Praeruptorin C alleviates cognitive impairment in type 2 diabetic mice through restoring PI3K/AKT/GSK3β pathway

Diabetic encephalopathy is a common consequence of diabetes mellitus that causes cognitive dysfunction and neuropsychiatric disorders. Praeruptorin C (Pra-C) from the traditional Chinese medicinal herb Peucedanum praeruptorum Dunn. is a potential antioxidant and neuroprotective agent. This study was...

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Veröffentlicht in:	Phytotherapy research 2023-10, Vol.37 (10), p.4838-4850
Hauptverfasser:	Li, Long-Fei, Gao, Ying, Xu, Yuan, Su, Dan-Jie, Yang, Qi, Liu, An, Wang, Sai-Ying, Tang, Xiu-Ling, Zhao, Jun, Luo, Li, Yan, Tao, Wu, Yu-Mei, Liu, Shui-Bing, Zhao, Ming-Gao, Yang, Le
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Body weight Cognitive ability Diabetes Diabetes mellitus Encephalopathy Herbal medicine Hippocampal plasticity Impairment In vivo methods and tests Medicinal plants Mental disorders Molecular docking Molecular modelling Neuroprotection Object recognition Pattern recognition Pharmacology Proteins Signal transduction Synaptic plasticity Traditional Chinese medicine Western blotting
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