The Level of Anti-Polyethylene Glycol (PEG) Immunoglobulin G Antibodies in Human Serum Does Not Correlate with Efficiency of PEGylated Nanoparticle Uptake by Monocytes

The presence of anti-polyethylene glycol (PEG) antibodies can limit the clinical efficacy of PEGylated drugs and cause anaphylactic reactions in patients. Monocytes/macrophages are effector cells involved in IgG-mediated passive systemic anaphylaxis. We studied the influence of human blood serum on...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2023-06, Vol.175 (2), p.270-274
Hauptverfasser:	Nevskaya, K. V., Krivoshchekov, S. V., Zima, A. P., Baikov, A. N., Gur’ev, A. M., Pershina, A. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphylaxis Antibodies Antigen-antibody reactions Biological products Biomedical and Life Sciences Biomedicine Biotechnologies Blood Cell Biology Drugs Effector cells Efficiency Immunization Immunoglobulin G Immunoglobulins Internal Medicine Laboratory Medicine Lipids Macrophages Monocytes Nanoparticles Pathology Peptides Polyethylene glycol Vaccines
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