Separation and quantitative estimation of stereo-selective enantiomers of montelukast in pharmaceutical drug substance and tablets dosage forms by using stability-indicating normal phase-HPLC method

Montelukast sodium (MLS) is a leukotriene receptor antagonist that relieves asthma, bronchospasm, allergic rhinitis, and urticaria. A simple, robust, and stability-indicating normal phase high-performance liquid chromatography method was developed to separate and quantitatively estimate the S-enanti...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 2023-12, Vol.35 (12), p.952-965
Hauptverfasser:	Vadagam, Niroja, Haridasyam, Sharath Babu, Venkatanarayana, Muvvala, Lakka, Narasimha S, Chinnakadoori, Sanjeeva R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Allergic rhinitis Asthma Bronchospasm Chromatography Chromatography, High Pressure Liquid - methods Cyclopropanes Enantiomers Estimation Ethanol Hexanes High performance liquid chromatography Impurities Isomers Linearity Liquid chromatography Montelukast Pharmaceuticals Propionic acid Quinolines Regression coefficients Rhinitis Separation Solvents Stability Stereoisomerism Sulfides Tablets Urticaria
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