Isoindigo-Based Dual-Acceptor Conjugated Polymers Incorporated Conjugation Length and Intramolecular Charge Transfer for High-Efficient Photothermal Conversion
Photothermal tumor therapy (PTT) and photoacoustic imaging (PA) have emerged as promising noninvasive diagnostic and therapeutic approaches for cancer treatment. However, the development of efficient PTT agents with high photostability and strong near-infrared (NIR) absorption remains challenging. T...
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Veröffentlicht in: | Macromolecular rapid communications. 2023-10, Vol.44 (19), p.e2300244-e2300244 |
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creator | Wang, Yu Wang, Hongsen Deng, Jinni Pan, Yi Zheng, Zhaohui Ding, Xiaobin |
description | Photothermal tumor therapy (PTT) and photoacoustic imaging (PA) have emerged as promising noninvasive diagnostic and therapeutic approaches for cancer treatment. However, the development of efficient PTT agents with high photostability and strong near-infrared (NIR) absorption remains challenging. This study synthesizes three isoindigo-based dual-acceptor conjugated polymers (CPs) (P-IIG-TPD, P-IIG-DPP, and P-IIG-EDOT-BT) via a green and nontoxic direct arylation polymerization (DArP) method and characterizes their optical, electrochemical, and NIR photothermal conversion properties. By incorporating two acceptors into the backbone, the resulting polymers exhibit enhanced photothermal conversion efficiency (PCE) due to improved synergy among conjugation length, planarity, and intramolecular charge transfer (ICT). The nanoparticles (NPs) of P-IIG-EDOT-BT and P-IIG-DPP have a uniform size distribution around 140 nm and exhibit remarkable NIR absorption at 808 nm. In addition, P-IIG-EDOT-BT and P-IIG-DPP NPs exhibit high PCEs of 62% and 78%, respectively. This study promotes the molecular design of CPs as NIR photothermal conversion materials and provides guidance for the development of novel dual-acceptor CPs for tumor diagnosis and treatment. |
doi_str_mv | 10.1002/marc.202300244 |
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However, the development of efficient PTT agents with high photostability and strong near-infrared (NIR) absorption remains challenging. This study synthesizes three isoindigo-based dual-acceptor conjugated polymers (CPs) (P-IIG-TPD, P-IIG-DPP, and P-IIG-EDOT-BT) via a green and nontoxic direct arylation polymerization (DArP) method and characterizes their optical, electrochemical, and NIR photothermal conversion properties. By incorporating two acceptors into the backbone, the resulting polymers exhibit enhanced photothermal conversion efficiency (PCE) due to improved synergy among conjugation length, planarity, and intramolecular charge transfer (ICT). The nanoparticles (NPs) of P-IIG-EDOT-BT and P-IIG-DPP have a uniform size distribution around 140 nm and exhibit remarkable NIR absorption at 808 nm. In addition, P-IIG-EDOT-BT and P-IIG-DPP NPs exhibit high PCEs of 62% and 78%, respectively. This study promotes the molecular design of CPs as NIR photothermal conversion materials and provides guidance for the development of novel dual-acceptor CPs for tumor diagnosis and treatment.</description><identifier>ISSN: 1022-1336</identifier><identifier>EISSN: 1521-3927</identifier><identifier>DOI: 10.1002/marc.202300244</identifier><identifier>PMID: 37465937</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Absorption ; Cancer therapies ; Charge transfer ; Conjugation ; Electrochemistry ; Nanoparticles ; Near infrared radiation ; Optical properties ; Photothermal conversion ; Polymers ; Size distribution ; Tumors</subject><ispartof>Macromolecular rapid communications., 2023-10, Vol.44 (19), p.e2300244-e2300244</ispartof><rights>2023 Wiley-VCH GmbH.</rights><rights>2023 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-77692c576dd073857ff76a784255bd8112f2923e5e3e76738b0ee8a88486274c3</citedby><cites>FETCH-LOGICAL-c323t-77692c576dd073857ff76a784255bd8112f2923e5e3e76738b0ee8a88486274c3</cites><orcidid>0000-0003-4334-3073</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37465937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Wang, Hongsen</creatorcontrib><creatorcontrib>Deng, Jinni</creatorcontrib><creatorcontrib>Pan, Yi</creatorcontrib><creatorcontrib>Zheng, Zhaohui</creatorcontrib><creatorcontrib>Ding, Xiaobin</creatorcontrib><title>Isoindigo-Based Dual-Acceptor Conjugated Polymers Incorporated Conjugation Length and Intramolecular Charge Transfer for High-Efficient Photothermal Conversion</title><title>Macromolecular rapid communications.</title><addtitle>Macromol Rapid Commun</addtitle><description>Photothermal tumor therapy (PTT) and photoacoustic imaging (PA) have emerged as promising noninvasive diagnostic and therapeutic approaches for cancer treatment. However, the development of efficient PTT agents with high photostability and strong near-infrared (NIR) absorption remains challenging. This study synthesizes three isoindigo-based dual-acceptor conjugated polymers (CPs) (P-IIG-TPD, P-IIG-DPP, and P-IIG-EDOT-BT) via a green and nontoxic direct arylation polymerization (DArP) method and characterizes their optical, electrochemical, and NIR photothermal conversion properties. By incorporating two acceptors into the backbone, the resulting polymers exhibit enhanced photothermal conversion efficiency (PCE) due to improved synergy among conjugation length, planarity, and intramolecular charge transfer (ICT). The nanoparticles (NPs) of P-IIG-EDOT-BT and P-IIG-DPP have a uniform size distribution around 140 nm and exhibit remarkable NIR absorption at 808 nm. In addition, P-IIG-EDOT-BT and P-IIG-DPP NPs exhibit high PCEs of 62% and 78%, respectively. This study promotes the molecular design of CPs as NIR photothermal conversion materials and provides guidance for the development of novel dual-acceptor CPs for tumor diagnosis and treatment.</description><subject>Absorption</subject><subject>Cancer therapies</subject><subject>Charge transfer</subject><subject>Conjugation</subject><subject>Electrochemistry</subject><subject>Nanoparticles</subject><subject>Near infrared radiation</subject><subject>Optical properties</subject><subject>Photothermal conversion</subject><subject>Polymers</subject><subject>Size distribution</subject><subject>Tumors</subject><issn>1022-1336</issn><issn>1521-3927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkctu3CAUQFHVqnm02y4rS91k4ylcbMDLdJI0I43ULNK1xeCL7ZENU8CV8jX91TB5LbridTggHUK-MLpilML3WQezAgo8L6rqHTllNbCSNyDf5zkFKBnn4oScxbinlKqKwkdywmUl6obLU_JvE_3ourH35Q8dsSuuFj2Vl8bgIflQrL3bL71O-eDOTw8zhlhsnPHh4MPT7iswelds0fVpKLTrMpOCnv2EZpl01gw69FjcB-2ixVDYrL4d-6G8tnY0I7pU3A0--TRgmPV0tP7NT2XpJ_LB6ini55fxnPy-ub5f35bbXz8368ttaTjwVEopGjC1FF1HJVe1tFYKLVUFdb3rFGNgoQGONXKUIhM7iqi0UpUSICvDz8nFs_cQ_J8FY2rnMRqcJu3QL7EFxRtZAZMqo9_-Q_d-CS7_LlOSCw5U0EytnikTfIwBbXsIY6710DLaHtO1x3TtW7p84euLdtnN2L3hr634I6wplkE</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Wang, Yu</creator><creator>Wang, Hongsen</creator><creator>Deng, Jinni</creator><creator>Pan, Yi</creator><creator>Zheng, Zhaohui</creator><creator>Ding, Xiaobin</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8FD</scope><scope>JG9</scope><scope>JQ2</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4334-3073</orcidid></search><sort><creationdate>20231001</creationdate><title>Isoindigo-Based Dual-Acceptor Conjugated Polymers Incorporated Conjugation Length and Intramolecular Charge Transfer for High-Efficient Photothermal Conversion</title><author>Wang, Yu ; Wang, Hongsen ; Deng, Jinni ; Pan, Yi ; Zheng, Zhaohui ; Ding, Xiaobin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-77692c576dd073857ff76a784255bd8112f2923e5e3e76738b0ee8a88486274c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Absorption</topic><topic>Cancer therapies</topic><topic>Charge transfer</topic><topic>Conjugation</topic><topic>Electrochemistry</topic><topic>Nanoparticles</topic><topic>Near infrared radiation</topic><topic>Optical properties</topic><topic>Photothermal conversion</topic><topic>Polymers</topic><topic>Size distribution</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Wang, Hongsen</creatorcontrib><creatorcontrib>Deng, Jinni</creatorcontrib><creatorcontrib>Pan, Yi</creatorcontrib><creatorcontrib>Zheng, Zhaohui</creatorcontrib><creatorcontrib>Ding, Xiaobin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Macromolecular rapid communications.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yu</au><au>Wang, Hongsen</au><au>Deng, Jinni</au><au>Pan, Yi</au><au>Zheng, Zhaohui</au><au>Ding, Xiaobin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isoindigo-Based Dual-Acceptor Conjugated Polymers Incorporated Conjugation Length and Intramolecular Charge Transfer for High-Efficient Photothermal Conversion</atitle><jtitle>Macromolecular rapid communications.</jtitle><addtitle>Macromol Rapid Commun</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>44</volume><issue>19</issue><spage>e2300244</spage><epage>e2300244</epage><pages>e2300244-e2300244</pages><issn>1022-1336</issn><eissn>1521-3927</eissn><abstract>Photothermal tumor therapy (PTT) and photoacoustic imaging (PA) have emerged as promising noninvasive diagnostic and therapeutic approaches for cancer treatment. However, the development of efficient PTT agents with high photostability and strong near-infrared (NIR) absorption remains challenging. This study synthesizes three isoindigo-based dual-acceptor conjugated polymers (CPs) (P-IIG-TPD, P-IIG-DPP, and P-IIG-EDOT-BT) via a green and nontoxic direct arylation polymerization (DArP) method and characterizes their optical, electrochemical, and NIR photothermal conversion properties. By incorporating two acceptors into the backbone, the resulting polymers exhibit enhanced photothermal conversion efficiency (PCE) due to improved synergy among conjugation length, planarity, and intramolecular charge transfer (ICT). The nanoparticles (NPs) of P-IIG-EDOT-BT and P-IIG-DPP have a uniform size distribution around 140 nm and exhibit remarkable NIR absorption at 808 nm. In addition, P-IIG-EDOT-BT and P-IIG-DPP NPs exhibit high PCEs of 62% and 78%, respectively. This study promotes the molecular design of CPs as NIR photothermal conversion materials and provides guidance for the development of novel dual-acceptor CPs for tumor diagnosis and treatment.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37465937</pmid><doi>10.1002/marc.202300244</doi><orcidid>https://orcid.org/0000-0003-4334-3073</orcidid></addata></record> |
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subjects | Absorption Cancer therapies Charge transfer Conjugation Electrochemistry Nanoparticles Near infrared radiation Optical properties Photothermal conversion Polymers Size distribution Tumors |
title | Isoindigo-Based Dual-Acceptor Conjugated Polymers Incorporated Conjugation Length and Intramolecular Charge Transfer for High-Efficient Photothermal Conversion |
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