Gambogenic acid inhibits proliferation and ferroptosis by targeting the miR-1291/FOXA2 and AMPKα/SLC7A11/GPX4 axis in colorectal cancer

The present study aims to investigate the mechanism of the nature compound gambogenic acid (GNA) on the apoptosis and ferroptosis in colorectal cancer (CRC). The effect of GNA on the proliferation of CRC cell lines were detected by MTT and clonogenic assay. The xenograft tumor model was established,...

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Veröffentlicht in:	Cell biology international 2023-11, Vol.47 (11), p.1813-1824
Hauptverfasser:	Ma, Xiaoqi, Xu, Midie, Zhang, Xing, Wang, Xin, Su, Kexin, Xu, Zihang, Wang, Xiaoyu, Yang, Yifu
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Chemotherapy Colorectal cancer Colorectal carcinoma Endoplasmic reticulum Ferritin Ferroptosis Forkhead protein Glutathione peroxidase Iron miRNA Reactive oxygen species Transferrins Tumors
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