Isoindigo-Based Dual-Acceptor Conjugated Polymers Incorporated Conjugation Length and Intramolecular Charge Transfer for High-Efficient Photothermal Conversion

Photothermal tumor therapy (PTT) and photoacoustic imaging (PA) have emerged as promising noninvasive diagnostic and therapeutic approaches for cancer treatment. However, the development of efficient PTT agents with high photostability and strong near-infrared (NIR) absorption remains challenging. T...

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Veröffentlicht in:Macromolecular rapid communications. 2023-10, Vol.44 (19), p.e2300244-e2300244
Hauptverfasser: Wang, Yu, Wang, Hongsen, Deng, Jinni, Pan, Yi, Zheng, Zhaohui, Ding, Xiaobin
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container_end_page e2300244
container_issue 19
container_start_page e2300244
container_title Macromolecular rapid communications.
container_volume 44
creator Wang, Yu
Wang, Hongsen
Deng, Jinni
Pan, Yi
Zheng, Zhaohui
Ding, Xiaobin
description Photothermal tumor therapy (PTT) and photoacoustic imaging (PA) have emerged as promising noninvasive diagnostic and therapeutic approaches for cancer treatment. However, the development of efficient PTT agents with high photostability and strong near-infrared (NIR) absorption remains challenging. This study synthesizes three isoindigo-based dual-acceptor conjugated polymers (CPs) (P-IIG-TPD, P-IIG-DPP, and P-IIG-EDOT-BT) via a green and nontoxic direct arylation polymerization (DArP) method and characterizes their optical, electrochemical, and NIR photothermal conversion properties. By incorporating two acceptors into the backbone, the resulting polymers exhibit enhanced photothermal conversion efficiency (PCE) due to improved synergy among conjugation length, planarity, and intramolecular charge transfer (ICT). The nanoparticles (NPs) of P-IIG-EDOT-BT and P-IIG-DPP have a uniform size distribution around 140 nm and exhibit remarkable NIR absorption at 808 nm. In addition, P-IIG-EDOT-BT and P-IIG-DPP NPs exhibit high PCEs of 62% and 78%, respectively. This study promotes the molecular design of CPs as NIR photothermal conversion materials and provides guidance for the development of novel dual-acceptor CPs for tumor diagnosis and treatment.
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source Wiley Blackwell Single Titles
subjects Absorption
Cancer therapies
Charge transfer
Conjugation
Electrochemistry
Nanoparticles
Near infrared radiation
Optical properties
Photothermal conversion
Polymers
Size distribution
Tumors
title Isoindigo-Based Dual-Acceptor Conjugated Polymers Incorporated Conjugation Length and Intramolecular Charge Transfer for High-Efficient Photothermal Conversion
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