Pig-to-human heart xenotransplantation in two recently deceased human recipients

Genetically modified xenografts are one of the most promising solutions to the discrepancy between the numbers of available human organs for transplantation and potential recipients. To date, a porcine heart has been implanted into only one human recipient. Here, using 10-gene-edited pigs, we transp...

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Veröffentlicht in:	Nature medicine 2023-08, Vol.29 (8), p.1989-1997
Hauptverfasser:	Moazami, Nader, Stern, Jeffrey M., Khalil, Karen, Kim, Jacqueline I., Narula, Navneet, Mangiola, Massimo, Weldon, Elaina P., Kagermazova, Larisa, James, Les, Lawson, Nikki, Piper, Greta L., Sommer, Philip M., Reyentovich, Alex, Bamira, Daniel, Saraon, Tajinderpal, Kadosh, Bernard S., DiVita, Michael, Goldberg, Randal I., Hussain, Syed T., Chan, Justin, Ngai, Jennie, Jan, Thomas, Ali, Nicole M., Tatapudi, Vasishta S., Segev, Dorry L., Bisen, Shivani, Jaffe, Ian S., Piegari, Benjamin, Kowalski, Haley, Kokkinaki, Maria, Monahan, Jeffrey, Sorrells, Lori, Burdorf, Lars, Boeke, Jef D., Pass, Harvey, Goparaju, Chandra, Keating, Brendan, Ayares, David, Lorber, Marc, Griesemer, Adam, Mehta, Sapna A., Smith, Deane E., Montgomery, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1854 631/250/24 631/250/2520 692/308/575 706/703/559 Antibodies Biomedical and Life Sciences Biomedicine Cancer Research Cardiac function Clinical trials Cytotoxicity Flow cytometry Genetic modification Graft rejection Heart transplantation Hemodynamics Histocompatibility testing Histology Hogs Infectious Diseases Metabolic Diseases Molecular Medicine Neurosciences Rejection Swine Transgenes Xenografts Xenotransplantation Zoonoses
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