Intra-racial disaggregation reveals associations between nativity and overall survival in women with endometrial cancer
Prior studies have demonstrated survival differences between Black women with endometrial cancer (EC) born in the US and Caribbean. Our objective was to determine if country of birth influences EC overall survival (OS) in disaggregated subpopulations of Black women. Using the Florida Cancer Data Sys...
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| Veröffentlicht in: | Gynecologic oncology 2023-09, Vol.176, p.98-105 |
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| creator | Mercadel, Alyssa J. Sanchez-Covarrubias, Alex P. Medina, Heidy N. Pinheiro, Paulo S. Pinto, Andre George, Sophia H.L. Schlumbrecht, Matthew P. |
| description | Prior studies have demonstrated survival differences between Black women with endometrial cancer (EC) born in the US and Caribbean. Our objective was to determine if country of birth influences EC overall survival (OS) in disaggregated subpopulations of Black women.
Using the Florida Cancer Data System, women with EC diagnosed from 1981 to 2017 were identified. Demographic and clinical information were abstracted. Women who self-identified as Black and born in the US (USB), Jamaica (JBB), or Haiti (HBB) were included. Statistical analyses were performed using chi-square, Cox proportional hazards models, and Kaplan-Meier methods with significance set at p |
| doi_str_mv | 10.1016/j.ygyno.2023.07.008 |
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Using the Florida Cancer Data System, women with EC diagnosed from 1981 to 2017 were identified. Demographic and clinical information were abstracted. Women who self-identified as Black and born in the US (USB), Jamaica (JBB), or Haiti (HBB) were included. Statistical analyses were performed using chi-square, Cox proportional hazards models, and Kaplan-Meier methods with significance set at p < 0.05.
3817 women met the inclusion criteria. Compared to USB, JBB and HBB had more high-grade histologies, more advanced stage disease, had a greater proportion of uninsured or Medicaid insured, and had a higher proportion of women who received chemotherapy (all p < 0.05). In multivariate analyses, age (HR 1.03 [1.02–1.05]), regional stage (HR 1.52 [1.22–1.89]), distant stage (HR 3.73 [2.84–4.89]), lymphovascular space invasion (HR 1.96 [1.61–2.39]), receipt of surgery (HR 0.47 [0.29–0.75]), and receipt of chemotherapy (HR 0.77 [0.62–0.95]) were independently associated with OS. Compared to USB, Haitian nativity was an independent negative predictor of OS when evaluating all histologies together (HR 1.54 [1.18–2.00]) and for endometrioid EC specifically (HR 1.77 [1.10–2.83]). Among women with serous EC, HBB had markedly worse median OS (18.5 months [13.4–46.5]) relative to USB (29.9 months [26.3–35.9]) and JBB (41.0 months, [34.1–82.6], p = 0.013).
Country of birth is associated with endometrial cancer survival in Black women, with HBB demonstrating worse outcomes.
•Intra-racial disaggregation provides additional insight into health disparities found in women with endometrial cancer (EC).•Jamaican and Haitian-born Black women in the US have higher rates of high-grade EC than US-born Black women.•Haitian-born Black women in the US with serous EC experience worse overall survival than women born in Jamaica and the US.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/j.ygyno.2023.07.008</identifier><identifier>PMID: 37480810</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Ancestry ; Black women ; Caribbean women ; Endometrial cancer ; Health disparities</subject><ispartof>Gynecologic oncology, 2023-09, Vol.176, p.98-105</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-a983c0099fdbb1b70fb0932a86a17b6ec376b0ce6b56c770081d37eed0c8419b3</citedby><cites>FETCH-LOGICAL-c359t-a983c0099fdbb1b70fb0932a86a17b6ec376b0ce6b56c770081d37eed0c8419b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ygyno.2023.07.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37480810$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mercadel, Alyssa J.</creatorcontrib><creatorcontrib>Sanchez-Covarrubias, Alex P.</creatorcontrib><creatorcontrib>Medina, Heidy N.</creatorcontrib><creatorcontrib>Pinheiro, Paulo S.</creatorcontrib><creatorcontrib>Pinto, Andre</creatorcontrib><creatorcontrib>George, Sophia H.L.</creatorcontrib><creatorcontrib>Schlumbrecht, Matthew P.</creatorcontrib><title>Intra-racial disaggregation reveals associations between nativity and overall survival in women with endometrial cancer</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>Prior studies have demonstrated survival differences between Black women with endometrial cancer (EC) born in the US and Caribbean. Our objective was to determine if country of birth influences EC overall survival (OS) in disaggregated subpopulations of Black women.
Using the Florida Cancer Data System, women with EC diagnosed from 1981 to 2017 were identified. Demographic and clinical information were abstracted. Women who self-identified as Black and born in the US (USB), Jamaica (JBB), or Haiti (HBB) were included. Statistical analyses were performed using chi-square, Cox proportional hazards models, and Kaplan-Meier methods with significance set at p < 0.05.
3817 women met the inclusion criteria. Compared to USB, JBB and HBB had more high-grade histologies, more advanced stage disease, had a greater proportion of uninsured or Medicaid insured, and had a higher proportion of women who received chemotherapy (all p < 0.05). In multivariate analyses, age (HR 1.03 [1.02–1.05]), regional stage (HR 1.52 [1.22–1.89]), distant stage (HR 3.73 [2.84–4.89]), lymphovascular space invasion (HR 1.96 [1.61–2.39]), receipt of surgery (HR 0.47 [0.29–0.75]), and receipt of chemotherapy (HR 0.77 [0.62–0.95]) were independently associated with OS. Compared to USB, Haitian nativity was an independent negative predictor of OS when evaluating all histologies together (HR 1.54 [1.18–2.00]) and for endometrioid EC specifically (HR 1.77 [1.10–2.83]). Among women with serous EC, HBB had markedly worse median OS (18.5 months [13.4–46.5]) relative to USB (29.9 months [26.3–35.9]) and JBB (41.0 months, [34.1–82.6], p = 0.013).
Country of birth is associated with endometrial cancer survival in Black women, with HBB demonstrating worse outcomes.
•Intra-racial disaggregation provides additional insight into health disparities found in women with endometrial cancer (EC).•Jamaican and Haitian-born Black women in the US have higher rates of high-grade EC than US-born Black women.•Haitian-born Black women in the US with serous EC experience worse overall survival than women born in Jamaica and the US.</description><subject>Ancestry</subject><subject>Black women</subject><subject>Caribbean women</subject><subject>Endometrial cancer</subject><subject>Health disparities</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PGzEQhq2qVQkfv6BS5WMvu4zX7Np74FAhoEhIXOjZ8sckdbSxwXY2yr_HaWiPnKzxPDOv5iHkG4OWARsu1-1-tQ-x7aDjLYgWQH4iCwZj3wyyHz-TBcAIjex6eUJOc14DAAfWfSUnXFxJkAwWZPcQStJN0tbriTqf9WqVcKWLj4EmnFFPmeqcY-0f_jI1WHaIgYZaz77sqQ6OxhmTniaat2n2c93kA93FTcV2vvyhGFwtSjpkWB0spnPyZVlX48X7e0Z-390-3_xqHp_uH25-PjaW92Np9Ci5rWeMS2cMMwKWBkbeaTloJsyAlovBgMXB9IMVoipgjgtEB1ZesdHwM_LjuPclxdct5qI2PlucJh0wbrPqKgZdD91QUX5EbYo5J1yql-Q3Ou0VA3Uwrtbqr3F1MK5AqBpXp76_B2zNBt3_mX-KK3B9BLCeOXtMKluP1YHzCW1RLvoPA94AvaOWZA</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Mercadel, Alyssa J.</creator><creator>Sanchez-Covarrubias, Alex P.</creator><creator>Medina, Heidy N.</creator><creator>Pinheiro, Paulo S.</creator><creator>Pinto, Andre</creator><creator>George, Sophia H.L.</creator><creator>Schlumbrecht, Matthew P.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230901</creationdate><title>Intra-racial disaggregation reveals associations between nativity and overall survival in women with endometrial cancer</title><author>Mercadel, Alyssa J. ; Sanchez-Covarrubias, Alex P. ; Medina, Heidy N. ; Pinheiro, Paulo S. ; Pinto, Andre ; George, Sophia H.L. ; Schlumbrecht, Matthew P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-a983c0099fdbb1b70fb0932a86a17b6ec376b0ce6b56c770081d37eed0c8419b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Ancestry</topic><topic>Black women</topic><topic>Caribbean women</topic><topic>Endometrial cancer</topic><topic>Health disparities</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mercadel, Alyssa J.</creatorcontrib><creatorcontrib>Sanchez-Covarrubias, Alex P.</creatorcontrib><creatorcontrib>Medina, Heidy N.</creatorcontrib><creatorcontrib>Pinheiro, Paulo S.</creatorcontrib><creatorcontrib>Pinto, Andre</creatorcontrib><creatorcontrib>George, Sophia H.L.</creatorcontrib><creatorcontrib>Schlumbrecht, Matthew P.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mercadel, Alyssa J.</au><au>Sanchez-Covarrubias, Alex P.</au><au>Medina, Heidy N.</au><au>Pinheiro, Paulo S.</au><au>Pinto, Andre</au><au>George, Sophia H.L.</au><au>Schlumbrecht, Matthew P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intra-racial disaggregation reveals associations between nativity and overall survival in women with endometrial cancer</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>176</volume><spage>98</spage><epage>105</epage><pages>98-105</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><abstract>Prior studies have demonstrated survival differences between Black women with endometrial cancer (EC) born in the US and Caribbean. Our objective was to determine if country of birth influences EC overall survival (OS) in disaggregated subpopulations of Black women.
Using the Florida Cancer Data System, women with EC diagnosed from 1981 to 2017 were identified. Demographic and clinical information were abstracted. Women who self-identified as Black and born in the US (USB), Jamaica (JBB), or Haiti (HBB) were included. Statistical analyses were performed using chi-square, Cox proportional hazards models, and Kaplan-Meier methods with significance set at p < 0.05.
3817 women met the inclusion criteria. Compared to USB, JBB and HBB had more high-grade histologies, more advanced stage disease, had a greater proportion of uninsured or Medicaid insured, and had a higher proportion of women who received chemotherapy (all p < 0.05). In multivariate analyses, age (HR 1.03 [1.02–1.05]), regional stage (HR 1.52 [1.22–1.89]), distant stage (HR 3.73 [2.84–4.89]), lymphovascular space invasion (HR 1.96 [1.61–2.39]), receipt of surgery (HR 0.47 [0.29–0.75]), and receipt of chemotherapy (HR 0.77 [0.62–0.95]) were independently associated with OS. Compared to USB, Haitian nativity was an independent negative predictor of OS when evaluating all histologies together (HR 1.54 [1.18–2.00]) and for endometrioid EC specifically (HR 1.77 [1.10–2.83]). Among women with serous EC, HBB had markedly worse median OS (18.5 months [13.4–46.5]) relative to USB (29.9 months [26.3–35.9]) and JBB (41.0 months, [34.1–82.6], p = 0.013).
Country of birth is associated with endometrial cancer survival in Black women, with HBB demonstrating worse outcomes.
•Intra-racial disaggregation provides additional insight into health disparities found in women with endometrial cancer (EC).•Jamaican and Haitian-born Black women in the US have higher rates of high-grade EC than US-born Black women.•Haitian-born Black women in the US with serous EC experience worse overall survival than women born in Jamaica and the US.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37480810</pmid><doi>10.1016/j.ygyno.2023.07.008</doi><tpages>8</tpages></addata></record> |
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| subjects | Ancestry Black women Caribbean women Endometrial cancer Health disparities |
| title | Intra-racial disaggregation reveals associations between nativity and overall survival in women with endometrial cancer |
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