Cdk5-Mediated Brain Unfolded Protein Response Upregulation Associated with Cognitive Impairments in Type 2 Diabetes and Ameliorative Action of NAC

The role of cyclin-dependent kinase 5 (Cdk5) in the normal functioning of the central nervous system and synaptic plasticity is well established. However, dysregulated kinase activity can have a significant impact on neurodegeneration and cognitive impairment. Cdk5 hyperactivation is linked to diabe...

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Veröffentlicht in:ACS chemical neuroscience 2023-08, Vol.14 (15), p.2761-2774
Hauptverfasser: Saha, Debarpita, Paul, Sangita, Gaharwar, Utkarsh, Priya, Anshu, Neog, Anindita, Singh, Archana, BK, Binukumar
Format: Artikel
Sprache:eng
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