Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency

The taxane class of microtubule stabilizers are some of the most effective and widely used chemotherapeutics. The anticancer activity of taxanes arises from their ability to induce tubulin assembly by selectively recognizing the curved (c-) conformation in unassembled tubulin as compared to the stra...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	European journal of medicinal chemistry 2023-11, Vol.259, p.115668-115668
Hauptverfasser:	Ma, Yuntao, Josa-Prado, Fernando, Essif, Jacob Nathaniel, Liu, Shuqi, Li, Shuo, Lucena-Agell, Daniel, Chan, Peter Yw, Goossens, Kenneth, Hortigüela, Rafael, Matesanz, Ruth, Wang, Yingjie, Gago, Federico, Wang, Hongbo, Risinger, April, Diaz, J Fernando, Fang, Wei-Shuo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!