LDLR heterozygous deletion reduces hamster testicular cholesterol toxicity via AMPK/Sirt1/PGC-1α pathway

Cholesterol is an important part of the human diet. The relationship and molecular mechanisms between intracellular cholesterol and male infertility are unclear. The purpose of this study was to evaluate the role of low-density lipoprotein receptor (LDLR) in male infertility. Both wild-type (WT) and...

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Veröffentlicht in:	Toxicology letters 2023-08, Vol.384, p.30-43
Hauptverfasser:	Bai, Yun, Hei, Naiheng, Gao, Mingming, Dong, Xiaohui, Li, Mingzhao, Jiang, Shaohao, Zhang, Lianshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholesterol toxicity Golden Syrian hamster LDLR p-AMPK PGC-1α Sirt1 Testis
Online-Zugang:	Volltext
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