Association of serum lipids and abnormal lipid score with cancer risk: a population-based prospective study
Background Serum lipid levels are associated with cancer risk. However, there still have uncertainties about the single and combined effects of low lipid levels on cancer risk. Methods A prospective cohort study of 33,773 adults in Shanghai between 2016 and 2017 was conducted. Total cholesterol (TC)...
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| Veröffentlicht in: | Journal of endocrinological investigation 2024-02, Vol.47 (2), p.367-376 |
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| creator | Xie, Y. Jiang, Y. Wu, Y. Su, X. Zhu, D. Gao, P. Yuan, H. Xiang, Y. Wang, J. Zhao, Q. Xu, K. Zhang, T. Man, Q. Chen, X. Zhao, G. Jiang, Y. Suo, C. |
| description | Background
Serum lipid levels are associated with cancer risk. However, there still have uncertainties about the single and combined effects of low lipid levels on cancer risk.
Methods
A prospective cohort study of 33,773 adults in Shanghai between 2016 and 2017 was conducted. Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were measured. Cox proportional hazard models were used to assess the association of single and combined lipids with overall, lung, colon, rectal, thyroid gland, stomach, and female breast cancers. The effect of the combination of abnormal lipid score and lifestyle on cancer was also estimated.
Results
A total of 926 incident cancer cases were identified. In the RCS analysis, hazard ratios (HRs) of overall cancer for individuals with TC |
| doi_str_mv | 10.1007/s40618-023-02153-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2839246852</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2839246852</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-8c5e13b6c61a652600fbafeba175f9b5559a2c2e8410ab2b4b48128d0c67c67e3</originalsourceid><addsrcrecordid>eNp9kU1PFzEQxhsjEUS_gAfTxAuX1b5st11uhIiakHiBc9N2Z7Gwu106u_7Dt6ewoMYDSSedtL95OtOHkA-cfeaM6S9Ys4abiglZgitZ7V6RA64Fq4w0zet_8n3yFvGaMaml0W_IvtS1Mq1kB-TmBDGF6JaYJpp6ipDXkQ5xjh1SN3XU-Snl0Q3bGcWQMtBdXH7R4KYAmeaIN8fU0TnN6_CoU3mH0NE5J5whLPE3UFzW7u4d2evdgPD-aT8kl2dfL06_V-c_v_04PTmvgtRqqUxQwKVvQsNdo0TDWO9dD95xrfrWK6VaJ4IAU3PmvPC1rw0XpmOh0WWBPCRHm27p4HYFXOwYMcAwuAnSilYY2Yq6MUoU9NN_6HVa81S6s6IViulaGFYosVGhjIQZejvnOLp8ZzmzD1bYzQpbrLCPVthdKfr4JL36Ebo_Jc9_XwC5AViupivIf99-QfYeTfuVkA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2925074280</pqid></control><display><type>article</type><title>Association of serum lipids and abnormal lipid score with cancer risk: a population-based prospective study</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Xie, Y. ; Jiang, Y. ; Wu, Y. ; Su, X. ; Zhu, D. ; Gao, P. ; Yuan, H. ; Xiang, Y. ; Wang, J. ; Zhao, Q. ; Xu, K. ; Zhang, T. ; Man, Q. ; Chen, X. ; Zhao, G. ; Jiang, Y. ; Suo, C.</creator><creatorcontrib>Xie, Y. ; Jiang, Y. ; Wu, Y. ; Su, X. ; Zhu, D. ; Gao, P. ; Yuan, H. ; Xiang, Y. ; Wang, J. ; Zhao, Q. ; Xu, K. ; Zhang, T. ; Man, Q. ; Chen, X. ; Zhao, G. ; Jiang, Y. ; Suo, C.</creatorcontrib><description>Background
Serum lipid levels are associated with cancer risk. However, there still have uncertainties about the single and combined effects of low lipid levels on cancer risk.
Methods
A prospective cohort study of 33,773 adults in Shanghai between 2016 and 2017 was conducted. Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were measured. Cox proportional hazard models were used to assess the association of single and combined lipids with overall, lung, colon, rectal, thyroid gland, stomach, and female breast cancers. The effect of the combination of abnormal lipid score and lifestyle on cancer was also estimated.
Results
A total of 926 incident cancer cases were identified. In the RCS analysis, hazard ratios (HRs) of overall cancer for individuals with TC < 5.18 mmol/L or with LDL-C < 3.40 mmol/L were higher. Low TC was associated with higher colorectal cancer risk (HR [95% CI] = 1.76 [1.09–2.84]) and low HDL-C increased thyroid cancer risk by 90%. Abnormal lipid score was linearly and positively associated with cancer risk, and smokers with high abnormal lipid scores had a higher cancer risk, compared to non-smokers with low abnormal lipid scores (
P
< 0.05).
Conclusions
Low TC levels were associated with an increased risk of overall and colorectal cancer. More attention should be paid to participants with high abnormal lipid scores and unhealthy lifestyles who may have a higher risk of developing cancer. Determining the specific and comprehensive lipid combinations that affect tumorigenesis remains a valuable challenge.</description><identifier>ISSN: 1720-8386</identifier><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-023-02153-w</identifier><identifier>PMID: 37458930</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; China - epidemiology ; Cholesterol ; Cholesterol, HDL ; Cholesterol, LDL ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms ; Endocrinology ; Female ; High density lipoprotein ; Humans ; Internal Medicine ; Lipids ; Low density lipoprotein ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Original Article ; Population studies ; Prospective Studies ; Risk Factors ; Serum lipids ; Thyroid cancer ; Thyroid gland ; Triglycerides ; Tumorigenesis</subject><ispartof>Journal of endocrinological investigation, 2024-02, Vol.47 (2), p.367-376</ispartof><rights>The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE) 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-8c5e13b6c61a652600fbafeba175f9b5559a2c2e8410ab2b4b48128d0c67c67e3</citedby><cites>FETCH-LOGICAL-c375t-8c5e13b6c61a652600fbafeba175f9b5559a2c2e8410ab2b4b48128d0c67c67e3</cites><orcidid>0000-0002-5274-4584</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40618-023-02153-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40618-023-02153-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37458930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xie, Y.</creatorcontrib><creatorcontrib>Jiang, Y.</creatorcontrib><creatorcontrib>Wu, Y.</creatorcontrib><creatorcontrib>Su, X.</creatorcontrib><creatorcontrib>Zhu, D.</creatorcontrib><creatorcontrib>Gao, P.</creatorcontrib><creatorcontrib>Yuan, H.</creatorcontrib><creatorcontrib>Xiang, Y.</creatorcontrib><creatorcontrib>Wang, J.</creatorcontrib><creatorcontrib>Zhao, Q.</creatorcontrib><creatorcontrib>Xu, K.</creatorcontrib><creatorcontrib>Zhang, T.</creatorcontrib><creatorcontrib>Man, Q.</creatorcontrib><creatorcontrib>Chen, X.</creatorcontrib><creatorcontrib>Zhao, G.</creatorcontrib><creatorcontrib>Jiang, Y.</creatorcontrib><creatorcontrib>Suo, C.</creatorcontrib><title>Association of serum lipids and abnormal lipid score with cancer risk: a population-based prospective study</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Background
Serum lipid levels are associated with cancer risk. However, there still have uncertainties about the single and combined effects of low lipid levels on cancer risk.
Methods
A prospective cohort study of 33,773 adults in Shanghai between 2016 and 2017 was conducted. Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were measured. Cox proportional hazard models were used to assess the association of single and combined lipids with overall, lung, colon, rectal, thyroid gland, stomach, and female breast cancers. The effect of the combination of abnormal lipid score and lifestyle on cancer was also estimated.
Results
A total of 926 incident cancer cases were identified. In the RCS analysis, hazard ratios (HRs) of overall cancer for individuals with TC < 5.18 mmol/L or with LDL-C < 3.40 mmol/L were higher. Low TC was associated with higher colorectal cancer risk (HR [95% CI] = 1.76 [1.09–2.84]) and low HDL-C increased thyroid cancer risk by 90%. Abnormal lipid score was linearly and positively associated with cancer risk, and smokers with high abnormal lipid scores had a higher cancer risk, compared to non-smokers with low abnormal lipid scores (
P
< 0.05).
Conclusions
Low TC levels were associated with an increased risk of overall and colorectal cancer. More attention should be paid to participants with high abnormal lipid scores and unhealthy lifestyles who may have a higher risk of developing cancer. Determining the specific and comprehensive lipid combinations that affect tumorigenesis remains a valuable challenge.</description><subject>Adult</subject><subject>China - epidemiology</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL</subject><subject>Cholesterol, LDL</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms</subject><subject>Endocrinology</subject><subject>Female</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Original Article</subject><subject>Population studies</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Serum lipids</subject><subject>Thyroid cancer</subject><subject>Thyroid gland</subject><subject>Triglycerides</subject><subject>Tumorigenesis</subject><issn>1720-8386</issn><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1PFzEQxhsjEUS_gAfTxAuX1b5st11uhIiakHiBc9N2Z7Gwu106u_7Dt6ewoMYDSSedtL95OtOHkA-cfeaM6S9Ys4abiglZgitZ7V6RA64Fq4w0zet_8n3yFvGaMaml0W_IvtS1Mq1kB-TmBDGF6JaYJpp6ipDXkQ5xjh1SN3XU-Snl0Q3bGcWQMtBdXH7R4KYAmeaIN8fU0TnN6_CoU3mH0NE5J5whLPE3UFzW7u4d2evdgPD-aT8kl2dfL06_V-c_v_04PTmvgtRqqUxQwKVvQsNdo0TDWO9dD95xrfrWK6VaJ4IAU3PmvPC1rw0XpmOh0WWBPCRHm27p4HYFXOwYMcAwuAnSilYY2Yq6MUoU9NN_6HVa81S6s6IViulaGFYosVGhjIQZejvnOLp8ZzmzD1bYzQpbrLCPVthdKfr4JL36Ebo_Jc9_XwC5AViupivIf99-QfYeTfuVkA</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Xie, Y.</creator><creator>Jiang, Y.</creator><creator>Wu, Y.</creator><creator>Su, X.</creator><creator>Zhu, D.</creator><creator>Gao, P.</creator><creator>Yuan, H.</creator><creator>Xiang, Y.</creator><creator>Wang, J.</creator><creator>Zhao, Q.</creator><creator>Xu, K.</creator><creator>Zhang, T.</creator><creator>Man, Q.</creator><creator>Chen, X.</creator><creator>Zhao, G.</creator><creator>Jiang, Y.</creator><creator>Suo, C.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5274-4584</orcidid></search><sort><creationdate>20240201</creationdate><title>Association of serum lipids and abnormal lipid score with cancer risk: a population-based prospective study</title><author>Xie, Y. ; Jiang, Y. ; Wu, Y. ; Su, X. ; Zhu, D. ; Gao, P. ; Yuan, H. ; Xiang, Y. ; Wang, J. ; Zhao, Q. ; Xu, K. ; Zhang, T. ; Man, Q. ; Chen, X. ; Zhao, G. ; Jiang, Y. ; Suo, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-8c5e13b6c61a652600fbafeba175f9b5559a2c2e8410ab2b4b48128d0c67c67e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>China - epidemiology</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL</topic><topic>Cholesterol, LDL</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms</topic><topic>Endocrinology</topic><topic>Female</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lipids</topic><topic>Low density lipoprotein</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Original Article</topic><topic>Population studies</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Serum lipids</topic><topic>Thyroid cancer</topic><topic>Thyroid gland</topic><topic>Triglycerides</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Y.</creatorcontrib><creatorcontrib>Jiang, Y.</creatorcontrib><creatorcontrib>Wu, Y.</creatorcontrib><creatorcontrib>Su, X.</creatorcontrib><creatorcontrib>Zhu, D.</creatorcontrib><creatorcontrib>Gao, P.</creatorcontrib><creatorcontrib>Yuan, H.</creatorcontrib><creatorcontrib>Xiang, Y.</creatorcontrib><creatorcontrib>Wang, J.</creatorcontrib><creatorcontrib>Zhao, Q.</creatorcontrib><creatorcontrib>Xu, K.</creatorcontrib><creatorcontrib>Zhang, T.</creatorcontrib><creatorcontrib>Man, Q.</creatorcontrib><creatorcontrib>Chen, X.</creatorcontrib><creatorcontrib>Zhao, G.</creatorcontrib><creatorcontrib>Jiang, Y.</creatorcontrib><creatorcontrib>Suo, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Y.</au><au>Jiang, Y.</au><au>Wu, Y.</au><au>Su, X.</au><au>Zhu, D.</au><au>Gao, P.</au><au>Yuan, H.</au><au>Xiang, Y.</au><au>Wang, J.</au><au>Zhao, Q.</au><au>Xu, K.</au><au>Zhang, T.</au><au>Man, Q.</au><au>Chen, X.</au><au>Zhao, G.</au><au>Jiang, Y.</au><au>Suo, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of serum lipids and abnormal lipid score with cancer risk: a population-based prospective study</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>47</volume><issue>2</issue><spage>367</spage><epage>376</epage><pages>367-376</pages><issn>1720-8386</issn><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Background
Serum lipid levels are associated with cancer risk. However, there still have uncertainties about the single and combined effects of low lipid levels on cancer risk.
Methods
A prospective cohort study of 33,773 adults in Shanghai between 2016 and 2017 was conducted. Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were measured. Cox proportional hazard models were used to assess the association of single and combined lipids with overall, lung, colon, rectal, thyroid gland, stomach, and female breast cancers. The effect of the combination of abnormal lipid score and lifestyle on cancer was also estimated.
Results
A total of 926 incident cancer cases were identified. In the RCS analysis, hazard ratios (HRs) of overall cancer for individuals with TC < 5.18 mmol/L or with LDL-C < 3.40 mmol/L were higher. Low TC was associated with higher colorectal cancer risk (HR [95% CI] = 1.76 [1.09–2.84]) and low HDL-C increased thyroid cancer risk by 90%. Abnormal lipid score was linearly and positively associated with cancer risk, and smokers with high abnormal lipid scores had a higher cancer risk, compared to non-smokers with low abnormal lipid scores (
P
< 0.05).
Conclusions
Low TC levels were associated with an increased risk of overall and colorectal cancer. More attention should be paid to participants with high abnormal lipid scores and unhealthy lifestyles who may have a higher risk of developing cancer. Determining the specific and comprehensive lipid combinations that affect tumorigenesis remains a valuable challenge.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>37458930</pmid><doi>10.1007/s40618-023-02153-w</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5274-4584</orcidid></addata></record> |
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| subjects | Adult China - epidemiology Cholesterol Cholesterol, HDL Cholesterol, LDL Colorectal cancer Colorectal carcinoma Colorectal Neoplasms Endocrinology Female High density lipoprotein Humans Internal Medicine Lipids Low density lipoprotein Medicine Medicine & Public Health Metabolic Diseases Original Article Population studies Prospective Studies Risk Factors Serum lipids Thyroid cancer Thyroid gland Triglycerides Tumorigenesis |
| title | Association of serum lipids and abnormal lipid score with cancer risk: a population-based prospective study |
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