3-Indolepropionic acid mitigates sub-acute toxicity in the cardiomyocytes of epirubicin-treated female rats

Epirubicin (EPI) is an effective chemotherapeutic against breast cancer, though EPI-related cardiotoxicity limits its usage. Endogenously derived 3-indolepropionic acid ( 3-IPA) from tryptophan metabolism is of interest due to its antioxidant capabilities which may have cardioprotective effects. Sup...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2024, Vol.397 (1), p.507-520
Hauptverfasser:	Owumi, Solomon, Arunsi, Uche, Otunla, Moses, Adebisi, Grace, Altayyar, Ahmad, Irozuru, Chioma
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxydeoxyguanosine Acute toxicity Alanine transaminase Antioxidants Biomarkers Biomedical and Life Sciences Biomedicine Breast cancer Cardiomyocytes Cardiotoxicity Chemotherapy Cholesterol Deoxyguanosine Enzyme-linked immunosorbent assay Epirubicin Heart Inflammation L-Lactate dehydrogenase Lipid peroxidation Lipids Neurosciences Nitric oxide Peroxidase Pharmacology/Toxicology Reactive nitrogen species Reactive oxygen species Toxicity Triglycerides Troponin Troponin T Tryptophan
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