Dose‐dependent bidirectional pharmacological effects of vinorelbine‐based metronomic combination chemotherapy on tumor growth and metastasis and mechanisms in melanoma mouse model

Background There is evidence that the empirical setting of doses and schedules of antineoplastic agents in metronomic chemotherapy (MC) might lead to undesirable outcomes, such as promoting tumor growth or metastasis at certain low doses. However, details about the dose effect of antineoplastic agen...

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Veröffentlicht in:	Fundamental & clinical pharmacology 2024-02, Vol.38 (1), p.99-112
Hauptverfasser:	Liu, Hua, Zheng, Qiaowei, Li, Min, Kou, Jianrong, Wei, Junsong, Feng, Weiyi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Angiogenesis Animals Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic drugs Apoptosis bidirectional effect Carcinoma, Non-Small-Cell Lung - drug therapy Cell growth Cell migration Cell proliferation Chemotherapy Cisplatin Cisplatin - pharmacology Drug Therapy, Combination Flow cytometry Immunofluorescence Immunohistochemistry Low concentrations Lung Neoplasms - drug therapy mechanism Melanoma Melanoma - drug therapy Metastases Metastasis metronomic combination chemotherapy Mice Schedules Suppressor cells tumor growth Tumors Vinblastine - pharmacology Vinorelbine Vinorelbine - adverse effects
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