Radiobiological modelling of radiation-induced acute skin toxicity (dermatitis): A single institutional study of breast carcinoma
Purpose: The purpose of the study was to estimate the fitting parameters of the sigmoidal dose response (SDR) curve of radiation-induced acute dermatitis in breast cancer patients treated with intensity-modulated radiation therapy for calculation of normal tissue complication probability (NTCP). Mat...
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| Veröffentlicht in: | Journal of cancer research and therapeutics 2023-07, Vol.19 (3), p.738-744 |
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| creator | Singh, Balbir Singh, Gaganpreet Oinam, Arun Singh, Maninder Katake, Ajay Kumar, Vivek Vashistha, Rajesh Singh, Pankaj Mahajan, Rohit |
| description | Purpose: The purpose of the study was to estimate the fitting parameters of the sigmoidal dose response (SDR) curve of radiation-induced acute dermatitis in breast cancer patients treated with intensity-modulated radiation therapy for calculation of normal tissue complication probability (NTCP).
Materials and Methods: Twenty-five breast cancer patients were enrolled to model the SDR curve for acute dermatitis. The acute radiation-induced (ARI) dermatitis toxicity was assessed weekly for all the patients, and their scores were determined using the common terminology criterion adverse events version 5.0. The radiobiological parameters n, m, TD50, and γ50 were derived using the fitted SDR curve obtained from breast cancer Patient's clinical data.
Results: ARI dermatitis toxicity in carcinoma of breast patients was calculated for the end point of acute dermatitis. The n, m, TD50, and γ50 parameters from the SDR curve of Grade-1 dermatitis are found to be 0.03, 0.04, 28.65 ± 1.43 (confidence interval [CI] 95%) and 1.02 and for Grade-2 dermatitis are found to be 0.026, 0.028, 38.65 ± 1.93 (CI. 95%) and 1.01 respectively.
Conclusion: This research presents the fitting parameters for NTCP calculation of Grade-1 and Grade-2 acute radiation-induced skin toxicity in breast cancer for the dermatitis end point. The presented nomograms of volume versus complication probability and dose versus complication probability assist radiation oncologists in establishing the limiting dose to reduce acute toxicities for different grades of acute dermatitis in breast cancer patients. |
| doi_str_mv | 10.4103/jcrt.jcrt_1844_21 |
| format | Article |
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Materials and Methods: Twenty-five breast cancer patients were enrolled to model the SDR curve for acute dermatitis. The acute radiation-induced (ARI) dermatitis toxicity was assessed weekly for all the patients, and their scores were determined using the common terminology criterion adverse events version 5.0. The radiobiological parameters n, m, TD50, and γ50 were derived using the fitted SDR curve obtained from breast cancer Patient's clinical data.
Results: ARI dermatitis toxicity in carcinoma of breast patients was calculated for the end point of acute dermatitis. The n, m, TD50, and γ50 parameters from the SDR curve of Grade-1 dermatitis are found to be 0.03, 0.04, 28.65 ± 1.43 (confidence interval [CI] 95%) and 1.02 and for Grade-2 dermatitis are found to be 0.026, 0.028, 38.65 ± 1.93 (CI. 95%) and 1.01 respectively.
Conclusion: This research presents the fitting parameters for NTCP calculation of Grade-1 and Grade-2 acute radiation-induced skin toxicity in breast cancer for the dermatitis end point. The presented nomograms of volume versus complication probability and dose versus complication probability assist radiation oncologists in establishing the limiting dose to reduce acute toxicities for different grades of acute dermatitis in breast cancer patients.</description><identifier>ISSN: 0973-1482</identifier><identifier>EISSN: 1998-4138</identifier><identifier>DOI: 10.4103/jcrt.jcrt_1844_21</identifier><identifier>PMID: 37470603</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Analysis ; Breast cancer ; Care and treatment ; Complications and side effects ; Dermatitis ; Diagnosis ; Health aspects ; Inflammation ; Medical research ; Medicine, Experimental ; Nomograms ; Patient outcomes ; Radiation ; Radiotherapy ; Skin ; Terminology ; Toxicity</subject><ispartof>Journal of cancer research and therapeutics, 2023-07, Vol.19 (3), p.738-744</ispartof><rights>COPYRIGHT 2023 Medknow Publications and Media Pvt. Ltd.</rights><rights>2023. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c534o-58d920767d9aea7bd519d5de6b2a137e377fde72ab12888cd079d177c0a627ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27435,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37470603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Balbir</creatorcontrib><creatorcontrib>Singh, Gaganpreet</creatorcontrib><creatorcontrib>Oinam, Arun</creatorcontrib><creatorcontrib>Singh, Maninder</creatorcontrib><creatorcontrib>Katake, Ajay</creatorcontrib><creatorcontrib>Kumar, Vivek</creatorcontrib><creatorcontrib>Vashistha, Rajesh</creatorcontrib><creatorcontrib>Singh, Pankaj</creatorcontrib><creatorcontrib>Mahajan, Rohit</creatorcontrib><title>Radiobiological modelling of radiation-induced acute skin toxicity (dermatitis): A single institutional study of breast carcinoma</title><title>Journal of cancer research and therapeutics</title><addtitle>J Cancer Res Ther</addtitle><description>Purpose: The purpose of the study was to estimate the fitting parameters of the sigmoidal dose response (SDR) curve of radiation-induced acute dermatitis in breast cancer patients treated with intensity-modulated radiation therapy for calculation of normal tissue complication probability (NTCP).
Materials and Methods: Twenty-five breast cancer patients were enrolled to model the SDR curve for acute dermatitis. The acute radiation-induced (ARI) dermatitis toxicity was assessed weekly for all the patients, and their scores were determined using the common terminology criterion adverse events version 5.0. The radiobiological parameters n, m, TD50, and γ50 were derived using the fitted SDR curve obtained from breast cancer Patient's clinical data.
Results: ARI dermatitis toxicity in carcinoma of breast patients was calculated for the end point of acute dermatitis. The n, m, TD50, and γ50 parameters from the SDR curve of Grade-1 dermatitis are found to be 0.03, 0.04, 28.65 ± 1.43 (confidence interval [CI] 95%) and 1.02 and for Grade-2 dermatitis are found to be 0.026, 0.028, 38.65 ± 1.93 (CI. 95%) and 1.01 respectively.
Conclusion: This research presents the fitting parameters for NTCP calculation of Grade-1 and Grade-2 acute radiation-induced skin toxicity in breast cancer for the dermatitis end point. The presented nomograms of volume versus complication probability and dose versus complication probability assist radiation oncologists in establishing the limiting dose to reduce acute toxicities for different grades of acute dermatitis in breast cancer patients.</description><subject>Analysis</subject><subject>Breast cancer</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Dermatitis</subject><subject>Diagnosis</subject><subject>Health aspects</subject><subject>Inflammation</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Nomograms</subject><subject>Patient outcomes</subject><subject>Radiation</subject><subject>Radiotherapy</subject><subject>Skin</subject><subject>Terminology</subject><subject>Toxicity</subject><issn>0973-1482</issn><issn>1998-4138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9ks2KFDEUhQtRnHb0AdxIwM3Mosb8VSflrmkcFQYE0XVIJbeadFclY5Ki7aVvbsqekVG0NwncfOfcHDhV9ZLgK04we7M1MV_NhyKSc0XJo2pB2lbWnDD5uFrgVrCacEnPqmcpbTFuBKXyaXXGBBd4idmi-vFZWxc6F4awcUYPaAwWhsH5DQo9iuVRZxd87bydDFikzZQBpZ3zKIfvzrh8QBcW4liw7NLlW7RCqagHQM6nMptmefFNebKH2bOLoFNGRkfjfBj18-pJr4cEL-7u8-rr9bsv6w_1zaf3H9erm9o0jIe6kbalWCyFbTVo0dmGtLaxsOyoJkwAE6K3IKjuCJVSGotFa4kQBuslFZ1m59XF0fc2hm8TpKxGl0zJqj2EKSkqOaa8wZwX9PVf6DZMsaRIihHGcUNoK09ThHBWmPYUVTYKKhpKH2zc6AGU833IUZv5g2oliaSYSXGaEkuMaUsoKVT9D2oDHqIegofelfEfPDnyJoaUIvTqNrpRx4MiWM09U78q9rBnRfPqLtXUjWB_K-6LVYD1EdiHIUNMu2HaQ1SF3fmw_7-zEkyq-06yn0XB5cI</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Singh, Balbir</creator><creator>Singh, Gaganpreet</creator><creator>Oinam, Arun</creator><creator>Singh, Maninder</creator><creator>Katake, Ajay</creator><creator>Kumar, Vivek</creator><creator>Vashistha, Rajesh</creator><creator>Singh, Pankaj</creator><creator>Mahajan, Rohit</creator><general>Wolters Kluwer India Pvt. 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Academic</collection><jtitle>Journal of cancer research and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Balbir</au><au>Singh, Gaganpreet</au><au>Oinam, Arun</au><au>Singh, Maninder</au><au>Katake, Ajay</au><au>Kumar, Vivek</au><au>Vashistha, Rajesh</au><au>Singh, Pankaj</au><au>Mahajan, Rohit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiobiological modelling of radiation-induced acute skin toxicity (dermatitis): A single institutional study of breast carcinoma</atitle><jtitle>Journal of cancer research and therapeutics</jtitle><addtitle>J Cancer Res Ther</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>19</volume><issue>3</issue><spage>738</spage><epage>744</epage><pages>738-744</pages><issn>0973-1482</issn><eissn>1998-4138</eissn><abstract>Purpose: The purpose of the study was to estimate the fitting parameters of the sigmoidal dose response (SDR) curve of radiation-induced acute dermatitis in breast cancer patients treated with intensity-modulated radiation therapy for calculation of normal tissue complication probability (NTCP).
Materials and Methods: Twenty-five breast cancer patients were enrolled to model the SDR curve for acute dermatitis. The acute radiation-induced (ARI) dermatitis toxicity was assessed weekly for all the patients, and their scores were determined using the common terminology criterion adverse events version 5.0. The radiobiological parameters n, m, TD50, and γ50 were derived using the fitted SDR curve obtained from breast cancer Patient's clinical data.
Results: ARI dermatitis toxicity in carcinoma of breast patients was calculated for the end point of acute dermatitis. The n, m, TD50, and γ50 parameters from the SDR curve of Grade-1 dermatitis are found to be 0.03, 0.04, 28.65 ± 1.43 (confidence interval [CI] 95%) and 1.02 and for Grade-2 dermatitis are found to be 0.026, 0.028, 38.65 ± 1.93 (CI. 95%) and 1.01 respectively.
Conclusion: This research presents the fitting parameters for NTCP calculation of Grade-1 and Grade-2 acute radiation-induced skin toxicity in breast cancer for the dermatitis end point. The presented nomograms of volume versus complication probability and dose versus complication probability assist radiation oncologists in establishing the limiting dose to reduce acute toxicities for different grades of acute dermatitis in breast cancer patients.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>37470603</pmid><doi>10.4103/jcrt.jcrt_1844_21</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Medknow Open Access Medical Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Analysis Breast cancer Care and treatment Complications and side effects Dermatitis Diagnosis Health aspects Inflammation Medical research Medicine, Experimental Nomograms Patient outcomes Radiation Radiotherapy Skin Terminology Toxicity |
| title | Radiobiological modelling of radiation-induced acute skin toxicity (dermatitis): A single institutional study of breast carcinoma |
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