Dual-Hydrogen-Bond Donor and Brønsted Acid Cocatalysis Enables Highly Enantioselective Protio-Semipinacol Rearrangement Reactions

A catalytic protio-semipinacol ring-expansion reaction has been developed for the highly enantioselective conversion of tertiary vinylic cyclopropyl alcohols into cyclobutanone products bearing α-quaternary stereogenic centers. The method relies on the cocatalytic effect of a chiral dual-hydrogen-bo...

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Veröffentlicht in:	Journal of the American Chemical Society 2023-07, Vol.145 (28), p.15036-15042
Hauptverfasser:	Blackburn, Melanie A. S., Wagen, Corin C., Bodrogean, M. Raul, Tadross, Pamela M., Bendelsmith, Andrew J., Kutateladze, Dennis A., Jacobsen, Eric N.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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