Long non‐coding RNA PANDAR promoted radiation and cisplatin‐induced DNA damage repair through ATR/CHK1 in NSCLC

Background DNA‐damaging agents, including radiation and platinum‐based chemotherapy, are indispensable treatments for non‐small cell lung cancer (NSCLC) patients. However, cancer cells tend to be resistant to both radiation and chemotherapy, thus resulting in treatment failure or recurrence. The pur...

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Veröffentlicht in:	The journal of gene medicine 2023-12, Vol.25 (12), p.e3565-n/a
Hauptverfasser:	Zhao, Songyun, Yu, Nanxi, Wang, Hang, Wan, Zhijie, Diao, Chaoyue, Chen, Yuanyuan, Liu, Tingting, Yang, Yanyong, Gao, Fu, Bai, Chong, Cao, Kun, Cai, Jianming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antisense DNA Antisense RNA Apoptosis Apoptosis - genetics Ataxia Telangiectasia Mutated Proteins - genetics Ataxia Telangiectasia Mutated Proteins - metabolism Ataxia Telangiectasia Mutated Proteins - therapeutic use cancer Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - therapy Cell cycle Cell Line, Tumor Cell Proliferation - genetics Cell viability cell‐therapy Chemotherapy CHK1 protein Cholecystokinin Cisplatin Cisplatin - pharmacology Comet assay DNA Damage DNA repair DNA Repair - genetics Flow cytometry Humans Immunofluorescence lung Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - therapy Mice molecular‐genetics Non-coding RNA Non-small cell lung carcinoma Phosphorylation Radiation Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Small cell lung carcinoma Therapeutic targets tumor therapy
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