Anti-Influenza Activity of Cetraria islandica Lichen Extracts in In Vitro Experiments
The toxicity and antiviral activity of extracts obtained by the methods of aqueous and ethanol extraction of bioactive substances from Cetraria islandica lichen as a raw material were studied. Aqueous and ethanol extracts of lichen were characterized by low toxicity with respect to the passaged MDCK...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2023-06, Vol.175 (2), p.215-218 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Makarevich, E. V. Filippova, E. I. Sedel’nikova, N. V. Mazurkov, O. Yu Protsenko, M. A. Shishkina, L. N. Mazurkova, N. A. |
| description | The toxicity and antiviral activity of extracts obtained by the methods of aqueous and ethanol extraction of bioactive substances from
Cetraria islandica
lichen as a raw material were studied. Aqueous and ethanol extracts of lichen were characterized by low toxicity with respect to the passaged MDCK cell culture and exhibited antiviral activity. The ethanol extract showed more potent
in vitro
antiviral activity against human A/H3N2 and avian A/H5N1 influenza viruses: in a concentration of 50 μg/ml, it suppressed replication of these viruses by 3.5 and 4 log
10
, respectively, while the aqueous extract inhibited replication of viruses by 2 and 6 log
10
, respectively, when taken in a concentration of 500 μg/ml that was 10-fold higher than the concentration of the ethanol extract. |
| doi_str_mv | 10.1007/s10517-023-05837-8 |
| format | Article |
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Cetraria islandica
lichen as a raw material were studied. Aqueous and ethanol extracts of lichen were characterized by low toxicity with respect to the passaged MDCK cell culture and exhibited antiviral activity. The ethanol extract showed more potent
in vitro
antiviral activity against human A/H3N2 and avian A/H5N1 influenza viruses: in a concentration of 50 μg/ml, it suppressed replication of these viruses by 3.5 and 4 log
10
, respectively, while the aqueous extract inhibited replication of viruses by 2 and 6 log
10
, respectively, when taken in a concentration of 500 μg/ml that was 10-fold higher than the concentration of the ethanol extract.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-023-05837-8</identifier><identifier>PMID: 37464197</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antiviral activity ; Antiviral agents ; Avian flu ; Avian influenza ; Avian influenza viruses ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Cell Biology ; Cell culture ; Cetraria islandica ; Drugs ; Enzymes ; Ethanol ; Humidity ; Infections ; Influenza ; Internal Medicine ; Laboratory Medicine ; Lichens ; Pandemics ; Pathology ; Raw materials ; Replication ; Research centers ; Toxicity ; Toxicology ; Virology ; Viruses</subject><ispartof>Bulletin of experimental biology and medicine, 2023-06, Vol.175 (2), p.215-218</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c385t-698e31f6d49e10935896a569b085f9b034c1b7bf5258e222bbe80a8c1eb1248a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-023-05837-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-023-05837-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37464197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Makarevich, E. V.</creatorcontrib><creatorcontrib>Filippova, E. I.</creatorcontrib><creatorcontrib>Sedel’nikova, N. V.</creatorcontrib><creatorcontrib>Mazurkov, O. Yu</creatorcontrib><creatorcontrib>Protsenko, M. A.</creatorcontrib><creatorcontrib>Shishkina, L. N.</creatorcontrib><creatorcontrib>Mazurkova, N. A.</creatorcontrib><title>Anti-Influenza Activity of Cetraria islandica Lichen Extracts in In Vitro Experiments</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>The toxicity and antiviral activity of extracts obtained by the methods of aqueous and ethanol extraction of bioactive substances from
Cetraria islandica
lichen as a raw material were studied. Aqueous and ethanol extracts of lichen were characterized by low toxicity with respect to the passaged MDCK cell culture and exhibited antiviral activity. The ethanol extract showed more potent
in vitro
antiviral activity against human A/H3N2 and avian A/H5N1 influenza viruses: in a concentration of 50 μg/ml, it suppressed replication of these viruses by 3.5 and 4 log
10
, respectively, while the aqueous extract inhibited replication of viruses by 2 and 6 log
10
, respectively, when taken in a concentration of 500 μg/ml that was 10-fold higher than the concentration of the ethanol extract.</description><subject>Antiviral activity</subject><subject>Antiviral agents</subject><subject>Avian flu</subject><subject>Avian influenza</subject><subject>Avian influenza viruses</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Cell Biology</subject><subject>Cell culture</subject><subject>Cetraria islandica</subject><subject>Drugs</subject><subject>Enzymes</subject><subject>Ethanol</subject><subject>Humidity</subject><subject>Infections</subject><subject>Influenza</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Lichens</subject><subject>Pandemics</subject><subject>Pathology</subject><subject>Raw materials</subject><subject>Replication</subject><subject>Research centers</subject><subject>Toxicity</subject><subject>Toxicology</subject><subject>Virology</subject><subject>Viruses</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtvEzEUhS0EoqHwB1ggS0iom6F-jF_LKColUqRuWraWZ3KncTWxg-1BlF-PhxQoXbCx5Xu_e3SuD0JvKflICVHnmRJBVUMYb4jQXDX6GVpQoXijGaPP0YJUqmm11ifoVc5385NI-hKdcNXKlhq1QDfLUHyzDsM4Qfjh8LIv_psv9zgOeAUlueQd9nl0Yet7hze-30HAF99rpy8Z-4DXAX_xJcVaPEDyewglv0YvBjdmePNwn6KbTxfXq8_N5upyvVpump5rURppNHA6yG1rgBLDhTbSCWk6osVQT972tFPdIJjQwBjrOtDE6Z5CR1mrHT9FZ0fdQ4pfJ8jF7n3uYax2IU7ZMs2N4kYzXtH3T9C7OKVQ3VWqZdIYKR9Rt24E68MQ50VnUbtUUrSCKKkr9eERtQM3ll2O41R8DPlfkB3BPsWcEwz2UH_IpXtLiZ0ztMcMbc3Q_srQzkPvHpxO3R62f0Z-h1YBfgRybYVbSH9X-Y_sT5TRo6E</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Makarevich, E. 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V. ; Mazurkov, O. Yu ; Protsenko, M. A. ; Shishkina, L. N. ; Mazurkova, N. 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Cetraria islandica
lichen as a raw material were studied. Aqueous and ethanol extracts of lichen were characterized by low toxicity with respect to the passaged MDCK cell culture and exhibited antiviral activity. The ethanol extract showed more potent
in vitro
antiviral activity against human A/H3N2 and avian A/H5N1 influenza viruses: in a concentration of 50 μg/ml, it suppressed replication of these viruses by 3.5 and 4 log
10
, respectively, while the aqueous extract inhibited replication of viruses by 2 and 6 log
10
, respectively, when taken in a concentration of 500 μg/ml that was 10-fold higher than the concentration of the ethanol extract.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37464197</pmid><doi>10.1007/s10517-023-05837-8</doi><tpages>4</tpages></addata></record> |
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| subjects | Antiviral activity Antiviral agents Avian flu Avian influenza Avian influenza viruses Biomedical and Life Sciences Biomedicine Biotechnology Cell Biology Cell culture Cetraria islandica Drugs Enzymes Ethanol Humidity Infections Influenza Internal Medicine Laboratory Medicine Lichens Pandemics Pathology Raw materials Replication Research centers Toxicity Toxicology Virology Viruses |
| title | Anti-Influenza Activity of Cetraria islandica Lichen Extracts in In Vitro Experiments |
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