Association between overt aggression and anhedonia in patients with major depressive disorder during the acute phase
To explore the factors influencing anhedonia at baseline and use them as confounding factors. To further investigate the correlation between overt aggression and anhedonia during the acute phase of major depressive disorder. In this eight-week prospective study, 384 major depressive disorder patient...
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| Veröffentlicht in: | Journal of psychiatric research 2023-09, Vol.165, p.41-47 |
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| creator | Xu, Chuchen Wang, Fan Huang, Qinte Lyu, Dongbin Wu, Chenglin Cao, Tongdan Zhao, Jie Wang, Meiti Zhou, Ni Yang, Weichieh Chen, Yiming Wei, Zheyi Xie, Bin Hong, Wu |
| description | To explore the factors influencing anhedonia at baseline and use them as confounding factors. To further investigate the correlation between overt aggression and anhedonia during the acute phase of major depressive disorder.
In this eight-week prospective study, 384 major depressive disorder patients were recruited from the outpatient section of Shanghai Mental Health Center from May 1, 2017, to October 30, 2018. Standard treatments were performed with escitalopram or venlafaxine for participants. Depressive symptoms, overt aggression, and anhedonia were assessed using the 17-item Hamilton Rating Scale for Depression, Modified Overt Aggression Scale, and Snaith-Hamilton Pleasure Scale at baseline, and in the 4th and 8th weeks.
Obsessive-compulsive symptoms and the duration of untreated psychosis were positively associated with aggression (P |
| doi_str_mv | 10.1016/j.jpsychires.2023.07.013 |
| format | Article |
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In this eight-week prospective study, 384 major depressive disorder patients were recruited from the outpatient section of Shanghai Mental Health Center from May 1, 2017, to October 30, 2018. Standard treatments were performed with escitalopram or venlafaxine for participants. Depressive symptoms, overt aggression, and anhedonia were assessed using the 17-item Hamilton Rating Scale for Depression, Modified Overt Aggression Scale, and Snaith-Hamilton Pleasure Scale at baseline, and in the 4th and 8th weeks.
Obsessive-compulsive symptoms and the duration of untreated psychosis were positively associated with aggression (P < 0.05). Patients with aggressive behaviour had worse cognitive impairment and severe anhedonia of pleasurable sensory experiences (P < 0.05). For anhedonia, being female (tau_b = −0.23, P = 0.012) was a protective factor, while number of recurrent, melancholic features, current obsessions, previous combination drug therapies, depressive symptoms, and aggressive behaviour were risk factors (P < 0.05). Social anhedonia related to interests/pastimes, and pleasurable sensory experiences were more severe in major depressive disorder patients with aggressive behaviour in the acute phase (P < 0.05).
Anhedonia persisted in major depressive disorder patients with aggressive behaviour after standardized treatment during the acute phase. Being female protected the pleasures from social interaction and sensory experience. However, the number of depressive episodes, melancholic features, current obsessive symptoms, previous combination drug therapies, depressive symptoms, and aggressive behaviour was positively associated with anhedonia.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2023.07.013</identifier><identifier>PMID: 37459777</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><ispartof>Journal of psychiatric research, 2023-09, Vol.165, p.41-47</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c319t-362149d41e9912b6a6257363ceebadbabdc519acf51ab72e35541715f0d43cd43</cites><orcidid>0000-0002-7643-0774</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpsychires.2023.07.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37459777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Chuchen</creatorcontrib><creatorcontrib>Wang, Fan</creatorcontrib><creatorcontrib>Huang, Qinte</creatorcontrib><creatorcontrib>Lyu, Dongbin</creatorcontrib><creatorcontrib>Wu, Chenglin</creatorcontrib><creatorcontrib>Cao, Tongdan</creatorcontrib><creatorcontrib>Zhao, Jie</creatorcontrib><creatorcontrib>Wang, Meiti</creatorcontrib><creatorcontrib>Zhou, Ni</creatorcontrib><creatorcontrib>Yang, Weichieh</creatorcontrib><creatorcontrib>Chen, Yiming</creatorcontrib><creatorcontrib>Wei, Zheyi</creatorcontrib><creatorcontrib>Xie, Bin</creatorcontrib><creatorcontrib>Hong, Wu</creatorcontrib><title>Association between overt aggression and anhedonia in patients with major depressive disorder during the acute phase</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>To explore the factors influencing anhedonia at baseline and use them as confounding factors. To further investigate the correlation between overt aggression and anhedonia during the acute phase of major depressive disorder.
In this eight-week prospective study, 384 major depressive disorder patients were recruited from the outpatient section of Shanghai Mental Health Center from May 1, 2017, to October 30, 2018. Standard treatments were performed with escitalopram or venlafaxine for participants. Depressive symptoms, overt aggression, and anhedonia were assessed using the 17-item Hamilton Rating Scale for Depression, Modified Overt Aggression Scale, and Snaith-Hamilton Pleasure Scale at baseline, and in the 4th and 8th weeks.
Obsessive-compulsive symptoms and the duration of untreated psychosis were positively associated with aggression (P < 0.05). Patients with aggressive behaviour had worse cognitive impairment and severe anhedonia of pleasurable sensory experiences (P < 0.05). For anhedonia, being female (tau_b = −0.23, P = 0.012) was a protective factor, while number of recurrent, melancholic features, current obsessions, previous combination drug therapies, depressive symptoms, and aggressive behaviour were risk factors (P < 0.05). Social anhedonia related to interests/pastimes, and pleasurable sensory experiences were more severe in major depressive disorder patients with aggressive behaviour in the acute phase (P < 0.05).
Anhedonia persisted in major depressive disorder patients with aggressive behaviour after standardized treatment during the acute phase. Being female protected the pleasures from social interaction and sensory experience. However, the number of depressive episodes, melancholic features, current obsessive symptoms, previous combination drug therapies, depressive symptoms, and aggressive behaviour was positively associated with anhedonia.</description><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v1DAQhi0EotvCX0A-cknwRxyvj6XiS6rEBc6WY89uHO3GweNs1X9fL1vgyGFkyfO-78w8hFDOWs54_2FqpwUf_RgzYCuYkC3TLePyBdnwrTYNl9q8JBvGhGikUf0VuUacGGNa8O41uZK6U0ZrvSHlFjH56EpMMx2gPADMNJ0gF-r2-xqP54abQ60RQpqjo3GmSzXAXJA-xDLSo5tSpgGW3_oT0BAx5QD1b81x3tMyAnV-LUCX0SG8Ia927oDw9vm9IT8_f_px97W5__7l293tfeMlN6WRfd3WhI6DMVwMveuF0rKXHmBwYXBD8Iob53eKu0ELkEp1XHO1Y6GTvtYNeX_JXXL6tQIWe4zo4XBwM6QVrdhKI5TUW1Ol24vU54SYYWeXHI8uP1rO7Jm5new_5vbM3DJtK_Nqffc8ZR2OEP4a_0Cugo8XAdRbTxGyRV_peQg1yxcbUvz_lCdT-psZ</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Xu, Chuchen</creator><creator>Wang, Fan</creator><creator>Huang, Qinte</creator><creator>Lyu, Dongbin</creator><creator>Wu, Chenglin</creator><creator>Cao, Tongdan</creator><creator>Zhao, Jie</creator><creator>Wang, Meiti</creator><creator>Zhou, Ni</creator><creator>Yang, Weichieh</creator><creator>Chen, Yiming</creator><creator>Wei, Zheyi</creator><creator>Xie, Bin</creator><creator>Hong, Wu</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7643-0774</orcidid></search><sort><creationdate>20230901</creationdate><title>Association between overt aggression and anhedonia in patients with major depressive disorder during the acute phase</title><author>Xu, Chuchen ; Wang, Fan ; Huang, Qinte ; Lyu, Dongbin ; Wu, Chenglin ; Cao, Tongdan ; Zhao, Jie ; Wang, Meiti ; Zhou, Ni ; Yang, Weichieh ; Chen, Yiming ; Wei, Zheyi ; Xie, Bin ; Hong, Wu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-362149d41e9912b6a6257363ceebadbabdc519acf51ab72e35541715f0d43cd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Chuchen</creatorcontrib><creatorcontrib>Wang, Fan</creatorcontrib><creatorcontrib>Huang, Qinte</creatorcontrib><creatorcontrib>Lyu, Dongbin</creatorcontrib><creatorcontrib>Wu, Chenglin</creatorcontrib><creatorcontrib>Cao, Tongdan</creatorcontrib><creatorcontrib>Zhao, Jie</creatorcontrib><creatorcontrib>Wang, Meiti</creatorcontrib><creatorcontrib>Zhou, Ni</creatorcontrib><creatorcontrib>Yang, Weichieh</creatorcontrib><creatorcontrib>Chen, Yiming</creatorcontrib><creatorcontrib>Wei, Zheyi</creatorcontrib><creatorcontrib>Xie, Bin</creatorcontrib><creatorcontrib>Hong, Wu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Chuchen</au><au>Wang, Fan</au><au>Huang, Qinte</au><au>Lyu, Dongbin</au><au>Wu, Chenglin</au><au>Cao, Tongdan</au><au>Zhao, Jie</au><au>Wang, Meiti</au><au>Zhou, Ni</au><au>Yang, Weichieh</au><au>Chen, Yiming</au><au>Wei, Zheyi</au><au>Xie, Bin</au><au>Hong, Wu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between overt aggression and anhedonia in patients with major depressive disorder during the acute phase</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>165</volume><spage>41</spage><epage>47</epage><pages>41-47</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><abstract>To explore the factors influencing anhedonia at baseline and use them as confounding factors. To further investigate the correlation between overt aggression and anhedonia during the acute phase of major depressive disorder.
In this eight-week prospective study, 384 major depressive disorder patients were recruited from the outpatient section of Shanghai Mental Health Center from May 1, 2017, to October 30, 2018. Standard treatments were performed with escitalopram or venlafaxine for participants. Depressive symptoms, overt aggression, and anhedonia were assessed using the 17-item Hamilton Rating Scale for Depression, Modified Overt Aggression Scale, and Snaith-Hamilton Pleasure Scale at baseline, and in the 4th and 8th weeks.
Obsessive-compulsive symptoms and the duration of untreated psychosis were positively associated with aggression (P < 0.05). Patients with aggressive behaviour had worse cognitive impairment and severe anhedonia of pleasurable sensory experiences (P < 0.05). For anhedonia, being female (tau_b = −0.23, P = 0.012) was a protective factor, while number of recurrent, melancholic features, current obsessions, previous combination drug therapies, depressive symptoms, and aggressive behaviour were risk factors (P < 0.05). Social anhedonia related to interests/pastimes, and pleasurable sensory experiences were more severe in major depressive disorder patients with aggressive behaviour in the acute phase (P < 0.05).
Anhedonia persisted in major depressive disorder patients with aggressive behaviour after standardized treatment during the acute phase. Being female protected the pleasures from social interaction and sensory experience. However, the number of depressive episodes, melancholic features, current obsessive symptoms, previous combination drug therapies, depressive symptoms, and aggressive behaviour was positively associated with anhedonia.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37459777</pmid><doi>10.1016/j.jpsychires.2023.07.013</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7643-0774</orcidid></addata></record> |
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| title | Association between overt aggression and anhedonia in patients with major depressive disorder during the acute phase |
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