Underestimated olfactory domains in Huntington's disease: odour discrimination and threshold
Olfaction has recently found clinical value in prediction, discrimination and prognosis of some neurodegenerative disorders. However, data originating from standard tests on olfactory dysfunction in Huntington's disease are limited to odour identification, which is only one domain of olfactory...
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| Veröffentlicht in: | Journal of laryngology and otology 2024-03, Vol.138 (3), p.315-320 |
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| container_title | Journal of laryngology and otology |
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| creator | Amini, E Rohani, M Habibi, S A H Azad, Z Yazdi, N Cubo, E Hummel, T Jalessi, M |
| description | Olfaction has recently found clinical value in prediction, discrimination and prognosis of some neurodegenerative disorders. However, data originating from standard tests on olfactory dysfunction in Huntington's disease are limited to odour identification, which is only one domain of olfactory perceptual space.
Twenty-five patients and 25 age- and gender-matched controls were evaluated by the Sniffin' Sticks test in three domains of odour threshold, odour discrimination, odour identification and the sum score of them. Patients' motor function was assessed based on the Unified Huntington's Disease Rating Scale.
Compared with controls, patients' scores of all olfactory domains and their sum were significantly lower. Besides, our patients' odour threshold and odour discrimination impairments were more frequently impaired than odour identification impairment (86 per cent and 81 per cent
34 per cent, respectively).
Olfactory impairment is a common finding in patients with Huntington's disease; it is not limited to odour identification but is more pronounced in odour discrimination and odour threshold. |
| doi_str_mv | 10.1017/S002221512300124X |
| format | Article |
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Twenty-five patients and 25 age- and gender-matched controls were evaluated by the Sniffin' Sticks test in three domains of odour threshold, odour discrimination, odour identification and the sum score of them. Patients' motor function was assessed based on the Unified Huntington's Disease Rating Scale.
Compared with controls, patients' scores of all olfactory domains and their sum were significantly lower. Besides, our patients' odour threshold and odour discrimination impairments were more frequently impaired than odour identification impairment (86 per cent and 81 per cent
34 per cent, respectively).
Olfactory impairment is a common finding in patients with Huntington's disease; it is not limited to odour identification but is more pronounced in odour discrimination and odour threshold.</description><identifier>ISSN: 0022-2151</identifier><identifier>EISSN: 1748-5460</identifier><identifier>DOI: 10.1017/S002221512300124X</identifier><identifier>PMID: 37470108</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Age ; Alzheimer's disease ; Cognitive ability ; Huntington's disease ; Huntingtons disease ; Identification ; Main Article ; Movement disorders ; Neurodegenerative diseases ; Odor thresholds ; Olfaction ; Olfaction disorders ; Olfactory discrimination ; Olfactory discrimination learning ; Olfactory thresholds ; Otology ; Patients ; Womens health</subject><ispartof>Journal of laryngology and otology, 2024-03, Vol.138 (3), p.315-320</ispartof><rights>Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c325t-63846219718b07a200592fc67f782f6e55e6d943065b234cd257b0c0d28de48e3</cites><orcidid>0000-0001-6081-0353 ; 0000-0002-7223-2391</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S002221512300124X/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37470108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amini, E</creatorcontrib><creatorcontrib>Rohani, M</creatorcontrib><creatorcontrib>Habibi, S A H</creatorcontrib><creatorcontrib>Azad, Z</creatorcontrib><creatorcontrib>Yazdi, N</creatorcontrib><creatorcontrib>Cubo, E</creatorcontrib><creatorcontrib>Hummel, T</creatorcontrib><creatorcontrib>Jalessi, M</creatorcontrib><title>Underestimated olfactory domains in Huntington's disease: odour discrimination and threshold</title><title>Journal of laryngology and otology</title><addtitle>J. Laryngol. Otol</addtitle><description>Olfaction has recently found clinical value in prediction, discrimination and prognosis of some neurodegenerative disorders. However, data originating from standard tests on olfactory dysfunction in Huntington's disease are limited to odour identification, which is only one domain of olfactory perceptual space.
Twenty-five patients and 25 age- and gender-matched controls were evaluated by the Sniffin' Sticks test in three domains of odour threshold, odour discrimination, odour identification and the sum score of them. Patients' motor function was assessed based on the Unified Huntington's Disease Rating Scale.
Compared with controls, patients' scores of all olfactory domains and their sum were significantly lower. Besides, our patients' odour threshold and odour discrimination impairments were more frequently impaired than odour identification impairment (86 per cent and 81 per cent
34 per cent, respectively).
Olfactory impairment is a common finding in patients with Huntington's disease; it is not limited to odour identification but is more pronounced in odour discrimination and odour threshold.</description><subject>Age</subject><subject>Alzheimer's disease</subject><subject>Cognitive ability</subject><subject>Huntington's disease</subject><subject>Huntingtons disease</subject><subject>Identification</subject><subject>Main Article</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Odor thresholds</subject><subject>Olfaction</subject><subject>Olfaction disorders</subject><subject>Olfactory discrimination</subject><subject>Olfactory discrimination learning</subject><subject>Olfactory thresholds</subject><subject>Otology</subject><subject>Patients</subject><subject>Womens health</subject><issn>0022-2151</issn><issn>1748-5460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kE9L7TAQxYM80evVD-BGCm-hm-pkkjS57kT8B4ILFVwIJW1SjbSJL2kXfntz8arwRGYRhjnzy5xDyC6FQwpUHt0CICIVFBkARf6wRmZUclUKXsEfMluOy-V8k2yl9AJZJAE3yCaTXAIFNSOP997YaNPoBj1aU4S-0-0Y4lthwqCdT4XzxeXkR-efxuD3U2FcsjrZ4yKYMMVl20Y3OK9HF3yhvSnG5wx8Dr3ZJuud7pPdWb1zcn9-dnd6WV7fXFydnlyXLUMxlhVTvEK6kFQ1IDUCiAV2bSU7qbCrrBC2MgvOoBINMt4aFLKBFgwqY7mybE4OPrivMfybspl6yFfZvtfehinVqDgg5wJ4lv79T_qSXfh8XY0LlKCYyDUn9EPVxpBStF39mj3q-FZTqJfR1z-izzt7K_LUDNZ8bXxmnQVsBdVDE515st9__459B60RjMg</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Amini, E</creator><creator>Rohani, M</creator><creator>Habibi, S A H</creator><creator>Azad, Z</creator><creator>Yazdi, N</creator><creator>Cubo, E</creator><creator>Hummel, T</creator><creator>Jalessi, M</creator><general>Cambridge University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6081-0353</orcidid><orcidid>https://orcid.org/0000-0002-7223-2391</orcidid></search><sort><creationdate>20240301</creationdate><title>Underestimated olfactory domains in Huntington's disease: odour discrimination and threshold</title><author>Amini, E ; Rohani, M ; Habibi, S A H ; Azad, Z ; Yazdi, N ; Cubo, E ; Hummel, T ; Jalessi, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-63846219718b07a200592fc67f782f6e55e6d943065b234cd257b0c0d28de48e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age</topic><topic>Alzheimer's disease</topic><topic>Cognitive ability</topic><topic>Huntington's disease</topic><topic>Huntingtons disease</topic><topic>Identification</topic><topic>Main Article</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Odor thresholds</topic><topic>Olfaction</topic><topic>Olfaction disorders</topic><topic>Olfactory discrimination</topic><topic>Olfactory discrimination learning</topic><topic>Olfactory thresholds</topic><topic>Otology</topic><topic>Patients</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amini, E</creatorcontrib><creatorcontrib>Rohani, M</creatorcontrib><creatorcontrib>Habibi, S A H</creatorcontrib><creatorcontrib>Azad, Z</creatorcontrib><creatorcontrib>Yazdi, N</creatorcontrib><creatorcontrib>Cubo, E</creatorcontrib><creatorcontrib>Hummel, T</creatorcontrib><creatorcontrib>Jalessi, M</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of laryngology and otology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amini, E</au><au>Rohani, M</au><au>Habibi, S A H</au><au>Azad, Z</au><au>Yazdi, N</au><au>Cubo, E</au><au>Hummel, T</au><au>Jalessi, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Underestimated olfactory domains in Huntington's disease: odour discrimination and threshold</atitle><jtitle>Journal of laryngology and otology</jtitle><addtitle>J. Laryngol. Otol</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>138</volume><issue>3</issue><spage>315</spage><epage>320</epage><pages>315-320</pages><issn>0022-2151</issn><eissn>1748-5460</eissn><abstract>Olfaction has recently found clinical value in prediction, discrimination and prognosis of some neurodegenerative disorders. However, data originating from standard tests on olfactory dysfunction in Huntington's disease are limited to odour identification, which is only one domain of olfactory perceptual space.
Twenty-five patients and 25 age- and gender-matched controls were evaluated by the Sniffin' Sticks test in three domains of odour threshold, odour discrimination, odour identification and the sum score of them. Patients' motor function was assessed based on the Unified Huntington's Disease Rating Scale.
Compared with controls, patients' scores of all olfactory domains and their sum were significantly lower. Besides, our patients' odour threshold and odour discrimination impairments were more frequently impaired than odour identification impairment (86 per cent and 81 per cent
34 per cent, respectively).
Olfactory impairment is a common finding in patients with Huntington's disease; it is not limited to odour identification but is more pronounced in odour discrimination and odour threshold.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>37470108</pmid><doi>10.1017/S002221512300124X</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-6081-0353</orcidid><orcidid>https://orcid.org/0000-0002-7223-2391</orcidid></addata></record> |
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| language | eng |
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| source | Cambridge University Press Journals Complete |
| subjects | Age Alzheimer's disease Cognitive ability Huntington's disease Huntingtons disease Identification Main Article Movement disorders Neurodegenerative diseases Odor thresholds Olfaction Olfaction disorders Olfactory discrimination Olfactory discrimination learning Olfactory thresholds Otology Patients Womens health |
| title | Underestimated olfactory domains in Huntington's disease: odour discrimination and threshold |
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