Associations between spirometric measures and exercise capacity in type 2 diabetes
Physical exercise aids glycemic control and the prevention of diabetes-related complications. However, exercise beyond an individual's pulmonary functional capacity may be detrimental. To date, little is known about the relationship between pulmonary function and exercise capacity in people wit...
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| Veröffentlicht in: | Diabetes & metabolic syndrome clinical research & reviews 2023-08, Vol.17 (8), p.102831-102831, Article 102831 |
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| creator | Antwi-Boasiako, Charles Kollie, Mulbah Fasama Kyeremeh, Kumi Ampaabeng Osei-Tutu, Josephine Korang Musah, Latif Vormatu, Patience Tei, Ruth Korkor Hanson, Tracy Sackitey-Ninye, Sylvia Esther Quartey-Papafio, Theresa Ruby Hayfron-Benjamin, Charles F. |
| description | Physical exercise aids glycemic control and the prevention of diabetes-related complications. However, exercise beyond an individual's pulmonary functional capacity may be detrimental. To date, little is known about the relationship between pulmonary function and exercise capacity in people with type 2 diabetes (T2D). We investigated the relationship between pulmonary function and exercise capacity in T2D.
Spirometry and 6-min walk test (6MWT) were conducted for 263 systematically sampled adults with T2D without primary heart/lung disease. The primary measure of exercise capacity was the 6-min walk distance (6MWD); impaired exercise capacity was defined as 6MWD |
| doi_str_mv | 10.1016/j.dsx.2023.102831 |
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Spirometry and 6-min walk test (6MWT) were conducted for 263 systematically sampled adults with T2D without primary heart/lung disease. The primary measure of exercise capacity was the 6-min walk distance (6MWD); impaired exercise capacity was defined as 6MWD<400 m. Logistic regression analyses were used to assess the associations between spirometric measures and exercise capacity with adjustments for age, sex, height, body mass index, diabetes duration, glycated hemoglobin concentration, smoking, suboptimum blood pressure control, and total cholesterol concentration.
Compared with individuals with normal spirometry, those with pulmonary restriction/obstruction had significantly lower 6MWD (404.67 m vs. 451.70),p < 0.001). The proportion of individuals with impaired exercise capacity was higher in individuals with impaired pulmonary function compared with those with normal pulmonary function (39.8% vs. 20.7%,p = 0.001). In the unadjusted models, decreasing Z-score FEV1 [odds ratio 1.40, 95% confidence interval (1.07–1.83),p = 0.013] and Z-score FVC [1.37 (1.06–1.76),0.016], but not Z-score FEV1/FVC ratio [1.00 (0.78–1.27),0.972] were significantly associated with impaired exercise capacity. In the fully adjusted model, the strength of association remained statistically significant for Z-score FEV1 [1.60 (1.06–2.41),0.025] but not Z-score FVC [1.48 (0.98–2.23),0.065].
Our study shows inverse associations between FEV1 and impaired exercise capacity in T2D, Future research could characterize optimal exercise levels based on a patient's FEV1.
•Impaired exercise capacity was commoner in patients with type 2 diabetes with lung dysfunction than without lung dysfunction.•Lower forced expiratory volume in 1 s was positively associated with impaired exercise capacity.•The conventional cardiovascular and respiratory risk factors did not explain the observed associations.</description><identifier>ISSN: 1871-4021</identifier><identifier>EISSN: 1878-0334</identifier><identifier>DOI: 10.1016/j.dsx.2023.102831</identifier><identifier>PMID: 37487361</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Diabetes ; Pulmonary function ; Six-minute walk test ; Spirometry ; Submaximal exercise capacity</subject><ispartof>Diabetes & metabolic syndrome clinical research & reviews, 2023-08, Vol.17 (8), p.102831-102831, Article 102831</ispartof><rights>2023 The Authors</rights><rights>Copyright © 2023. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c348t-17b341afc785c2004474ed1574758e3a93565c094460cd22734a0087aa9924993</cites><orcidid>0000-0003-0175-0340</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1871402123001273$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37487361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Antwi-Boasiako, Charles</creatorcontrib><creatorcontrib>Kollie, Mulbah Fasama</creatorcontrib><creatorcontrib>Kyeremeh, Kumi Ampaabeng</creatorcontrib><creatorcontrib>Osei-Tutu, Josephine Korang</creatorcontrib><creatorcontrib>Musah, Latif</creatorcontrib><creatorcontrib>Vormatu, Patience</creatorcontrib><creatorcontrib>Tei, Ruth Korkor</creatorcontrib><creatorcontrib>Hanson, Tracy</creatorcontrib><creatorcontrib>Sackitey-Ninye, Sylvia Esther</creatorcontrib><creatorcontrib>Quartey-Papafio, Theresa Ruby</creatorcontrib><creatorcontrib>Hayfron-Benjamin, Charles F.</creatorcontrib><title>Associations between spirometric measures and exercise capacity in type 2 diabetes</title><title>Diabetes & metabolic syndrome clinical research & reviews</title><addtitle>Diabetes Metab Syndr</addtitle><description>Physical exercise aids glycemic control and the prevention of diabetes-related complications. However, exercise beyond an individual's pulmonary functional capacity may be detrimental. To date, little is known about the relationship between pulmonary function and exercise capacity in people with type 2 diabetes (T2D). We investigated the relationship between pulmonary function and exercise capacity in T2D.
Spirometry and 6-min walk test (6MWT) were conducted for 263 systematically sampled adults with T2D without primary heart/lung disease. The primary measure of exercise capacity was the 6-min walk distance (6MWD); impaired exercise capacity was defined as 6MWD<400 m. Logistic regression analyses were used to assess the associations between spirometric measures and exercise capacity with adjustments for age, sex, height, body mass index, diabetes duration, glycated hemoglobin concentration, smoking, suboptimum blood pressure control, and total cholesterol concentration.
Compared with individuals with normal spirometry, those with pulmonary restriction/obstruction had significantly lower 6MWD (404.67 m vs. 451.70),p < 0.001). The proportion of individuals with impaired exercise capacity was higher in individuals with impaired pulmonary function compared with those with normal pulmonary function (39.8% vs. 20.7%,p = 0.001). In the unadjusted models, decreasing Z-score FEV1 [odds ratio 1.40, 95% confidence interval (1.07–1.83),p = 0.013] and Z-score FVC [1.37 (1.06–1.76),0.016], but not Z-score FEV1/FVC ratio [1.00 (0.78–1.27),0.972] were significantly associated with impaired exercise capacity. In the fully adjusted model, the strength of association remained statistically significant for Z-score FEV1 [1.60 (1.06–2.41),0.025] but not Z-score FVC [1.48 (0.98–2.23),0.065].
Our study shows inverse associations between FEV1 and impaired exercise capacity in T2D, Future research could characterize optimal exercise levels based on a patient's FEV1.
•Impaired exercise capacity was commoner in patients with type 2 diabetes with lung dysfunction than without lung dysfunction.•Lower forced expiratory volume in 1 s was positively associated with impaired exercise capacity.•The conventional cardiovascular and respiratory risk factors did not explain the observed associations.</description><subject>Diabetes</subject><subject>Pulmonary function</subject><subject>Six-minute walk test</subject><subject>Spirometry</subject><subject>Submaximal exercise capacity</subject><issn>1871-4021</issn><issn>1878-0334</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoVqs_wIvk6GVrvnaT4KkUv6AgiJ5Dmp1CSvfDzFbbf-_WrR49zQw87wvzEHLF2YQzXtyuJiVuJ4IJ2d_CSH5EzrjRJmNSquOfnWeKCT4i54grxvLcCntKRlIro2XBz8jrFLEJ0XexqZEuoPsCqCm2MTUVdCkGWoHHTQKkvi4pbCGFiECDb32I3Y7Gmna7FqigZfR9HvCCnCz9GuHyMMfk_eH-bfaUzV8en2fTeRakMl3G9UIq7pdBmzwIxpTSCkqea6VzA9JbmRd5YFapgoVSCC2VZ8xo760Vylo5JjdDb5uajw1g56qIAdZrX0OzQSeM6gVYZooe5QMaUoOYYOnaFCufdo4zt1fpVq5X6fYq3aCyz1wf6jeLCsq_xK-7HrgbAOif_IyQHIYIdYAyJgidK5v4T_03RUKC1Q</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Antwi-Boasiako, Charles</creator><creator>Kollie, Mulbah Fasama</creator><creator>Kyeremeh, Kumi Ampaabeng</creator><creator>Osei-Tutu, Josephine Korang</creator><creator>Musah, Latif</creator><creator>Vormatu, Patience</creator><creator>Tei, Ruth Korkor</creator><creator>Hanson, Tracy</creator><creator>Sackitey-Ninye, Sylvia Esther</creator><creator>Quartey-Papafio, Theresa Ruby</creator><creator>Hayfron-Benjamin, Charles F.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0175-0340</orcidid></search><sort><creationdate>20230801</creationdate><title>Associations between spirometric measures and exercise capacity in type 2 diabetes</title><author>Antwi-Boasiako, Charles ; Kollie, Mulbah Fasama ; Kyeremeh, Kumi Ampaabeng ; Osei-Tutu, Josephine Korang ; Musah, Latif ; Vormatu, Patience ; Tei, Ruth Korkor ; Hanson, Tracy ; Sackitey-Ninye, Sylvia Esther ; Quartey-Papafio, Theresa Ruby ; Hayfron-Benjamin, Charles F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-17b341afc785c2004474ed1574758e3a93565c094460cd22734a0087aa9924993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Diabetes</topic><topic>Pulmonary function</topic><topic>Six-minute walk test</topic><topic>Spirometry</topic><topic>Submaximal exercise capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Antwi-Boasiako, Charles</creatorcontrib><creatorcontrib>Kollie, Mulbah Fasama</creatorcontrib><creatorcontrib>Kyeremeh, Kumi Ampaabeng</creatorcontrib><creatorcontrib>Osei-Tutu, Josephine Korang</creatorcontrib><creatorcontrib>Musah, Latif</creatorcontrib><creatorcontrib>Vormatu, Patience</creatorcontrib><creatorcontrib>Tei, Ruth Korkor</creatorcontrib><creatorcontrib>Hanson, Tracy</creatorcontrib><creatorcontrib>Sackitey-Ninye, Sylvia Esther</creatorcontrib><creatorcontrib>Quartey-Papafio, Theresa Ruby</creatorcontrib><creatorcontrib>Hayfron-Benjamin, Charles F.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes & metabolic syndrome clinical research & reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Antwi-Boasiako, Charles</au><au>Kollie, Mulbah Fasama</au><au>Kyeremeh, Kumi Ampaabeng</au><au>Osei-Tutu, Josephine Korang</au><au>Musah, Latif</au><au>Vormatu, Patience</au><au>Tei, Ruth Korkor</au><au>Hanson, Tracy</au><au>Sackitey-Ninye, Sylvia Esther</au><au>Quartey-Papafio, Theresa Ruby</au><au>Hayfron-Benjamin, Charles F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between spirometric measures and exercise capacity in type 2 diabetes</atitle><jtitle>Diabetes & metabolic syndrome clinical research & reviews</jtitle><addtitle>Diabetes Metab Syndr</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>17</volume><issue>8</issue><spage>102831</spage><epage>102831</epage><pages>102831-102831</pages><artnum>102831</artnum><issn>1871-4021</issn><eissn>1878-0334</eissn><abstract>Physical exercise aids glycemic control and the prevention of diabetes-related complications. However, exercise beyond an individual's pulmonary functional capacity may be detrimental. To date, little is known about the relationship between pulmonary function and exercise capacity in people with type 2 diabetes (T2D). We investigated the relationship between pulmonary function and exercise capacity in T2D.
Spirometry and 6-min walk test (6MWT) were conducted for 263 systematically sampled adults with T2D without primary heart/lung disease. The primary measure of exercise capacity was the 6-min walk distance (6MWD); impaired exercise capacity was defined as 6MWD<400 m. Logistic regression analyses were used to assess the associations between spirometric measures and exercise capacity with adjustments for age, sex, height, body mass index, diabetes duration, glycated hemoglobin concentration, smoking, suboptimum blood pressure control, and total cholesterol concentration.
Compared with individuals with normal spirometry, those with pulmonary restriction/obstruction had significantly lower 6MWD (404.67 m vs. 451.70),p < 0.001). The proportion of individuals with impaired exercise capacity was higher in individuals with impaired pulmonary function compared with those with normal pulmonary function (39.8% vs. 20.7%,p = 0.001). In the unadjusted models, decreasing Z-score FEV1 [odds ratio 1.40, 95% confidence interval (1.07–1.83),p = 0.013] and Z-score FVC [1.37 (1.06–1.76),0.016], but not Z-score FEV1/FVC ratio [1.00 (0.78–1.27),0.972] were significantly associated with impaired exercise capacity. In the fully adjusted model, the strength of association remained statistically significant for Z-score FEV1 [1.60 (1.06–2.41),0.025] but not Z-score FVC [1.48 (0.98–2.23),0.065].
Our study shows inverse associations between FEV1 and impaired exercise capacity in T2D, Future research could characterize optimal exercise levels based on a patient's FEV1.
•Impaired exercise capacity was commoner in patients with type 2 diabetes with lung dysfunction than without lung dysfunction.•Lower forced expiratory volume in 1 s was positively associated with impaired exercise capacity.•The conventional cardiovascular and respiratory risk factors did not explain the observed associations.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>37487361</pmid><doi>10.1016/j.dsx.2023.102831</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0175-0340</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Diabetes Pulmonary function Six-minute walk test Spirometry Submaximal exercise capacity |
| title | Associations between spirometric measures and exercise capacity in type 2 diabetes |
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