Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India
The present study shows the chemical profile, antimicrobial, antiproliferative, and apoptotic effects of Stemodia viscosa extracts. Thirteen bioactive compounds were identified in the 80 % ethanolic extract by GC/MS analysis. The acetone extract exhibited a higher content of flavonoids and phenols o...
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| Veröffentlicht in: | Chemistry & biodiversity 2023-08, Vol.20 (8), p.e202300332-n/a |
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| creator | Moyo, Alfredi A. Jagadhane, Kishor S. Bhosale, Sneha R. Patil, Devashree N. Shimpale, Vinod B. Anbhule, Prashant V. |
| description | The present study shows the chemical profile, antimicrobial, antiproliferative, and apoptotic effects of Stemodia viscosa extracts. Thirteen bioactive compounds were identified in the 80 % ethanolic extract by GC/MS analysis. The acetone extract exhibited a higher content of flavonoids and phenols of 805.10 μg QE/mg DW and 89.31 μg GAE/mg DW extracts, respectively. Furthermore, the acetone extract possessed the highest antioxidant activity (IC50=9.96 μg/mL). The 80 % ethanolic extract exhibited significant antimicrobial activity; the highest activity was observed against Staphylococcus aureus with a zone of inhibition of 25±0.51 mm, MIC value of 4 mg/mL, and MBC value of 8 mg/mL. The antiproliferative results revealed the presence of anticancer activity with an IC50=91.562 and 74.362 μg/mL against the B16F10 skin and COLO205 colon cancer cells, respectively. The flow cytometric analysis shows that the plant extracts cause cancer cell death through the induction of apoptosis. Our findings confirmed that Stemodia viscosa is a potential source of biologically active compounds. |
| doi_str_mv | 10.1002/cbdv.202300332 |
| format | Article |
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Thirteen bioactive compounds were identified in the 80 % ethanolic extract by GC/MS analysis. The acetone extract exhibited a higher content of flavonoids and phenols of 805.10 μg QE/mg DW and 89.31 μg GAE/mg DW extracts, respectively. Furthermore, the acetone extract possessed the highest antioxidant activity (IC50=9.96 μg/mL). The 80 % ethanolic extract exhibited significant antimicrobial activity; the highest activity was observed against Staphylococcus aureus with a zone of inhibition of 25±0.51 mm, MIC value of 4 mg/mL, and MBC value of 8 mg/mL. The antiproliferative results revealed the presence of anticancer activity with an IC50=91.562 and 74.362 μg/mL against the B16F10 skin and COLO205 colon cancer cells, respectively. The flow cytometric analysis shows that the plant extracts cause cancer cell death through the induction of apoptosis. Our findings confirmed that Stemodia viscosa is a potential source of biologically active compounds.</description><identifier>ISSN: 1612-1872</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.202300332</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Acetone ; Anticancer properties ; Antiinfectives and antibacterials ; Antimicrobial ; Antimicrobial activity ; antiproliferative ; Antiproliferatives ; Antitumor activity ; Apoptosis ; Bioactive compounds ; Biological activity ; Cell death ; Colon cancer ; Flavonoids ; Flow cytometry ; Phenols ; phytochemicals ; Plant extracts ; Stemodia ; Stemodia viscosa</subject><ispartof>Chemistry & biodiversity, 2023-08, Vol.20 (8), p.e202300332-n/a</ispartof><rights>2023 Wiley‐VHCA AG, Zurich, Switzerland</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3452-a603af0ded40ed75c7efeba2d341f2a545d717545ab27706b78bed7bab833ff3</cites><orcidid>0000-0001-7141-2000 ; 0000-0003-3444-8586 ; 0000-0003-1681-6349</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.202300332$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.202300332$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Moyo, Alfredi A.</creatorcontrib><creatorcontrib>Jagadhane, Kishor S.</creatorcontrib><creatorcontrib>Bhosale, Sneha R.</creatorcontrib><creatorcontrib>Patil, Devashree N.</creatorcontrib><creatorcontrib>Shimpale, Vinod B.</creatorcontrib><creatorcontrib>Anbhule, Prashant V.</creatorcontrib><title>Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India</title><title>Chemistry & biodiversity</title><description>The present study shows the chemical profile, antimicrobial, antiproliferative, and apoptotic effects of Stemodia viscosa extracts. Thirteen bioactive compounds were identified in the 80 % ethanolic extract by GC/MS analysis. The acetone extract exhibited a higher content of flavonoids and phenols of 805.10 μg QE/mg DW and 89.31 μg GAE/mg DW extracts, respectively. Furthermore, the acetone extract possessed the highest antioxidant activity (IC50=9.96 μg/mL). The 80 % ethanolic extract exhibited significant antimicrobial activity; the highest activity was observed against Staphylococcus aureus with a zone of inhibition of 25±0.51 mm, MIC value of 4 mg/mL, and MBC value of 8 mg/mL. The antiproliferative results revealed the presence of anticancer activity with an IC50=91.562 and 74.362 μg/mL against the B16F10 skin and COLO205 colon cancer cells, respectively. The flow cytometric analysis shows that the plant extracts cause cancer cell death through the induction of apoptosis. Our findings confirmed that Stemodia viscosa is a potential source of biologically active compounds.</description><subject>Acetone</subject><subject>Anticancer properties</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial</subject><subject>Antimicrobial activity</subject><subject>antiproliferative</subject><subject>Antiproliferatives</subject><subject>Antitumor activity</subject><subject>Apoptosis</subject><subject>Bioactive compounds</subject><subject>Biological activity</subject><subject>Cell death</subject><subject>Colon cancer</subject><subject>Flavonoids</subject><subject>Flow cytometry</subject><subject>Phenols</subject><subject>phytochemicals</subject><subject>Plant extracts</subject><subject>Stemodia</subject><subject>Stemodia viscosa</subject><issn>1612-1872</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkcFPwjAUxhujiYhePTfx4oFh1250OyIikpBIkOhxabdXKNlWbAfKf-CfbQkGEy-eXvve72u-vg-h65B0Q0LoXS6LbZcSyghhjJ6gVtgLaRAmCTk9njk9RxfOrTzv-0kLfU2Xu8bkS6h0Lko8tUbpUteLDu7XjfZNa6QW5eG6tqbUCqxo9BawqAvcX5t1Yxqd46FSkDcOG4VfGqhMoQXeapcbJ_DMfMrufvIGrgFb49FSeHQGC23qDh7XHr5EZ0qUDq5-ahvNH4fzwVMweR6NB_1JkLMopoHoESYUKaCICBQ8zjkokIIWLAoVFXEUFzzkvghJOSc9yRPpOSlkwphSrI1uD8_6v7xvvJ2s8iahLEUNZuMymrCUxiSKU4_e_EFXZmNrb85TcZRyFnszbdQ9UH5TzllQ2drqSthdFpJsn0u2zyU75uIF6UHwoUvY_UNng_uH11_tN14fk24</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Moyo, Alfredi A.</creator><creator>Jagadhane, Kishor S.</creator><creator>Bhosale, Sneha R.</creator><creator>Patil, Devashree N.</creator><creator>Shimpale, Vinod B.</creator><creator>Anbhule, Prashant V.</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7141-2000</orcidid><orcidid>https://orcid.org/0000-0003-3444-8586</orcidid><orcidid>https://orcid.org/0000-0003-1681-6349</orcidid></search><sort><creationdate>202308</creationdate><title>Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India</title><author>Moyo, Alfredi A. ; 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| subjects | Acetone Anticancer properties Antiinfectives and antibacterials Antimicrobial Antimicrobial activity antiproliferative Antiproliferatives Antitumor activity Apoptosis Bioactive compounds Biological activity Cell death Colon cancer Flavonoids Flow cytometry Phenols phytochemicals Plant extracts Stemodia Stemodia viscosa |
| title | Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India |
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