Antihelminthic and antiangiogenic effects of zinc oxide nanoparticles on intestinal and muscular phases of trichinellosis
Trichinellosis is a worldwide zoonotic disease affecting a wide range of mammals, including humans. It has intestinal and muscular phases. The current work was done to experimentally evaluate the efficacy of zinc oxide nanoparticles (ZnO NPs) and their combination with albendazole on intestinal and...
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| Veröffentlicht in: | Journal of helminthology 2023-07, Vol.97, p.e56-e56, Article e56 |
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| description | Trichinellosis is a worldwide zoonotic disease affecting a wide range of mammals, including humans. It has intestinal and muscular phases. The current work was done to experimentally evaluate the efficacy of zinc oxide nanoparticles (ZnO NPs) and their combination with albendazole on intestinal and muscular stages of Trichinella spiralis (T. spiralis) infection. We had five main groups of mice: Group 1, non-infected control; Group 2, infected control; Group 3, infected and treated with albendazole; Group 4, infected and treated with ZnO NPs; and Group 5, infected and treated with albendazole and ZnO NPs. Each group was divided into two subgroups (A for the intestinal phase and B for the muscular phase). Drug effects were evaluated by parasitological, histopathological, and biochemical studies, including oxidant/antioxidant analysis and vascular endothelial growth factor (VEGF) gene expression in muscle tissue by quantitative real-time PCR. ZnO NPs resulted in a significant reduction of both intestinal and muscular phases of T. spiralis. Their combination with albendazole resulted in the complete eradication of adult worms and the maximum reduction of larval deposition in muscle tissue. Additionally, the treatment showed improvement in T. spiralis-induced pathological changes and oxidative stress status. Moreover, a significant decrease in VEGF gene expression was detected in the treated groups when compared with the infected control. In conclusion, ZnO NPs presented an antihelminthic effect against both adult and larval stages of T. spiralis. In addition, it enhanced antioxidant status and suppressed angiogenesis in muscle. |
| doi_str_mv | 10.1017/S0022149X23000421 |
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It has intestinal and muscular phases. The current work was done to experimentally evaluate the efficacy of zinc oxide nanoparticles (ZnO NPs) and their combination with albendazole on intestinal and muscular stages of Trichinella spiralis (T. spiralis) infection. We had five main groups of mice: Group 1, non-infected control; Group 2, infected control; Group 3, infected and treated with albendazole; Group 4, infected and treated with ZnO NPs; and Group 5, infected and treated with albendazole and ZnO NPs. Each group was divided into two subgroups (A for the intestinal phase and B for the muscular phase). Drug effects were evaluated by parasitological, histopathological, and biochemical studies, including oxidant/antioxidant analysis and vascular endothelial growth factor (VEGF) gene expression in muscle tissue by quantitative real-time PCR. ZnO NPs resulted in a significant reduction of both intestinal and muscular phases of T. spiralis. Their combination with albendazole resulted in the complete eradication of adult worms and the maximum reduction of larval deposition in muscle tissue. Additionally, the treatment showed improvement in T. spiralis-induced pathological changes and oxidative stress status. Moreover, a significant decrease in VEGF gene expression was detected in the treated groups when compared with the infected control. In conclusion, ZnO NPs presented an antihelminthic effect against both adult and larval stages of T. spiralis. In addition, it enhanced antioxidant status and suppressed angiogenesis in muscle.</description><identifier>ISSN: 0022-149X</identifier><identifier>EISSN: 1475-2697</identifier><identifier>DOI: 10.1017/S0022149X23000421</identifier><identifier>PMID: 37462419</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Albendazole ; Angiogenesis ; Antiangiogenics ; Antioxidants ; Gene expression ; Growth factors ; Histopathology ; Infections ; Intestine ; Laboratories ; Larvae ; Larval stage ; Microscopy ; Muscles ; Nanoparticles ; Nucleotide sequence ; Oxidants ; Oxidation ; Oxidative stress ; Oxidizing agents ; Parasites ; Phases ; Physiology ; Reduction ; Research Paper ; Subgroups ; Trichinellosis ; Vascular endothelial growth factor ; Worms ; Zinc ; Zinc oxide ; Zinc oxides ; Zoonoses</subject><ispartof>Journal of helminthology, 2023-07, Vol.97, p.e56-e56, Article e56</ispartof><rights>The Author(s), 2023. Published by Cambridge University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c325t-fb1ca00aa9379508aed8fbe917a773c7dc11d2748cde993579063cf8b162c50b3</cites><orcidid>0000-0003-3561-1904 ; 0000-0002-6017-7700</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022149X23000421/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37462419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ashoush, S.E.</creatorcontrib><creatorcontrib>Soliman, E.K.</creatorcontrib><title>Antihelminthic and antiangiogenic effects of zinc oxide nanoparticles on intestinal and muscular phases of trichinellosis</title><title>Journal of helminthology</title><addtitle>J. Helminthol</addtitle><description>Trichinellosis is a worldwide zoonotic disease affecting a wide range of mammals, including humans. It has intestinal and muscular phases. The current work was done to experimentally evaluate the efficacy of zinc oxide nanoparticles (ZnO NPs) and their combination with albendazole on intestinal and muscular stages of Trichinella spiralis (T. spiralis) infection. We had five main groups of mice: Group 1, non-infected control; Group 2, infected control; Group 3, infected and treated with albendazole; Group 4, infected and treated with ZnO NPs; and Group 5, infected and treated with albendazole and ZnO NPs. Each group was divided into two subgroups (A for the intestinal phase and B for the muscular phase). Drug effects were evaluated by parasitological, histopathological, and biochemical studies, including oxidant/antioxidant analysis and vascular endothelial growth factor (VEGF) gene expression in muscle tissue by quantitative real-time PCR. ZnO NPs resulted in a significant reduction of both intestinal and muscular phases of T. spiralis. Their combination with albendazole resulted in the complete eradication of adult worms and the maximum reduction of larval deposition in muscle tissue. Additionally, the treatment showed improvement in T. spiralis-induced pathological changes and oxidative stress status. Moreover, a significant decrease in VEGF gene expression was detected in the treated groups when compared with the infected control. In conclusion, ZnO NPs presented an antihelminthic effect against both adult and larval stages of T. spiralis. In addition, it enhanced antioxidant status and suppressed angiogenesis in muscle.</description><subject>Albendazole</subject><subject>Angiogenesis</subject><subject>Antiangiogenics</subject><subject>Antioxidants</subject><subject>Gene expression</subject><subject>Growth factors</subject><subject>Histopathology</subject><subject>Infections</subject><subject>Intestine</subject><subject>Laboratories</subject><subject>Larvae</subject><subject>Larval stage</subject><subject>Microscopy</subject><subject>Muscles</subject><subject>Nanoparticles</subject><subject>Nucleotide sequence</subject><subject>Oxidants</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Oxidizing agents</subject><subject>Parasites</subject><subject>Phases</subject><subject>Physiology</subject><subject>Reduction</subject><subject>Research Paper</subject><subject>Subgroups</subject><subject>Trichinellosis</subject><subject>Vascular endothelial growth factor</subject><subject>Worms</subject><subject>Zinc</subject><subject>Zinc oxide</subject><subject>Zinc oxides</subject><subject>Zoonoses</subject><issn>0022-149X</issn><issn>1475-2697</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kUtLxDAUhYMoOj5-gBspuHFTzaNtkuUw-ALBhQruSpreTiNtMiYtOP56M-OooLgIgZzvnHvDQeiY4HOCCb94wJhSkslnyjDGGSVbaEIynqe0kHwbTVZyutL30H4IL5FhhOa7aI_xrKAZkRO0nNrBtND1xg6t0YmydTyDUXZu3BxsfIKmAT2ExDXJu7E6cW-mhsQq6xbKD0Z3EDWbxAAIg7GqW4f0Y9Bjp3yyaFWAtXvwRrfGQte5YMIh2mlUF-Bocx-gp6vLx9lNend_fTub3qWa0XxIm4pohbFSknGZY6GgFk0FknDFOdO81oTUlGdC1yAly7nEBdONqEhBdY4rdoDOPnMX3r2OccWyN0HHJZQFN4aSCiZpJnJKI3r6C31xo48_WlOiYJmQIlLkk9LeheChKRfe9MovS4LLVS_ln16i52STPFY91N-OryIiwDahqq-8qefwM_v_2A_bJJmU</recordid><startdate>20230718</startdate><enddate>20230718</enddate><creator>Ashoush, S.E.</creator><creator>Soliman, E.K.</creator><general>Cambridge University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7SN</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H95</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3561-1904</orcidid><orcidid>https://orcid.org/0000-0002-6017-7700</orcidid></search><sort><creationdate>20230718</creationdate><title>Antihelminthic and antiangiogenic effects of zinc oxide nanoparticles on intestinal and muscular phases of trichinellosis</title><author>Ashoush, S.E. ; Soliman, E.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-fb1ca00aa9379508aed8fbe917a773c7dc11d2748cde993579063cf8b162c50b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Albendazole</topic><topic>Angiogenesis</topic><topic>Antiangiogenics</topic><topic>Antioxidants</topic><topic>Gene expression</topic><topic>Growth factors</topic><topic>Histopathology</topic><topic>Infections</topic><topic>Intestine</topic><topic>Laboratories</topic><topic>Larvae</topic><topic>Larval stage</topic><topic>Microscopy</topic><topic>Muscles</topic><topic>Nanoparticles</topic><topic>Nucleotide sequence</topic><topic>Oxidants</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Oxidizing agents</topic><topic>Parasites</topic><topic>Phases</topic><topic>Physiology</topic><topic>Reduction</topic><topic>Research Paper</topic><topic>Subgroups</topic><topic>Trichinellosis</topic><topic>Vascular endothelial growth factor</topic><topic>Worms</topic><topic>Zinc</topic><topic>Zinc oxide</topic><topic>Zinc oxides</topic><topic>Zoonoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ashoush, S.E.</creatorcontrib><creatorcontrib>Soliman, E.K.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Ecology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of helminthology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ashoush, S.E.</au><au>Soliman, E.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antihelminthic and antiangiogenic effects of zinc oxide nanoparticles on intestinal and muscular phases of trichinellosis</atitle><jtitle>Journal of helminthology</jtitle><addtitle>J. Helminthol</addtitle><date>2023-07-18</date><risdate>2023</risdate><volume>97</volume><spage>e56</spage><epage>e56</epage><pages>e56-e56</pages><artnum>e56</artnum><issn>0022-149X</issn><eissn>1475-2697</eissn><abstract>Trichinellosis is a worldwide zoonotic disease affecting a wide range of mammals, including humans. It has intestinal and muscular phases. The current work was done to experimentally evaluate the efficacy of zinc oxide nanoparticles (ZnO NPs) and their combination with albendazole on intestinal and muscular stages of Trichinella spiralis (T. spiralis) infection. We had five main groups of mice: Group 1, non-infected control; Group 2, infected control; Group 3, infected and treated with albendazole; Group 4, infected and treated with ZnO NPs; and Group 5, infected and treated with albendazole and ZnO NPs. Each group was divided into two subgroups (A for the intestinal phase and B for the muscular phase). Drug effects were evaluated by parasitological, histopathological, and biochemical studies, including oxidant/antioxidant analysis and vascular endothelial growth factor (VEGF) gene expression in muscle tissue by quantitative real-time PCR. ZnO NPs resulted in a significant reduction of both intestinal and muscular phases of T. spiralis. Their combination with albendazole resulted in the complete eradication of adult worms and the maximum reduction of larval deposition in muscle tissue. Additionally, the treatment showed improvement in T. spiralis-induced pathological changes and oxidative stress status. Moreover, a significant decrease in VEGF gene expression was detected in the treated groups when compared with the infected control. In conclusion, ZnO NPs presented an antihelminthic effect against both adult and larval stages of T. spiralis. In addition, it enhanced antioxidant status and suppressed angiogenesis in muscle.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>37462419</pmid><doi>10.1017/S0022149X23000421</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3561-1904</orcidid><orcidid>https://orcid.org/0000-0002-6017-7700</orcidid></addata></record> |
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| subjects | Albendazole Angiogenesis Antiangiogenics Antioxidants Gene expression Growth factors Histopathology Infections Intestine Laboratories Larvae Larval stage Microscopy Muscles Nanoparticles Nucleotide sequence Oxidants Oxidation Oxidative stress Oxidizing agents Parasites Phases Physiology Reduction Research Paper Subgroups Trichinellosis Vascular endothelial growth factor Worms Zinc Zinc oxide Zinc oxides Zoonoses |
| title | Antihelminthic and antiangiogenic effects of zinc oxide nanoparticles on intestinal and muscular phases of trichinellosis |
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