MRI-based Vertebral Bone Quality Score for Osteoporosis Screening Based on Different Osteoporotic Diagnostic Criteria Using DXA and QCT

In this study, we aim to evaluate the correlation between T score measured by dual X-ray absorptiometry (DXA), volumetric bone mineral density (vBMD) derived from quantitative computed tomography (QCT) and MRI-based vertebral bone quality (VBQ), explore the diagnostic performance of VBQ in osteoporo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Calcified tissue international 2023-10, Vol.113 (4), p.383-392
Hauptverfasser: Yin, Houjie, Lin, Wentao, Xie, Faqin, He, Chaoqin, Chen, Tao, Zheng, Guanghao, Wang, Zhiyun
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 392
container_issue 4
container_start_page 383
container_title Calcified tissue international
container_volume 113
creator Yin, Houjie
Lin, Wentao
Xie, Faqin
He, Chaoqin
Chen, Tao
Zheng, Guanghao
Wang, Zhiyun
description In this study, we aim to evaluate the correlation between T score measured by dual X-ray absorptiometry (DXA), volumetric bone mineral density (vBMD) derived from quantitative computed tomography (QCT) and MRI-based vertebral bone quality (VBQ), explore the diagnostic performance of VBQ in osteoporosis and determine the recognition value of VBQ in osteoporotic fracture in a relatively large cohort of elderly patients scheduled to undergo spinal surgery. A total of 260 patients were enrolled in the study. DXA and QCT were used to evaluate osteoporotic status. We calculated the lumbar VBQ score, analyzed the correlation between T score, vBMD and VBQ, and explored whether VBQ was an influential factor of bone quality and fracture by binary logistic regression as well as the diagnostic performance of VBQ in osteoporosis and fracture by ROC curve. VBQ was negatively correlated with vBMD and T score. ( r  = − 0.487 vs. r  = − 0.220). The VBQ score was a risk factor for osteoporosis under the QCT diagnostic criteria (OR = 2.245, 95% CI 1.456–3.460) and osteoporotic fractures (OR = 1.496, 95% CI 1.097–2.040). It exhibited superior discriminant performance for osteoporosis diagnosed by QCT, with a cutoff value of 3.70 and an AUC of 0.7354. Its cutoff value for osteoporotic fractures was 3.72, and its AUC was 0.6717. In a cohort of elderly patients scheduled to undergo spinal surgery, the VBQ score was more strongly associated with vBMD than the T score and could identify patients with osteoporosis and corresponding vertebral compression fracture (VCF).
doi_str_mv 10.1007/s00223-023-01115-x
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2842452099</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2867412107</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-4487c0d2b4af24d23745ea3e754a923846e2b08c3726157323d1ca0032647a9a3</originalsourceid><addsrcrecordid>eNp9kc1O3TAQha2Kqvy0L8ACWWLDJu147MTJEi60RaJCUKi6i5xkcmWUa1_sRIIn6Gvj9NJSdcFi5NH4O8c_h7F9AR8FgP4UARBlBnMJIfLs4Q3bEUpiBiXqrX_6bbYb4x2AUEVRvGPbUqtK6qrcYb--XZ9njYnU8R8URmqCGfiJd8SvJjPY8ZF_b30g3vvAL-NIfu2DjzamcSBy1i35yW-1d_zU9j0FcuMLOdo2jc3S-Ti3i2BHCtbw2zgrT38ec-M6frW4ec_e9maI9OF53WO3n89uFl-zi8sv54vji6yVOh8zpUrdQoeNMj2qDtNDcjKSdK5MhbJUBWEDZYKxELmWKDvRGgCJhdKmMnKPHW1818HfTxTHemVjS8NgHPkp1lgqVDlCVSX08D_0zk_BpdslqtBKoACdKNxQbfqXGKiv18GuTHisBdRzTPUmphrmmmOqH5Lo4Nl6albU_ZX8ySUBcgPEtOWWFF7OfsX2CQBcnLA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2867412107</pqid></control><display><type>article</type><title>MRI-based Vertebral Bone Quality Score for Osteoporosis Screening Based on Different Osteoporotic Diagnostic Criteria Using DXA and QCT</title><source>SpringerLink Journals</source><creator>Yin, Houjie ; Lin, Wentao ; Xie, Faqin ; He, Chaoqin ; Chen, Tao ; Zheng, Guanghao ; Wang, Zhiyun</creator><creatorcontrib>Yin, Houjie ; Lin, Wentao ; Xie, Faqin ; He, Chaoqin ; Chen, Tao ; Zheng, Guanghao ; Wang, Zhiyun</creatorcontrib><description>In this study, we aim to evaluate the correlation between T score measured by dual X-ray absorptiometry (DXA), volumetric bone mineral density (vBMD) derived from quantitative computed tomography (QCT) and MRI-based vertebral bone quality (VBQ), explore the diagnostic performance of VBQ in osteoporosis and determine the recognition value of VBQ in osteoporotic fracture in a relatively large cohort of elderly patients scheduled to undergo spinal surgery. A total of 260 patients were enrolled in the study. DXA and QCT were used to evaluate osteoporotic status. We calculated the lumbar VBQ score, analyzed the correlation between T score, vBMD and VBQ, and explored whether VBQ was an influential factor of bone quality and fracture by binary logistic regression as well as the diagnostic performance of VBQ in osteoporosis and fracture by ROC curve. VBQ was negatively correlated with vBMD and T score. ( r  = − 0.487 vs. r  = − 0.220). The VBQ score was a risk factor for osteoporosis under the QCT diagnostic criteria (OR = 2.245, 95% CI 1.456–3.460) and osteoporotic fractures (OR = 1.496, 95% CI 1.097–2.040). It exhibited superior discriminant performance for osteoporosis diagnosed by QCT, with a cutoff value of 3.70 and an AUC of 0.7354. Its cutoff value for osteoporotic fractures was 3.72, and its AUC was 0.6717. In a cohort of elderly patients scheduled to undergo spinal surgery, the VBQ score was more strongly associated with vBMD than the T score and could identify patients with osteoporosis and corresponding vertebral compression fracture (VCF).</description><identifier>ISSN: 1432-0827</identifier><identifier>ISSN: 0171-967X</identifier><identifier>EISSN: 1432-0827</identifier><identifier>DOI: 10.1007/s00223-023-01115-x</identifier><identifier>PMID: 37493798</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Absorptiometry ; Back surgery ; Biochemistry ; Biomedical and Life Sciences ; Bone mineral density ; Cell Biology ; Computed tomography ; Dual energy X-ray absorptiometry ; Endocrinology ; Fractures ; Life Sciences ; Magnetic resonance imaging ; Medical diagnosis ; Original Research ; Orthopedics ; Osteoporosis ; Risk factors ; Surgery ; Vertebrae</subject><ispartof>Calcified tissue international, 2023-10, Vol.113 (4), p.383-392</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-4487c0d2b4af24d23745ea3e754a923846e2b08c3726157323d1ca0032647a9a3</citedby><cites>FETCH-LOGICAL-c375t-4487c0d2b4af24d23745ea3e754a923846e2b08c3726157323d1ca0032647a9a3</cites><orcidid>0000-0001-6951-1261</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00223-023-01115-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00223-023-01115-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37493798$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, Houjie</creatorcontrib><creatorcontrib>Lin, Wentao</creatorcontrib><creatorcontrib>Xie, Faqin</creatorcontrib><creatorcontrib>He, Chaoqin</creatorcontrib><creatorcontrib>Chen, Tao</creatorcontrib><creatorcontrib>Zheng, Guanghao</creatorcontrib><creatorcontrib>Wang, Zhiyun</creatorcontrib><title>MRI-based Vertebral Bone Quality Score for Osteoporosis Screening Based on Different Osteoporotic Diagnostic Criteria Using DXA and QCT</title><title>Calcified tissue international</title><addtitle>Calcif Tissue Int</addtitle><addtitle>Calcif Tissue Int</addtitle><description>In this study, we aim to evaluate the correlation between T score measured by dual X-ray absorptiometry (DXA), volumetric bone mineral density (vBMD) derived from quantitative computed tomography (QCT) and MRI-based vertebral bone quality (VBQ), explore the diagnostic performance of VBQ in osteoporosis and determine the recognition value of VBQ in osteoporotic fracture in a relatively large cohort of elderly patients scheduled to undergo spinal surgery. A total of 260 patients were enrolled in the study. DXA and QCT were used to evaluate osteoporotic status. We calculated the lumbar VBQ score, analyzed the correlation between T score, vBMD and VBQ, and explored whether VBQ was an influential factor of bone quality and fracture by binary logistic regression as well as the diagnostic performance of VBQ in osteoporosis and fracture by ROC curve. VBQ was negatively correlated with vBMD and T score. ( r  = − 0.487 vs. r  = − 0.220). The VBQ score was a risk factor for osteoporosis under the QCT diagnostic criteria (OR = 2.245, 95% CI 1.456–3.460) and osteoporotic fractures (OR = 1.496, 95% CI 1.097–2.040). It exhibited superior discriminant performance for osteoporosis diagnosed by QCT, with a cutoff value of 3.70 and an AUC of 0.7354. Its cutoff value for osteoporotic fractures was 3.72, and its AUC was 0.6717. In a cohort of elderly patients scheduled to undergo spinal surgery, the VBQ score was more strongly associated with vBMD than the T score and could identify patients with osteoporosis and corresponding vertebral compression fracture (VCF).</description><subject>Absorptiometry</subject><subject>Back surgery</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Bone mineral density</subject><subject>Cell Biology</subject><subject>Computed tomography</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Endocrinology</subject><subject>Fractures</subject><subject>Life Sciences</subject><subject>Magnetic resonance imaging</subject><subject>Medical diagnosis</subject><subject>Original Research</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Risk factors</subject><subject>Surgery</subject><subject>Vertebrae</subject><issn>1432-0827</issn><issn>0171-967X</issn><issn>1432-0827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1O3TAQha2Kqvy0L8ACWWLDJu147MTJEi60RaJCUKi6i5xkcmWUa1_sRIIn6Gvj9NJSdcFi5NH4O8c_h7F9AR8FgP4UARBlBnMJIfLs4Q3bEUpiBiXqrX_6bbYb4x2AUEVRvGPbUqtK6qrcYb--XZ9njYnU8R8URmqCGfiJd8SvJjPY8ZF_b30g3vvAL-NIfu2DjzamcSBy1i35yW-1d_zU9j0FcuMLOdo2jc3S-Ti3i2BHCtbw2zgrT38ec-M6frW4ec_e9maI9OF53WO3n89uFl-zi8sv54vji6yVOh8zpUrdQoeNMj2qDtNDcjKSdK5MhbJUBWEDZYKxELmWKDvRGgCJhdKmMnKPHW1818HfTxTHemVjS8NgHPkp1lgqVDlCVSX08D_0zk_BpdslqtBKoACdKNxQbfqXGKiv18GuTHisBdRzTPUmphrmmmOqH5Lo4Nl6albU_ZX8ySUBcgPEtOWWFF7OfsX2CQBcnLA</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Yin, Houjie</creator><creator>Lin, Wentao</creator><creator>Xie, Faqin</creator><creator>He, Chaoqin</creator><creator>Chen, Tao</creator><creator>Zheng, Guanghao</creator><creator>Wang, Zhiyun</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6951-1261</orcidid></search><sort><creationdate>20231001</creationdate><title>MRI-based Vertebral Bone Quality Score for Osteoporosis Screening Based on Different Osteoporotic Diagnostic Criteria Using DXA and QCT</title><author>Yin, Houjie ; Lin, Wentao ; Xie, Faqin ; He, Chaoqin ; Chen, Tao ; Zheng, Guanghao ; Wang, Zhiyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-4487c0d2b4af24d23745ea3e754a923846e2b08c3726157323d1ca0032647a9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Absorptiometry</topic><topic>Back surgery</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Bone mineral density</topic><topic>Cell Biology</topic><topic>Computed tomography</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Endocrinology</topic><topic>Fractures</topic><topic>Life Sciences</topic><topic>Magnetic resonance imaging</topic><topic>Medical diagnosis</topic><topic>Original Research</topic><topic>Orthopedics</topic><topic>Osteoporosis</topic><topic>Risk factors</topic><topic>Surgery</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Houjie</creatorcontrib><creatorcontrib>Lin, Wentao</creatorcontrib><creatorcontrib>Xie, Faqin</creatorcontrib><creatorcontrib>He, Chaoqin</creatorcontrib><creatorcontrib>Chen, Tao</creatorcontrib><creatorcontrib>Zheng, Guanghao</creatorcontrib><creatorcontrib>Wang, Zhiyun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Calcified tissue international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Houjie</au><au>Lin, Wentao</au><au>Xie, Faqin</au><au>He, Chaoqin</au><au>Chen, Tao</au><au>Zheng, Guanghao</au><au>Wang, Zhiyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MRI-based Vertebral Bone Quality Score for Osteoporosis Screening Based on Different Osteoporotic Diagnostic Criteria Using DXA and QCT</atitle><jtitle>Calcified tissue international</jtitle><stitle>Calcif Tissue Int</stitle><addtitle>Calcif Tissue Int</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>113</volume><issue>4</issue><spage>383</spage><epage>392</epage><pages>383-392</pages><issn>1432-0827</issn><issn>0171-967X</issn><eissn>1432-0827</eissn><abstract>In this study, we aim to evaluate the correlation between T score measured by dual X-ray absorptiometry (DXA), volumetric bone mineral density (vBMD) derived from quantitative computed tomography (QCT) and MRI-based vertebral bone quality (VBQ), explore the diagnostic performance of VBQ in osteoporosis and determine the recognition value of VBQ in osteoporotic fracture in a relatively large cohort of elderly patients scheduled to undergo spinal surgery. A total of 260 patients were enrolled in the study. DXA and QCT were used to evaluate osteoporotic status. We calculated the lumbar VBQ score, analyzed the correlation between T score, vBMD and VBQ, and explored whether VBQ was an influential factor of bone quality and fracture by binary logistic regression as well as the diagnostic performance of VBQ in osteoporosis and fracture by ROC curve. VBQ was negatively correlated with vBMD and T score. ( r  = − 0.487 vs. r  = − 0.220). The VBQ score was a risk factor for osteoporosis under the QCT diagnostic criteria (OR = 2.245, 95% CI 1.456–3.460) and osteoporotic fractures (OR = 1.496, 95% CI 1.097–2.040). It exhibited superior discriminant performance for osteoporosis diagnosed by QCT, with a cutoff value of 3.70 and an AUC of 0.7354. Its cutoff value for osteoporotic fractures was 3.72, and its AUC was 0.6717. In a cohort of elderly patients scheduled to undergo spinal surgery, the VBQ score was more strongly associated with vBMD than the T score and could identify patients with osteoporosis and corresponding vertebral compression fracture (VCF).</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37493798</pmid><doi>10.1007/s00223-023-01115-x</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6951-1261</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 1432-0827
ispartof Calcified tissue international, 2023-10, Vol.113 (4), p.383-392
issn 1432-0827
0171-967X
1432-0827
language eng
recordid cdi_proquest_miscellaneous_2842452099
source SpringerLink Journals
subjects Absorptiometry
Back surgery
Biochemistry
Biomedical and Life Sciences
Bone mineral density
Cell Biology
Computed tomography
Dual energy X-ray absorptiometry
Endocrinology
Fractures
Life Sciences
Magnetic resonance imaging
Medical diagnosis
Original Research
Orthopedics
Osteoporosis
Risk factors
Surgery
Vertebrae
title MRI-based Vertebral Bone Quality Score for Osteoporosis Screening Based on Different Osteoporotic Diagnostic Criteria Using DXA and QCT
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T19%3A37%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MRI-based%20Vertebral%20Bone%20Quality%20Score%20for%20Osteoporosis%20Screening%20Based%20on%20Different%20Osteoporotic%20Diagnostic%20Criteria%20Using%20DXA%20and%20QCT&rft.jtitle=Calcified%20tissue%20international&rft.au=Yin,%20Houjie&rft.date=2023-10-01&rft.volume=113&rft.issue=4&rft.spage=383&rft.epage=392&rft.pages=383-392&rft.issn=1432-0827&rft.eissn=1432-0827&rft_id=info:doi/10.1007/s00223-023-01115-x&rft_dat=%3Cproquest_cross%3E2867412107%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2867412107&rft_id=info:pmid/37493798&rfr_iscdi=true