The small molecule Erk1/2 signaling pathway inhibitor PD98059 improves DNA repair in an experimental autoimmune encephalomyelitis SJL/J mouse model of multiple sclerosis

Multiple sclerosis (MS) is a demyelinating disorder in which the myelin sheath covering the central nervous system axons is damaged or lost, disrupting action potential conduction and leading to various neurological complications. The pathogenesis of MS remains unclear, and no effective therapies ar...

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Veröffentlicht in:	Mutation research. Genetic toxicology and environmental mutagenesis 2023-07, Vol.889, p.503650-503650, Article 503650
Hauptverfasser:	Attia, S.M., Ahmad, S.F., Nadeem, A., Attia, M.S.M., Ansari, M.A., Alsaleh, N.B., Alasmari, A.F., Al-Hamamah, M.A., Alanazi, A., Alshamrani, A.A., Bakheet, S.A., Harisa, G.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA damage Erk1/2 inhibitor PD98059 Modified comet assay Multiple sclerosis pathology Oxidative stress
Online-Zugang:	Volltext
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