Houlong, Zhu, Keyan, Yi, Wenkai
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT Apoptosis Cartilage - metabolism Cartilage - pathology chondrocyte Chondrocytes - metabolism Chondrocytes - pathology FGF23 Forkhead Box Protein O1 - genetics Forkhead Box Protein O1 - metabolism Forkhead Box Protein O1 - pharmacology FOXO1 Haemophilic arthritis Humans iron Iron - metabolism MicroRNAs - genetics Osteoarthritis - metabolism Phosphatidylinositol 3-Kinases - metabolism PI3K Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-akt - pharmacology PTEN PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism SOX9
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