[18F]FNDP PET neuroimaging test–retest repeatability and whole-body dosimetry in humans
Purpose Soluble epoxide hydrolase (sEH) is an enzyme that shapes immune signaling through its role in maintaining the homeostasis of polyunsaturated fatty acids and their related byproducts. [ 18 F]FNDP is a radiotracer developed for use with positron emission tomography (PET) to image sEH, which ha...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2023-10, Vol.50 (12), p.3659-3665 |
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| creator | Du, Yong Coughlin, Jennifer M. Amindarolzarbi, Alireza Sweeney, Shannon Eileen Harrington, Courtney K. Brosnan, Mary Katherine Zandi, Adeline Shinehouse, Laura K. Sanchez, Alejandra N. Reyes Abdallah, Rehab Holt, Daniel P. Fan, Hong Lesniak, Wojciech G. Nandi, Ayon Rowe, Steven P. Solnes, Lilja B. Dannals, Robert F. Horti, Andrew G. Lodge, Martin A. Pomper, Martin G. |
| description | Purpose
Soluble epoxide hydrolase (sEH) is an enzyme that shapes immune signaling through its role in maintaining the homeostasis of polyunsaturated fatty acids and their related byproducts. [
18
F]FNDP is a radiotracer developed for use with positron emission tomography (PET) to image sEH, which has been applied to imaging sEH in the brains of healthy individuals. Here, we report the test–retest repeatability of [
18
F]FNDP brain PET binding and [
18
F]FNDP whole-body dosimetry in healthy individuals.
Methods
Seven healthy adults (4 men, 3 women, ages 40.1 ± 4.6 years) completed [
18
F]FNDP brain PET on two occasions within a period of 14 days in a test–retest study design. [
18
F]FNDP regional total distribution volume (V
T
) values were derived from modeling time-activity data with a metabolite-corrected arterial input function. Test–retest variability, mean absolute deviation, and intraclass correlation coefficient (ICC) were investigated. Six other healthy adults (3 men, 3 women, ages 46.0 ± 7.0 years) underwent [
18
F]FNDP PET/CT for whole-body dosimetry, which was acquired over 4.5 h, starting immediately after radiotracer administration. Organ-absorbed doses and the effective dose were then estimated.
Results
The mean test–retest difference in regional V
T
(ΔV
T
) was 0.82 ± 5.17%. The mean absolute difference in regional V
T
was 4.01 ± 3.33%. The ICC across different brain regions ranged from 0.92 to 0.99. The organs with the greatest radiation-absorbed doses included the gallbladder (0.081 ± 0.024 mSv/MBq), followed by liver (0.077 ± 0.018 mSv/MBq) and kidneys (0.063 ± 0.006 mSv/MBq). The effective dose was 0.020 ± 0.003 mSv/MBq.
Conclusion
These data support a favorable test–retest repeatability of [
18
F]FNDP brain PET regional V
T
. The radiation dose to humans from each [
18
F]FNDP PET scan is similar to that of other
18
F-based PET radiotracers. |
| doi_str_mv | 10.1007/s00259-023-06331-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2839246864</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2839246864</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-75b3108bef19ecb4e38bb4bc1b935fc7906b8bd79c690a6e6df0bc1ea52b1b6e3</originalsourceid><addsrcrecordid>eNp9kM1KxDAQx4Mofqy-gAcJePFSTZo2H0fRXRVEPehBRELSTtdKP9akRXZPvoNv6JOYdXUFD55mYH7zn-GH0C4lh5QQceQJiVMVkZhFhDNGo9kK2qScqkgQqVaXvSAbaMv7Z0KojKVaRxtMJKkUqdpE9w9Ujh5HV6c3-GZ4ixvoXVvWZlw2Y9yB7z7e3h3MG-xgAqYztqzKbopNk-PXp7aCyLb5FOetL2vo3BSXDX7qa9P4bbRWmMrDzncdoLvR8PbkPLq8Prs4Ob6MMhbzLhKpZZRICwVVkNkEmLQ2sRm1iqVFJhThVtpcqIwrYjjwvCBhCiaNLbUc2AAdLHInrn3pw6e6Ln0GVWUaaHuvY8lUnHDJk4Du_0Gf29414btACaoEE5IFKl5QmWu9d1DoiQtK3FRToufi9UK8DuL1l3g9C0t739G9rSFfrvyYDgBbAD6MmjG439v_xH4CTPSQHA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2871973783</pqid></control><display><type>article</type><title>[18F]FNDP PET neuroimaging test–retest repeatability and whole-body dosimetry in humans</title><source>SpringerNature Journals</source><creator>Du, Yong ; Coughlin, Jennifer M. ; Amindarolzarbi, Alireza ; Sweeney, Shannon Eileen ; Harrington, Courtney K. ; Brosnan, Mary Katherine ; Zandi, Adeline ; Shinehouse, Laura K. ; Sanchez, Alejandra N. Reyes ; Abdallah, Rehab ; Holt, Daniel P. ; Fan, Hong ; Lesniak, Wojciech G. ; Nandi, Ayon ; Rowe, Steven P. ; Solnes, Lilja B. ; Dannals, Robert F. ; Horti, Andrew G. ; Lodge, Martin A. ; Pomper, Martin G.</creator><creatorcontrib>Du, Yong ; Coughlin, Jennifer M. ; Amindarolzarbi, Alireza ; Sweeney, Shannon Eileen ; Harrington, Courtney K. ; Brosnan, Mary Katherine ; Zandi, Adeline ; Shinehouse, Laura K. ; Sanchez, Alejandra N. Reyes ; Abdallah, Rehab ; Holt, Daniel P. ; Fan, Hong ; Lesniak, Wojciech G. ; Nandi, Ayon ; Rowe, Steven P. ; Solnes, Lilja B. ; Dannals, Robert F. ; Horti, Andrew G. ; Lodge, Martin A. ; Pomper, Martin G.</creatorcontrib><description>Purpose
Soluble epoxide hydrolase (sEH) is an enzyme that shapes immune signaling through its role in maintaining the homeostasis of polyunsaturated fatty acids and their related byproducts. [
18
F]FNDP is a radiotracer developed for use with positron emission tomography (PET) to image sEH, which has been applied to imaging sEH in the brains of healthy individuals. Here, we report the test–retest repeatability of [
18
F]FNDP brain PET binding and [
18
F]FNDP whole-body dosimetry in healthy individuals.
Methods
Seven healthy adults (4 men, 3 women, ages 40.1 ± 4.6 years) completed [
18
F]FNDP brain PET on two occasions within a period of 14 days in a test–retest study design. [
18
F]FNDP regional total distribution volume (V
T
) values were derived from modeling time-activity data with a metabolite-corrected arterial input function. Test–retest variability, mean absolute deviation, and intraclass correlation coefficient (ICC) were investigated. Six other healthy adults (3 men, 3 women, ages 46.0 ± 7.0 years) underwent [
18
F]FNDP PET/CT for whole-body dosimetry, which was acquired over 4.5 h, starting immediately after radiotracer administration. Organ-absorbed doses and the effective dose were then estimated.
Results
The mean test–retest difference in regional V
T
(ΔV
T
) was 0.82 ± 5.17%. The mean absolute difference in regional V
T
was 4.01 ± 3.33%. The ICC across different brain regions ranged from 0.92 to 0.99. The organs with the greatest radiation-absorbed doses included the gallbladder (0.081 ± 0.024 mSv/MBq), followed by liver (0.077 ± 0.018 mSv/MBq) and kidneys (0.063 ± 0.006 mSv/MBq). The effective dose was 0.020 ± 0.003 mSv/MBq.
Conclusion
These data support a favorable test–retest repeatability of [
18
F]FNDP brain PET regional V
T
. The radiation dose to humans from each [
18
F]FNDP PET scan is similar to that of other
18
F-based PET radiotracers.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-023-06331-z</identifier><identifier>PMID: 37458759</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adults ; Brain ; Cardiology ; Correlation coefficients ; Dosimeters ; Dosimetry ; Epoxide hydrolase ; Fatty acids ; Fluorine isotopes ; Gallbladder ; Homeostasis ; Imaging ; Medical imaging ; Medicine ; Medicine & Public Health ; Men ; Metabolites ; Neuroimaging ; Nuclear Medicine ; Oncology ; Original Article ; Orthopedics ; Polyunsaturated fatty acids ; Positron emission ; Positron emission tomography ; Radiation ; Radiation dosage ; Radioactive tracers ; Radiology ; Reproducibility ; Staphylococcal enterotoxin H ; Women</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2023-10, Vol.50 (12), p.3659-3665</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-75b3108bef19ecb4e38bb4bc1b935fc7906b8bd79c690a6e6df0bc1ea52b1b6e3</cites><orcidid>0000-0001-6753-3010</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-023-06331-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-023-06331-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37458759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Du, Yong</creatorcontrib><creatorcontrib>Coughlin, Jennifer M.</creatorcontrib><creatorcontrib>Amindarolzarbi, Alireza</creatorcontrib><creatorcontrib>Sweeney, Shannon Eileen</creatorcontrib><creatorcontrib>Harrington, Courtney K.</creatorcontrib><creatorcontrib>Brosnan, Mary Katherine</creatorcontrib><creatorcontrib>Zandi, Adeline</creatorcontrib><creatorcontrib>Shinehouse, Laura K.</creatorcontrib><creatorcontrib>Sanchez, Alejandra N. Reyes</creatorcontrib><creatorcontrib>Abdallah, Rehab</creatorcontrib><creatorcontrib>Holt, Daniel P.</creatorcontrib><creatorcontrib>Fan, Hong</creatorcontrib><creatorcontrib>Lesniak, Wojciech G.</creatorcontrib><creatorcontrib>Nandi, Ayon</creatorcontrib><creatorcontrib>Rowe, Steven P.</creatorcontrib><creatorcontrib>Solnes, Lilja B.</creatorcontrib><creatorcontrib>Dannals, Robert F.</creatorcontrib><creatorcontrib>Horti, Andrew G.</creatorcontrib><creatorcontrib>Lodge, Martin A.</creatorcontrib><creatorcontrib>Pomper, Martin G.</creatorcontrib><title>[18F]FNDP PET neuroimaging test–retest repeatability and whole-body dosimetry in humans</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
Soluble epoxide hydrolase (sEH) is an enzyme that shapes immune signaling through its role in maintaining the homeostasis of polyunsaturated fatty acids and their related byproducts. [
18
F]FNDP is a radiotracer developed for use with positron emission tomography (PET) to image sEH, which has been applied to imaging sEH in the brains of healthy individuals. Here, we report the test–retest repeatability of [
18
F]FNDP brain PET binding and [
18
F]FNDP whole-body dosimetry in healthy individuals.
Methods
Seven healthy adults (4 men, 3 women, ages 40.1 ± 4.6 years) completed [
18
F]FNDP brain PET on two occasions within a period of 14 days in a test–retest study design. [
18
F]FNDP regional total distribution volume (V
T
) values were derived from modeling time-activity data with a metabolite-corrected arterial input function. Test–retest variability, mean absolute deviation, and intraclass correlation coefficient (ICC) were investigated. Six other healthy adults (3 men, 3 women, ages 46.0 ± 7.0 years) underwent [
18
F]FNDP PET/CT for whole-body dosimetry, which was acquired over 4.5 h, starting immediately after radiotracer administration. Organ-absorbed doses and the effective dose were then estimated.
Results
The mean test–retest difference in regional V
T
(ΔV
T
) was 0.82 ± 5.17%. The mean absolute difference in regional V
T
was 4.01 ± 3.33%. The ICC across different brain regions ranged from 0.92 to 0.99. The organs with the greatest radiation-absorbed doses included the gallbladder (0.081 ± 0.024 mSv/MBq), followed by liver (0.077 ± 0.018 mSv/MBq) and kidneys (0.063 ± 0.006 mSv/MBq). The effective dose was 0.020 ± 0.003 mSv/MBq.
Conclusion
These data support a favorable test–retest repeatability of [
18
F]FNDP brain PET regional V
T
. The radiation dose to humans from each [
18
F]FNDP PET scan is similar to that of other
18
F-based PET radiotracers.</description><subject>Adults</subject><subject>Brain</subject><subject>Cardiology</subject><subject>Correlation coefficients</subject><subject>Dosimeters</subject><subject>Dosimetry</subject><subject>Epoxide hydrolase</subject><subject>Fatty acids</subject><subject>Fluorine isotopes</subject><subject>Gallbladder</subject><subject>Homeostasis</subject><subject>Imaging</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Men</subject><subject>Metabolites</subject><subject>Neuroimaging</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Polyunsaturated fatty acids</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Radiation</subject><subject>Radiation dosage</subject><subject>Radioactive tracers</subject><subject>Radiology</subject><subject>Reproducibility</subject><subject>Staphylococcal enterotoxin H</subject><subject>Women</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kM1KxDAQx4Mofqy-gAcJePFSTZo2H0fRXRVEPehBRELSTtdKP9akRXZPvoNv6JOYdXUFD55mYH7zn-GH0C4lh5QQceQJiVMVkZhFhDNGo9kK2qScqkgQqVaXvSAbaMv7Z0KojKVaRxtMJKkUqdpE9w9Ujh5HV6c3-GZ4ixvoXVvWZlw2Y9yB7z7e3h3MG-xgAqYztqzKbopNk-PXp7aCyLb5FOetL2vo3BSXDX7qa9P4bbRWmMrDzncdoLvR8PbkPLq8Prs4Ob6MMhbzLhKpZZRICwVVkNkEmLQ2sRm1iqVFJhThVtpcqIwrYjjwvCBhCiaNLbUc2AAdLHInrn3pw6e6Ln0GVWUaaHuvY8lUnHDJk4Du_0Gf29414btACaoEE5IFKl5QmWu9d1DoiQtK3FRToufi9UK8DuL1l3g9C0t739G9rSFfrvyYDgBbAD6MmjG439v_xH4CTPSQHA</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Du, Yong</creator><creator>Coughlin, Jennifer M.</creator><creator>Amindarolzarbi, Alireza</creator><creator>Sweeney, Shannon Eileen</creator><creator>Harrington, Courtney K.</creator><creator>Brosnan, Mary Katherine</creator><creator>Zandi, Adeline</creator><creator>Shinehouse, Laura K.</creator><creator>Sanchez, Alejandra N. Reyes</creator><creator>Abdallah, Rehab</creator><creator>Holt, Daniel P.</creator><creator>Fan, Hong</creator><creator>Lesniak, Wojciech G.</creator><creator>Nandi, Ayon</creator><creator>Rowe, Steven P.</creator><creator>Solnes, Lilja B.</creator><creator>Dannals, Robert F.</creator><creator>Horti, Andrew G.</creator><creator>Lodge, Martin A.</creator><creator>Pomper, Martin G.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6753-3010</orcidid></search><sort><creationdate>20231001</creationdate><title>[18F]FNDP PET neuroimaging test–retest repeatability and whole-body dosimetry in humans</title><author>Du, Yong ; Coughlin, Jennifer M. ; Amindarolzarbi, Alireza ; Sweeney, Shannon Eileen ; Harrington, Courtney K. ; Brosnan, Mary Katherine ; Zandi, Adeline ; Shinehouse, Laura K. ; Sanchez, Alejandra N. Reyes ; Abdallah, Rehab ; Holt, Daniel P. ; Fan, Hong ; Lesniak, Wojciech G. ; Nandi, Ayon ; Rowe, Steven P. ; Solnes, Lilja B. ; Dannals, Robert F. ; Horti, Andrew G. ; Lodge, Martin A. ; Pomper, Martin G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-75b3108bef19ecb4e38bb4bc1b935fc7906b8bd79c690a6e6df0bc1ea52b1b6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adults</topic><topic>Brain</topic><topic>Cardiology</topic><topic>Correlation coefficients</topic><topic>Dosimeters</topic><topic>Dosimetry</topic><topic>Epoxide hydrolase</topic><topic>Fatty acids</topic><topic>Fluorine isotopes</topic><topic>Gallbladder</topic><topic>Homeostasis</topic><topic>Imaging</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Men</topic><topic>Metabolites</topic><topic>Neuroimaging</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Polyunsaturated fatty acids</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Radiation</topic><topic>Radiation dosage</topic><topic>Radioactive tracers</topic><topic>Radiology</topic><topic>Reproducibility</topic><topic>Staphylococcal enterotoxin H</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Yong</creatorcontrib><creatorcontrib>Coughlin, Jennifer M.</creatorcontrib><creatorcontrib>Amindarolzarbi, Alireza</creatorcontrib><creatorcontrib>Sweeney, Shannon Eileen</creatorcontrib><creatorcontrib>Harrington, Courtney K.</creatorcontrib><creatorcontrib>Brosnan, Mary Katherine</creatorcontrib><creatorcontrib>Zandi, Adeline</creatorcontrib><creatorcontrib>Shinehouse, Laura K.</creatorcontrib><creatorcontrib>Sanchez, Alejandra N. Reyes</creatorcontrib><creatorcontrib>Abdallah, Rehab</creatorcontrib><creatorcontrib>Holt, Daniel P.</creatorcontrib><creatorcontrib>Fan, Hong</creatorcontrib><creatorcontrib>Lesniak, Wojciech G.</creatorcontrib><creatorcontrib>Nandi, Ayon</creatorcontrib><creatorcontrib>Rowe, Steven P.</creatorcontrib><creatorcontrib>Solnes, Lilja B.</creatorcontrib><creatorcontrib>Dannals, Robert F.</creatorcontrib><creatorcontrib>Horti, Andrew G.</creatorcontrib><creatorcontrib>Lodge, Martin A.</creatorcontrib><creatorcontrib>Pomper, Martin G.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Yong</au><au>Coughlin, Jennifer M.</au><au>Amindarolzarbi, Alireza</au><au>Sweeney, Shannon Eileen</au><au>Harrington, Courtney K.</au><au>Brosnan, Mary Katherine</au><au>Zandi, Adeline</au><au>Shinehouse, Laura K.</au><au>Sanchez, Alejandra N. Reyes</au><au>Abdallah, Rehab</au><au>Holt, Daniel P.</au><au>Fan, Hong</au><au>Lesniak, Wojciech G.</au><au>Nandi, Ayon</au><au>Rowe, Steven P.</au><au>Solnes, Lilja B.</au><au>Dannals, Robert F.</au><au>Horti, Andrew G.</au><au>Lodge, Martin A.</au><au>Pomper, Martin G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>[18F]FNDP PET neuroimaging test–retest repeatability and whole-body dosimetry in humans</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>50</volume><issue>12</issue><spage>3659</spage><epage>3665</epage><pages>3659-3665</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
Soluble epoxide hydrolase (sEH) is an enzyme that shapes immune signaling through its role in maintaining the homeostasis of polyunsaturated fatty acids and their related byproducts. [
18
F]FNDP is a radiotracer developed for use with positron emission tomography (PET) to image sEH, which has been applied to imaging sEH in the brains of healthy individuals. Here, we report the test–retest repeatability of [
18
F]FNDP brain PET binding and [
18
F]FNDP whole-body dosimetry in healthy individuals.
Methods
Seven healthy adults (4 men, 3 women, ages 40.1 ± 4.6 years) completed [
18
F]FNDP brain PET on two occasions within a period of 14 days in a test–retest study design. [
18
F]FNDP regional total distribution volume (V
T
) values were derived from modeling time-activity data with a metabolite-corrected arterial input function. Test–retest variability, mean absolute deviation, and intraclass correlation coefficient (ICC) were investigated. Six other healthy adults (3 men, 3 women, ages 46.0 ± 7.0 years) underwent [
18
F]FNDP PET/CT for whole-body dosimetry, which was acquired over 4.5 h, starting immediately after radiotracer administration. Organ-absorbed doses and the effective dose were then estimated.
Results
The mean test–retest difference in regional V
T
(ΔV
T
) was 0.82 ± 5.17%. The mean absolute difference in regional V
T
was 4.01 ± 3.33%. The ICC across different brain regions ranged from 0.92 to 0.99. The organs with the greatest radiation-absorbed doses included the gallbladder (0.081 ± 0.024 mSv/MBq), followed by liver (0.077 ± 0.018 mSv/MBq) and kidneys (0.063 ± 0.006 mSv/MBq). The effective dose was 0.020 ± 0.003 mSv/MBq.
Conclusion
These data support a favorable test–retest repeatability of [
18
F]FNDP brain PET regional V
T
. The radiation dose to humans from each [
18
F]FNDP PET scan is similar to that of other
18
F-based PET radiotracers.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37458759</pmid><doi>10.1007/s00259-023-06331-z</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6753-3010</orcidid></addata></record> |
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| identifier | ISSN: 1619-7070 |
| ispartof | European journal of nuclear medicine and molecular imaging, 2023-10, Vol.50 (12), p.3659-3665 |
| issn | 1619-7070 1619-7089 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2839246864 |
| source | SpringerNature Journals |
| subjects | Adults Brain Cardiology Correlation coefficients Dosimeters Dosimetry Epoxide hydrolase Fatty acids Fluorine isotopes Gallbladder Homeostasis Imaging Medical imaging Medicine Medicine & Public Health Men Metabolites Neuroimaging Nuclear Medicine Oncology Original Article Orthopedics Polyunsaturated fatty acids Positron emission Positron emission tomography Radiation Radiation dosage Radioactive tracers Radiology Reproducibility Staphylococcal enterotoxin H Women |
| title | [18F]FNDP PET neuroimaging test–retest repeatability and whole-body dosimetry in humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-08T00%3A27%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=%5B18F%5DFNDP%20PET%20neuroimaging%20test%E2%80%93retest%20repeatability%20and%20whole-body%20dosimetry%20in%20humans&rft.jtitle=European%20journal%20of%20nuclear%20medicine%20and%20molecular%20imaging&rft.au=Du,%20Yong&rft.date=2023-10-01&rft.volume=50&rft.issue=12&rft.spage=3659&rft.epage=3665&rft.pages=3659-3665&rft.issn=1619-7070&rft.eissn=1619-7089&rft_id=info:doi/10.1007/s00259-023-06331-z&rft_dat=%3Cproquest_cross%3E2839246864%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2871973783&rft_id=info:pmid/37458759&rfr_iscdi=true |