MRI-based Vertebral Bone Quality Score for Osteoporosis Screening Based on Different Osteoporotic Diagnostic Criteria Using DXA and QCT
In this study, we aim to evaluate the correlation between T score measured by dual X-ray absorptiometry (DXA), volumetric bone mineral density (vBMD) derived from quantitative computed tomography (QCT) and MRI-based vertebral bone quality (VBQ), explore the diagnostic performance of VBQ in osteoporo...
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description | In this study, we aim to evaluate the correlation between T score measured by dual X-ray absorptiometry (DXA), volumetric bone mineral density (vBMD) derived from quantitative computed tomography (QCT) and MRI-based vertebral bone quality (VBQ), explore the diagnostic performance of VBQ in osteoporosis and determine the recognition value of VBQ in osteoporotic fracture in a relatively large cohort of elderly patients scheduled to undergo spinal surgery. A total of 260 patients were enrolled in the study. DXA and QCT were used to evaluate osteoporotic status. We calculated the lumbar VBQ score, analyzed the correlation between T score, vBMD and VBQ, and explored whether VBQ was an influential factor of bone quality and fracture by binary logistic regression as well as the diagnostic performance of VBQ in osteoporosis and fracture by ROC curve. VBQ was negatively correlated with vBMD and T score. (
r
= − 0.487 vs.
r
= − 0.220). The VBQ score was a risk factor for osteoporosis under the QCT diagnostic criteria (OR = 2.245, 95% CI 1.456–3.460) and osteoporotic fractures (OR = 1.496, 95% CI 1.097–2.040). It exhibited superior discriminant performance for osteoporosis diagnosed by QCT, with a cutoff value of 3.70 and an AUC of 0.7354. Its cutoff value for osteoporotic fractures was 3.72, and its AUC was 0.6717. In a cohort of elderly patients scheduled to undergo spinal surgery, the VBQ score was more strongly associated with vBMD than the T score and could identify patients with osteoporosis and corresponding vertebral compression fracture (VCF). |
doi_str_mv | 10.1007/s00223-023-01115-x |
format | Article |
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r
= − 0.487 vs.
r
= − 0.220). The VBQ score was a risk factor for osteoporosis under the QCT diagnostic criteria (OR = 2.245, 95% CI 1.456–3.460) and osteoporotic fractures (OR = 1.496, 95% CI 1.097–2.040). It exhibited superior discriminant performance for osteoporosis diagnosed by QCT, with a cutoff value of 3.70 and an AUC of 0.7354. Its cutoff value for osteoporotic fractures was 3.72, and its AUC was 0.6717. In a cohort of elderly patients scheduled to undergo spinal surgery, the VBQ score was more strongly associated with vBMD than the T score and could identify patients with osteoporosis and corresponding vertebral compression fracture (VCF).</description><identifier>ISSN: 1432-0827</identifier><identifier>ISSN: 0171-967X</identifier><identifier>EISSN: 1432-0827</identifier><identifier>DOI: 10.1007/s00223-023-01115-x</identifier><identifier>PMID: 37493798</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Absorptiometry ; Back surgery ; Biochemistry ; Biomedical and Life Sciences ; Bone mineral density ; Cell Biology ; Computed tomography ; Dual energy X-ray absorptiometry ; Endocrinology ; Fractures ; Life Sciences ; Magnetic resonance imaging ; Medical diagnosis ; Original Research ; Orthopedics ; Osteoporosis ; Risk factors ; Surgery ; Vertebrae</subject><ispartof>Calcified tissue international, 2023-10, Vol.113 (4), p.383-392</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4487c0d2b4af24d23745ea3e754a923846e2b08c3726157323d1ca0032647a9a3</citedby><cites>FETCH-LOGICAL-c375t-4487c0d2b4af24d23745ea3e754a923846e2b08c3726157323d1ca0032647a9a3</cites><orcidid>0000-0001-6951-1261</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00223-023-01115-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00223-023-01115-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37493798$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, Houjie</creatorcontrib><creatorcontrib>Lin, Wentao</creatorcontrib><creatorcontrib>Xie, Faqin</creatorcontrib><creatorcontrib>He, Chaoqin</creatorcontrib><creatorcontrib>Chen, Tao</creatorcontrib><creatorcontrib>Zheng, Guanghao</creatorcontrib><creatorcontrib>Wang, Zhiyun</creatorcontrib><title>MRI-based Vertebral Bone Quality Score for Osteoporosis Screening Based on Different Osteoporotic Diagnostic Criteria Using DXA and QCT</title><title>Calcified tissue international</title><addtitle>Calcif Tissue Int</addtitle><addtitle>Calcif Tissue Int</addtitle><description>In this study, we aim to evaluate the correlation between T score measured by dual X-ray absorptiometry (DXA), volumetric bone mineral density (vBMD) derived from quantitative computed tomography (QCT) and MRI-based vertebral bone quality (VBQ), explore the diagnostic performance of VBQ in osteoporosis and determine the recognition value of VBQ in osteoporotic fracture in a relatively large cohort of elderly patients scheduled to undergo spinal surgery. A total of 260 patients were enrolled in the study. DXA and QCT were used to evaluate osteoporotic status. We calculated the lumbar VBQ score, analyzed the correlation between T score, vBMD and VBQ, and explored whether VBQ was an influential factor of bone quality and fracture by binary logistic regression as well as the diagnostic performance of VBQ in osteoporosis and fracture by ROC curve. VBQ was negatively correlated with vBMD and T score. (
r
= − 0.487 vs.
r
= − 0.220). The VBQ score was a risk factor for osteoporosis under the QCT diagnostic criteria (OR = 2.245, 95% CI 1.456–3.460) and osteoporotic fractures (OR = 1.496, 95% CI 1.097–2.040). It exhibited superior discriminant performance for osteoporosis diagnosed by QCT, with a cutoff value of 3.70 and an AUC of 0.7354. Its cutoff value for osteoporotic fractures was 3.72, and its AUC was 0.6717. In a cohort of elderly patients scheduled to undergo spinal surgery, the VBQ score was more strongly associated with vBMD than the T score and could identify patients with osteoporosis and corresponding vertebral compression fracture (VCF).</description><subject>Absorptiometry</subject><subject>Back surgery</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Bone mineral density</subject><subject>Cell Biology</subject><subject>Computed tomography</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Endocrinology</subject><subject>Fractures</subject><subject>Life Sciences</subject><subject>Magnetic resonance imaging</subject><subject>Medical diagnosis</subject><subject>Original Research</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Risk factors</subject><subject>Surgery</subject><subject>Vertebrae</subject><issn>1432-0827</issn><issn>0171-967X</issn><issn>1432-0827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1O3TAQha2Kqvy0L8ACWWLDJu147MTJEi60RaJCUKi6i5xkcmWUa1_sRIIn6Gvj9NJSdcFi5NH4O8c_h7F9AR8FgP4UARBlBnMJIfLs4Q3bEUpiBiXqrX_6bbYb4x2AUEVRvGPbUqtK6qrcYb--XZ9njYnU8R8URmqCGfiJd8SvJjPY8ZF_b30g3vvAL-NIfu2DjzamcSBy1i35yW-1d_zU9j0FcuMLOdo2jc3S-Ti3i2BHCtbw2zgrT38ec-M6frW4ec_e9maI9OF53WO3n89uFl-zi8sv54vji6yVOh8zpUrdQoeNMj2qDtNDcjKSdK5MhbJUBWEDZYKxELmWKDvRGgCJhdKmMnKPHW1818HfTxTHemVjS8NgHPkp1lgqVDlCVSX08D_0zk_BpdslqtBKoACdKNxQbfqXGKiv18GuTHisBdRzTPUmphrmmmOqH5Lo4Nl6albU_ZX8ySUBcgPEtOWWFF7OfsX2CQBcnLA</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Yin, Houjie</creator><creator>Lin, Wentao</creator><creator>Xie, Faqin</creator><creator>He, Chaoqin</creator><creator>Chen, Tao</creator><creator>Zheng, Guanghao</creator><creator>Wang, Zhiyun</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6951-1261</orcidid></search><sort><creationdate>20231001</creationdate><title>MRI-based Vertebral Bone Quality Score for Osteoporosis Screening Based on Different Osteoporotic Diagnostic Criteria Using DXA and QCT</title><author>Yin, Houjie ; Lin, Wentao ; Xie, Faqin ; He, Chaoqin ; Chen, Tao ; Zheng, Guanghao ; Wang, Zhiyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-4487c0d2b4af24d23745ea3e754a923846e2b08c3726157323d1ca0032647a9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Absorptiometry</topic><topic>Back surgery</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Bone mineral density</topic><topic>Cell Biology</topic><topic>Computed tomography</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Endocrinology</topic><topic>Fractures</topic><topic>Life Sciences</topic><topic>Magnetic resonance imaging</topic><topic>Medical diagnosis</topic><topic>Original Research</topic><topic>Orthopedics</topic><topic>Osteoporosis</topic><topic>Risk factors</topic><topic>Surgery</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Houjie</creatorcontrib><creatorcontrib>Lin, Wentao</creatorcontrib><creatorcontrib>Xie, Faqin</creatorcontrib><creatorcontrib>He, Chaoqin</creatorcontrib><creatorcontrib>Chen, Tao</creatorcontrib><creatorcontrib>Zheng, Guanghao</creatorcontrib><creatorcontrib>Wang, Zhiyun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Calcified tissue international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Houjie</au><au>Lin, Wentao</au><au>Xie, Faqin</au><au>He, Chaoqin</au><au>Chen, Tao</au><au>Zheng, Guanghao</au><au>Wang, Zhiyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MRI-based Vertebral Bone Quality Score for Osteoporosis Screening Based on Different Osteoporotic Diagnostic Criteria Using DXA and QCT</atitle><jtitle>Calcified tissue international</jtitle><stitle>Calcif Tissue Int</stitle><addtitle>Calcif Tissue Int</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>113</volume><issue>4</issue><spage>383</spage><epage>392</epage><pages>383-392</pages><issn>1432-0827</issn><issn>0171-967X</issn><eissn>1432-0827</eissn><abstract>In this study, we aim to evaluate the correlation between T score measured by dual X-ray absorptiometry (DXA), volumetric bone mineral density (vBMD) derived from quantitative computed tomography (QCT) and MRI-based vertebral bone quality (VBQ), explore the diagnostic performance of VBQ in osteoporosis and determine the recognition value of VBQ in osteoporotic fracture in a relatively large cohort of elderly patients scheduled to undergo spinal surgery. A total of 260 patients were enrolled in the study. DXA and QCT were used to evaluate osteoporotic status. We calculated the lumbar VBQ score, analyzed the correlation between T score, vBMD and VBQ, and explored whether VBQ was an influential factor of bone quality and fracture by binary logistic regression as well as the diagnostic performance of VBQ in osteoporosis and fracture by ROC curve. VBQ was negatively correlated with vBMD and T score. (
r
= − 0.487 vs.
r
= − 0.220). The VBQ score was a risk factor for osteoporosis under the QCT diagnostic criteria (OR = 2.245, 95% CI 1.456–3.460) and osteoporotic fractures (OR = 1.496, 95% CI 1.097–2.040). It exhibited superior discriminant performance for osteoporosis diagnosed by QCT, with a cutoff value of 3.70 and an AUC of 0.7354. Its cutoff value for osteoporotic fractures was 3.72, and its AUC was 0.6717. In a cohort of elderly patients scheduled to undergo spinal surgery, the VBQ score was more strongly associated with vBMD than the T score and could identify patients with osteoporosis and corresponding vertebral compression fracture (VCF).</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37493798</pmid><doi>10.1007/s00223-023-01115-x</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6951-1261</orcidid></addata></record> |
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subjects | Absorptiometry Back surgery Biochemistry Biomedical and Life Sciences Bone mineral density Cell Biology Computed tomography Dual energy X-ray absorptiometry Endocrinology Fractures Life Sciences Magnetic resonance imaging Medical diagnosis Original Research Orthopedics Osteoporosis Risk factors Surgery Vertebrae |
title | MRI-based Vertebral Bone Quality Score for Osteoporosis Screening Based on Different Osteoporotic Diagnostic Criteria Using DXA and QCT |
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