Survival in patients undergoing surgical resection for brain metastasis from lung cancer and utility of different prognostic scales
Brain metastases (BM) from lung cancer are among the most common intracranial tumors. Several studies have published scales to estimate the survival of patients with BM. Routine access to molecular diagnostics and modern oncologic treatments, including targeted therapy and immunotherapy, is limited...
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| Veröffentlicht in: | Neurosurgical review 2023-07, Vol.46 (1), p.184-184, Article 184 |
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| creator | Botta, Fábio Pires Rocha, Lilian Aline de Souza, Vanessa das Graças Pereira dos Reis, Patrícia Pintor Lima, Estela de Oliveira Ferrasi, Adriana Camargo Fernandes, Adriano Yacubian Zanini, Marco Antônio Hamamoto Filho, Pedro Tadao |
| description | Brain metastases (BM) from lung cancer are among the most common intracranial tumors. Several studies have published scales to estimate the survival of patients with BM. Routine access to molecular diagnostics and modern oncologic treatments, including targeted therapy and immunotherapy, is limited in low- and middle-income countries (LMICs); therefore, incorporating them into recent prognostic scales may diminish the reliability of the scales in LMICs. This retrospective study aimed to determine the survival of 55 patients who were surgically treated for BM from lung cancer at a Brazilian public tertiary teaching hospital between 2012 and 2022. We determined clinical factors associated with survival, and compared observed survival rates with the estimated survival on prognostic scales. The mean overall survival (OS) was 9.3 months (range:0.2–76.5). At univariate analysis, female sex and improved postoperative Karnofsky performance status (KPS) score were associated with longer survival. The median survival did not differ between groups when classified using the Graded Prognostic Assessment (GPA)-2008, Lung-molecular GPA-2017, and Lung-GPA-2021 scales. According to the Diagnosis-Specific (DS)-GPA-2012 scale, there was a significant difference between the groups. In the multivariate Cox regression survival analysis, a higher DS-GPA-2012 and improved postoperative KPS score remained significantly associated with longer survival. In conclusion, this cohort showed a mean OS of |
| doi_str_mv | 10.1007/s10143-023-02092-3 |
| format | Article |
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Several studies have published scales to estimate the survival of patients with BM. Routine access to molecular diagnostics and modern oncologic treatments, including targeted therapy and immunotherapy, is limited in low- and middle-income countries (LMICs); therefore, incorporating them into recent prognostic scales may diminish the reliability of the scales in LMICs. This retrospective study aimed to determine the survival of 55 patients who were surgically treated for BM from lung cancer at a Brazilian public tertiary teaching hospital between 2012 and 2022. We determined clinical factors associated with survival, and compared observed survival rates with the estimated survival on prognostic scales. The mean overall survival (OS) was 9.3 months (range:0.2–76.5). At univariate analysis, female sex and improved postoperative Karnofsky performance status (KPS) score were associated with longer survival. The median survival did not differ between groups when classified using the Graded Prognostic Assessment (GPA)-2008, Lung-molecular GPA-2017, and Lung-GPA-2021 scales. According to the Diagnosis-Specific (DS)-GPA-2012 scale, there was a significant difference between the groups. In the multivariate Cox regression survival analysis, a higher DS-GPA-2012 and improved postoperative KPS score remained significantly associated with longer survival. In conclusion, this cohort showed a mean OS of < 1 year. Improved KPS score after surgery was associated with increased survival. This cohort DS-GPA scale demonstrated the highest concordance with observed survival, indicating its potential as a valuable tool for patient stratification in surgical treatment decision-making in LMICs.</description><identifier>ISSN: 1437-2320</identifier><identifier>EISSN: 1437-2320</identifier><identifier>DOI: 10.1007/s10143-023-02092-3</identifier><identifier>PMID: 37493965</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Brain Neoplasms - diagnosis ; Brain Neoplasms - pathology ; Brain Neoplasms - surgery ; Female ; Humans ; Lung Neoplasms - diagnosis ; Lung Neoplasms - surgery ; Medicine ; Medicine & Public Health ; Neurosurgery ; Prognosis ; Reproducibility of Results ; Retrospective Studies</subject><ispartof>Neurosurgical review, 2023-07, Vol.46 (1), p.184-184, Article 184</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. 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The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c298t-f05a84a167030bfddb90ff4fb4abf9c45bba38efa3baea91cb9f81ca1450c1f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10143-023-02092-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10143-023-02092-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37493965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Botta, Fábio Pires</creatorcontrib><creatorcontrib>Rocha, Lilian Aline</creatorcontrib><creatorcontrib>de Souza, Vanessa das Graças Pereira</creatorcontrib><creatorcontrib>dos Reis, Patrícia Pintor</creatorcontrib><creatorcontrib>Lima, Estela de Oliveira</creatorcontrib><creatorcontrib>Ferrasi, Adriana Camargo</creatorcontrib><creatorcontrib>Fernandes, Adriano Yacubian</creatorcontrib><creatorcontrib>Zanini, Marco Antônio</creatorcontrib><creatorcontrib>Hamamoto Filho, Pedro Tadao</creatorcontrib><title>Survival in patients undergoing surgical resection for brain metastasis from lung cancer and utility of different prognostic scales</title><title>Neurosurgical review</title><addtitle>Neurosurg Rev</addtitle><addtitle>Neurosurg Rev</addtitle><description>Brain metastases (BM) from lung cancer are among the most common intracranial tumors. Several studies have published scales to estimate the survival of patients with BM. Routine access to molecular diagnostics and modern oncologic treatments, including targeted therapy and immunotherapy, is limited in low- and middle-income countries (LMICs); therefore, incorporating them into recent prognostic scales may diminish the reliability of the scales in LMICs. This retrospective study aimed to determine the survival of 55 patients who were surgically treated for BM from lung cancer at a Brazilian public tertiary teaching hospital between 2012 and 2022. We determined clinical factors associated with survival, and compared observed survival rates with the estimated survival on prognostic scales. The mean overall survival (OS) was 9.3 months (range:0.2–76.5). At univariate analysis, female sex and improved postoperative Karnofsky performance status (KPS) score were associated with longer survival. The median survival did not differ between groups when classified using the Graded Prognostic Assessment (GPA)-2008, Lung-molecular GPA-2017, and Lung-GPA-2021 scales. According to the Diagnosis-Specific (DS)-GPA-2012 scale, there was a significant difference between the groups. In the multivariate Cox regression survival analysis, a higher DS-GPA-2012 and improved postoperative KPS score remained significantly associated with longer survival. In conclusion, this cohort showed a mean OS of < 1 year. Improved KPS score after surgery was associated with increased survival. This cohort DS-GPA scale demonstrated the highest concordance with observed survival, indicating its potential as a valuable tool for patient stratification in surgical treatment decision-making in LMICs.</description><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Prognosis</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><issn>1437-2320</issn><issn>1437-2320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rFjEUhYMotlb_gAvJ0s3UfE1nspTiR6HgQl2HJHMzpMwkr7lJoWv_uHl9q7gSbriX3HMekkPIa84uOWPTO-SMKzkwcTxMi0E-Ief9ZhqEFOzpP_MZeYF4xxifNOPPyZmclJb6ajwnP7-2ch_v7UZjogdbI6SKtKUFyppjWim2skbf9wUQfI050ZALdcV2ww7VYq-INJS80611h7fJQ6E2LbTVuMX6QHOgSwwBSqfTQ8lrylijp9jBgC_Js2A3hFeP_YJ8__jh2_Xn4fbLp5vr97eDF3quQ2CjnZXlVxOTzIVlcZqFoIJT1gXt1eiclTMEK50Fq7l3OszcW65G5nkY5QV5e-L2F_xogNXsET1sm02QGxoxK6FGISbZpeIk9SUjFgjmUOJuy4PhzBzDN6fwTQ_f_A7fHE1vHvnN7bD8tfxJuwvkSYB9lVYo5i63kvqf_4f9BQW7lDI</recordid><startdate>20230726</startdate><enddate>20230726</enddate><creator>Botta, Fábio Pires</creator><creator>Rocha, Lilian Aline</creator><creator>de Souza, Vanessa das Graças Pereira</creator><creator>dos Reis, Patrícia Pintor</creator><creator>Lima, Estela de Oliveira</creator><creator>Ferrasi, Adriana Camargo</creator><creator>Fernandes, Adriano Yacubian</creator><creator>Zanini, Marco Antônio</creator><creator>Hamamoto Filho, Pedro Tadao</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230726</creationdate><title>Survival in patients undergoing surgical resection for brain metastasis from lung cancer and utility of different prognostic scales</title><author>Botta, Fábio Pires ; Rocha, Lilian Aline ; de Souza, Vanessa das Graças Pereira ; dos Reis, Patrícia Pintor ; Lima, Estela de Oliveira ; Ferrasi, Adriana Camargo ; Fernandes, Adriano Yacubian ; Zanini, Marco Antônio ; Hamamoto Filho, Pedro Tadao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-f05a84a167030bfddb90ff4fb4abf9c45bba38efa3baea91cb9f81ca1450c1f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Prognosis</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Botta, Fábio Pires</creatorcontrib><creatorcontrib>Rocha, Lilian Aline</creatorcontrib><creatorcontrib>de Souza, Vanessa das Graças Pereira</creatorcontrib><creatorcontrib>dos Reis, Patrícia Pintor</creatorcontrib><creatorcontrib>Lima, Estela de Oliveira</creatorcontrib><creatorcontrib>Ferrasi, Adriana Camargo</creatorcontrib><creatorcontrib>Fernandes, Adriano Yacubian</creatorcontrib><creatorcontrib>Zanini, Marco Antônio</creatorcontrib><creatorcontrib>Hamamoto Filho, Pedro Tadao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurosurgical review</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Botta, Fábio Pires</au><au>Rocha, Lilian Aline</au><au>de Souza, Vanessa das Graças Pereira</au><au>dos Reis, Patrícia Pintor</au><au>Lima, Estela de Oliveira</au><au>Ferrasi, Adriana Camargo</au><au>Fernandes, Adriano Yacubian</au><au>Zanini, Marco Antônio</au><au>Hamamoto Filho, Pedro Tadao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival in patients undergoing surgical resection for brain metastasis from lung cancer and utility of different prognostic scales</atitle><jtitle>Neurosurgical review</jtitle><stitle>Neurosurg Rev</stitle><addtitle>Neurosurg Rev</addtitle><date>2023-07-26</date><risdate>2023</risdate><volume>46</volume><issue>1</issue><spage>184</spage><epage>184</epage><pages>184-184</pages><artnum>184</artnum><issn>1437-2320</issn><eissn>1437-2320</eissn><abstract>Brain metastases (BM) from lung cancer are among the most common intracranial tumors. 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| subjects | Brain Neoplasms - diagnosis Brain Neoplasms - pathology Brain Neoplasms - surgery Female Humans Lung Neoplasms - diagnosis Lung Neoplasms - surgery Medicine Medicine & Public Health Neurosurgery Prognosis Reproducibility of Results Retrospective Studies |
| title | Survival in patients undergoing surgical resection for brain metastasis from lung cancer and utility of different prognostic scales |
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