Biology and therapeutic targeting of vascular endothelial growth factor A

The formation of new blood vessels, called angiogenesis, is an essential pathophysiological process in which several families of regulators have been implicated. Among these, vascular endothelial growth factor A (VEGFA; also known as VEGF) and its two tyrosine kinase receptors, VEGFR1 and VEGFR2, re...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2023-11, Vol.24 (11), p.816-834
Hauptverfasser:	Pérez-Gutiérrez, Lorena, Ferrara, Napoleone
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/16 631/80/304 Age Age related diseases Angiogenesis Angiogenesis Inhibitors - therapeutic use Antiangiogenic agents Antiangiogenics Biochemistry Biology Biomedical and Life Sciences Blood vessels Cancer Research Cell Biology Cellular structure Chemotherapy Cloning Developmental Biology Disorders Drug development Eye Eye diseases Eye disorders Female Growth factors Health services Humans Immunotherapy Ischemia Kinases Life Sciences Macular degeneration Malignancy Neoplasms - drug therapy Neoplasms - genetics Oncology Pathophysiology Placenta Growth Factor Protein-tyrosine kinase Regenerative medicine Review Article Signal transduction Signalling systems Sphingosine 1-phosphate Stem Cells Therapeutic targets Tissue engineering Tyrosine Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascularization
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