Postnasal drip and chronic cough in patients with chronic rhinitis treated with temperature‐controlled radiofrequency neurolysis
Objective To evaluate the contribution of postnasal drip (PND) and chronic cough (CC) to symptoms of patients with chronic rhinitis treated with temperature‐controlled radiofrequency (TCRF) neurolysis of the posterior nasal nerve (PNN), and correlate PND and CC scores with components of the reflecti...
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| Veröffentlicht in: | International forum of allergy & rhinology 2024-03, Vol.14 (3), p.621-629 |
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| creator | Gorelik, Daniel Ahmad, Jumah G. Razmi, Samuel E. Takashima, Masayoshi Yiu, Yin Thekdi, Apurva Ramanathan, Murugappan Dhanda, Aatin K. Yim, Michael T. Ahmed, Omar G. |
| description | Objective
To evaluate the contribution of postnasal drip (PND) and chronic cough (CC) to symptoms of patients with chronic rhinitis treated with temperature‐controlled radiofrequency (TCRF) neurolysis of the posterior nasal nerve (PNN), and correlate PND and CC scores with components of the reflective total nasal symptom score (rTNSS).
Methods
Pooled data from three prospective studies: two single‐arm studies and the index active treatment arm of a randomized controlled trial. Adult patients with baseline rTNSS ≥6 were treated with TCRF neurolysis at nonoverlapping regions of the PNN. PND and CC symptoms were evaluated on a 0 (none) to 3 (severe) scale.
Results
Data from 228 patients (57.9% women, 42.1% men) were included. The mean baseline rTNSS was 8.1 (95% confidence interval [CI], 7.8–8.3), which decreased to 3.2 (95% CI, 2.9–3.5) at 6 months. At baseline, 97.4% of patients had PND and 80.3% had CC. Median baseline PND and CC symptom scores were 3 (interquartile range [IQR], 2–3) and 2 (IQR, 1–2), respectively. At 6 months, this decreased to 1 (IQR, 0–2) and 0 (IQR, 0–1), respectively, showing significant improvement from baseline (both p |
| doi_str_mv | 10.1002/alr.23238 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2839251273</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2839251273</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3888-23b74759c87bc513d0ba78131ced45b582f17e847c3e00ccd02aa1933c367b853</originalsourceid><addsrcrecordid>eNp1kc9KHTEUh4NUVKyLvkAJuKmLq_k7ySxFai1caBG7DpnMub2Ruck0ySB3V3wCn7FPYuzYuxB6NufA9_HjwA-hD5ScU0LYhR3SOeOM6z10xIhgi6bV4t3uVs0hOsn5ntSRVEqqDtAhV6KhlJMj9Pg95hJstgPukx-xDT126xSDd9jF6eca-4BHWzyEkvGDL-sdTmsffPEZlwS2QD_TApsRki1Tgj-_n1wMJcVhqDTZ3sdVgl8TBLfFAaYKttnn92h_ZYcMJ6_7GP24_nx3dbNYfvvy9epyuXBca71gvFNCydZp1TlJeU86qzTl1EEvZCc1W1EFWijHgRDnesKspS3njjeq05Ifo09z7phifSIXs_HZwTDYAHHKhmneMkmZ4lU9faPexymF-p1hrRSNEE1DqnU2Wy7FnBOszJj8xqatocS8dGNqN-ZvN9X9-Jo4dRvod-a_JqpwMQsPfoDt_5PM5fJ2jnwGKKSbSA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2954644660</pqid></control><display><type>article</type><title>Postnasal drip and chronic cough in patients with chronic rhinitis treated with temperature‐controlled radiofrequency neurolysis</title><source>Wiley Journals</source><creator>Gorelik, Daniel ; Ahmad, Jumah G. ; Razmi, Samuel E. ; Takashima, Masayoshi ; Yiu, Yin ; Thekdi, Apurva ; Ramanathan, Murugappan ; Dhanda, Aatin K. ; Yim, Michael T. ; Ahmed, Omar G.</creator><creatorcontrib>Gorelik, Daniel ; Ahmad, Jumah G. ; Razmi, Samuel E. ; Takashima, Masayoshi ; Yiu, Yin ; Thekdi, Apurva ; Ramanathan, Murugappan ; Dhanda, Aatin K. ; Yim, Michael T. ; Ahmed, Omar G.</creatorcontrib><description>Objective
To evaluate the contribution of postnasal drip (PND) and chronic cough (CC) to symptoms of patients with chronic rhinitis treated with temperature‐controlled radiofrequency (TCRF) neurolysis of the posterior nasal nerve (PNN), and correlate PND and CC scores with components of the reflective total nasal symptom score (rTNSS).
Methods
Pooled data from three prospective studies: two single‐arm studies and the index active treatment arm of a randomized controlled trial. Adult patients with baseline rTNSS ≥6 were treated with TCRF neurolysis at nonoverlapping regions of the PNN. PND and CC symptoms were evaluated on a 0 (none) to 3 (severe) scale.
Results
Data from 228 patients (57.9% women, 42.1% men) were included. The mean baseline rTNSS was 8.1 (95% confidence interval [CI], 7.8–8.3), which decreased to 3.2 (95% CI, 2.9–3.5) at 6 months. At baseline, 97.4% of patients had PND and 80.3% had CC. Median baseline PND and CC symptom scores were 3 (interquartile range [IQR], 2–3) and 2 (IQR, 1–2), respectively. At 6 months, this decreased to 1 (IQR, 0–2) and 0 (IQR, 0–1), respectively, showing significant improvement from baseline (both p < 0.001). Spearman correlation coefficients with components of rTNSS (rhinorrhea, congestion, itching, sneezing) were 0.16 to 0.22 for CC and 0.19 to 0.46 for PND, indicating only a weak to moderate correlation.
Conclusion
PND and CC contribute to the symptomatology of chronic rhinitis and are significantly improved after TCRF neurolysis of the PNN. The inclusion of PND and CC symptoms in a chronic rhinitis assessment instrument could provide important additional information for the characterization of the disease state and outcomes after any therapeutic treatment.</description><identifier>ISSN: 2042-6976</identifier><identifier>EISSN: 2042-6984</identifier><identifier>DOI: 10.1002/alr.23238</identifier><identifier>PMID: 37461130</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>chronic cough ; chronic rhinitis ; Cough ; posterior nasal nerve ; postnasal drip ; Rhinitis ; rTNSS ; temperature‐controlled radiofrequency neurolysis</subject><ispartof>International forum of allergy & rhinology, 2024-03, Vol.14 (3), p.621-629</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.</rights><rights>2023 The Authors. International Forum of Allergy & Rhinology published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3888-23b74759c87bc513d0ba78131ced45b582f17e847c3e00ccd02aa1933c367b853</citedby><cites>FETCH-LOGICAL-c3888-23b74759c87bc513d0ba78131ced45b582f17e847c3e00ccd02aa1933c367b853</cites><orcidid>0000-0001-7998-6949 ; 0000-0001-5156-8251</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Falr.23238$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Falr.23238$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37461130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gorelik, Daniel</creatorcontrib><creatorcontrib>Ahmad, Jumah G.</creatorcontrib><creatorcontrib>Razmi, Samuel E.</creatorcontrib><creatorcontrib>Takashima, Masayoshi</creatorcontrib><creatorcontrib>Yiu, Yin</creatorcontrib><creatorcontrib>Thekdi, Apurva</creatorcontrib><creatorcontrib>Ramanathan, Murugappan</creatorcontrib><creatorcontrib>Dhanda, Aatin K.</creatorcontrib><creatorcontrib>Yim, Michael T.</creatorcontrib><creatorcontrib>Ahmed, Omar G.</creatorcontrib><title>Postnasal drip and chronic cough in patients with chronic rhinitis treated with temperature‐controlled radiofrequency neurolysis</title><title>International forum of allergy & rhinology</title><addtitle>Int Forum Allergy Rhinol</addtitle><description>Objective
To evaluate the contribution of postnasal drip (PND) and chronic cough (CC) to symptoms of patients with chronic rhinitis treated with temperature‐controlled radiofrequency (TCRF) neurolysis of the posterior nasal nerve (PNN), and correlate PND and CC scores with components of the reflective total nasal symptom score (rTNSS).
Methods
Pooled data from three prospective studies: two single‐arm studies and the index active treatment arm of a randomized controlled trial. Adult patients with baseline rTNSS ≥6 were treated with TCRF neurolysis at nonoverlapping regions of the PNN. PND and CC symptoms were evaluated on a 0 (none) to 3 (severe) scale.
Results
Data from 228 patients (57.9% women, 42.1% men) were included. The mean baseline rTNSS was 8.1 (95% confidence interval [CI], 7.8–8.3), which decreased to 3.2 (95% CI, 2.9–3.5) at 6 months. At baseline, 97.4% of patients had PND and 80.3% had CC. Median baseline PND and CC symptom scores were 3 (interquartile range [IQR], 2–3) and 2 (IQR, 1–2), respectively. At 6 months, this decreased to 1 (IQR, 0–2) and 0 (IQR, 0–1), respectively, showing significant improvement from baseline (both p < 0.001). Spearman correlation coefficients with components of rTNSS (rhinorrhea, congestion, itching, sneezing) were 0.16 to 0.22 for CC and 0.19 to 0.46 for PND, indicating only a weak to moderate correlation.
Conclusion
PND and CC contribute to the symptomatology of chronic rhinitis and are significantly improved after TCRF neurolysis of the PNN. The inclusion of PND and CC symptoms in a chronic rhinitis assessment instrument could provide important additional information for the characterization of the disease state and outcomes after any therapeutic treatment.</description><subject>chronic cough</subject><subject>chronic rhinitis</subject><subject>Cough</subject><subject>posterior nasal nerve</subject><subject>postnasal drip</subject><subject>Rhinitis</subject><subject>rTNSS</subject><subject>temperature‐controlled radiofrequency neurolysis</subject><issn>2042-6976</issn><issn>2042-6984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp1kc9KHTEUh4NUVKyLvkAJuKmLq_k7ySxFai1caBG7DpnMub2Ruck0ySB3V3wCn7FPYuzYuxB6NufA9_HjwA-hD5ScU0LYhR3SOeOM6z10xIhgi6bV4t3uVs0hOsn5ntSRVEqqDtAhV6KhlJMj9Pg95hJstgPukx-xDT126xSDd9jF6eca-4BHWzyEkvGDL-sdTmsffPEZlwS2QD_TApsRki1Tgj-_n1wMJcVhqDTZ3sdVgl8TBLfFAaYKttnn92h_ZYcMJ6_7GP24_nx3dbNYfvvy9epyuXBca71gvFNCydZp1TlJeU86qzTl1EEvZCc1W1EFWijHgRDnesKspS3njjeq05Ifo09z7phifSIXs_HZwTDYAHHKhmneMkmZ4lU9faPexymF-p1hrRSNEE1DqnU2Wy7FnBOszJj8xqatocS8dGNqN-ZvN9X9-Jo4dRvod-a_JqpwMQsPfoDt_5PM5fJ2jnwGKKSbSA</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Gorelik, Daniel</creator><creator>Ahmad, Jumah G.</creator><creator>Razmi, Samuel E.</creator><creator>Takashima, Masayoshi</creator><creator>Yiu, Yin</creator><creator>Thekdi, Apurva</creator><creator>Ramanathan, Murugappan</creator><creator>Dhanda, Aatin K.</creator><creator>Yim, Michael T.</creator><creator>Ahmed, Omar G.</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7998-6949</orcidid><orcidid>https://orcid.org/0000-0001-5156-8251</orcidid></search><sort><creationdate>202403</creationdate><title>Postnasal drip and chronic cough in patients with chronic rhinitis treated with temperature‐controlled radiofrequency neurolysis</title><author>Gorelik, Daniel ; Ahmad, Jumah G. ; Razmi, Samuel E. ; Takashima, Masayoshi ; Yiu, Yin ; Thekdi, Apurva ; Ramanathan, Murugappan ; Dhanda, Aatin K. ; Yim, Michael T. ; Ahmed, Omar G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3888-23b74759c87bc513d0ba78131ced45b582f17e847c3e00ccd02aa1933c367b853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>chronic cough</topic><topic>chronic rhinitis</topic><topic>Cough</topic><topic>posterior nasal nerve</topic><topic>postnasal drip</topic><topic>Rhinitis</topic><topic>rTNSS</topic><topic>temperature‐controlled radiofrequency neurolysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gorelik, Daniel</creatorcontrib><creatorcontrib>Ahmad, Jumah G.</creatorcontrib><creatorcontrib>Razmi, Samuel E.</creatorcontrib><creatorcontrib>Takashima, Masayoshi</creatorcontrib><creatorcontrib>Yiu, Yin</creatorcontrib><creatorcontrib>Thekdi, Apurva</creatorcontrib><creatorcontrib>Ramanathan, Murugappan</creatorcontrib><creatorcontrib>Dhanda, Aatin K.</creatorcontrib><creatorcontrib>Yim, Michael T.</creatorcontrib><creatorcontrib>Ahmed, Omar G.</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International forum of allergy & rhinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gorelik, Daniel</au><au>Ahmad, Jumah G.</au><au>Razmi, Samuel E.</au><au>Takashima, Masayoshi</au><au>Yiu, Yin</au><au>Thekdi, Apurva</au><au>Ramanathan, Murugappan</au><au>Dhanda, Aatin K.</au><au>Yim, Michael T.</au><au>Ahmed, Omar G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postnasal drip and chronic cough in patients with chronic rhinitis treated with temperature‐controlled radiofrequency neurolysis</atitle><jtitle>International forum of allergy & rhinology</jtitle><addtitle>Int Forum Allergy Rhinol</addtitle><date>2024-03</date><risdate>2024</risdate><volume>14</volume><issue>3</issue><spage>621</spage><epage>629</epage><pages>621-629</pages><issn>2042-6976</issn><eissn>2042-6984</eissn><abstract>Objective
To evaluate the contribution of postnasal drip (PND) and chronic cough (CC) to symptoms of patients with chronic rhinitis treated with temperature‐controlled radiofrequency (TCRF) neurolysis of the posterior nasal nerve (PNN), and correlate PND and CC scores with components of the reflective total nasal symptom score (rTNSS).
Methods
Pooled data from three prospective studies: two single‐arm studies and the index active treatment arm of a randomized controlled trial. Adult patients with baseline rTNSS ≥6 were treated with TCRF neurolysis at nonoverlapping regions of the PNN. PND and CC symptoms were evaluated on a 0 (none) to 3 (severe) scale.
Results
Data from 228 patients (57.9% women, 42.1% men) were included. The mean baseline rTNSS was 8.1 (95% confidence interval [CI], 7.8–8.3), which decreased to 3.2 (95% CI, 2.9–3.5) at 6 months. At baseline, 97.4% of patients had PND and 80.3% had CC. Median baseline PND and CC symptom scores were 3 (interquartile range [IQR], 2–3) and 2 (IQR, 1–2), respectively. At 6 months, this decreased to 1 (IQR, 0–2) and 0 (IQR, 0–1), respectively, showing significant improvement from baseline (both p < 0.001). Spearman correlation coefficients with components of rTNSS (rhinorrhea, congestion, itching, sneezing) were 0.16 to 0.22 for CC and 0.19 to 0.46 for PND, indicating only a weak to moderate correlation.
Conclusion
PND and CC contribute to the symptomatology of chronic rhinitis and are significantly improved after TCRF neurolysis of the PNN. The inclusion of PND and CC symptoms in a chronic rhinitis assessment instrument could provide important additional information for the characterization of the disease state and outcomes after any therapeutic treatment.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37461130</pmid><doi>10.1002/alr.23238</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7998-6949</orcidid><orcidid>https://orcid.org/0000-0001-5156-8251</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | chronic cough chronic rhinitis Cough posterior nasal nerve postnasal drip Rhinitis rTNSS temperature‐controlled radiofrequency neurolysis |
| title | Postnasal drip and chronic cough in patients with chronic rhinitis treated with temperature‐controlled radiofrequency neurolysis |
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