Arylacetonitrilases: Potential Biocatalysts for Green Chemistry
Nitrilases are the enzymes that catalyze the hydrolysis of nitriles to corresponding carboxylic acid and ammonia. They are broadly categorized into aromatic, aliphatic, and arylacetonitrilases based on their substrate specificity. Most of the studies pertaining to these enzymes in the literature hav...
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| Veröffentlicht in: | Applied biochemistry and biotechnology 2024-04, Vol.196 (4), p.1769-1785 |
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| creator | Bhalla, Tek Chand Thakur, Neerja Kumar, Vijay |
| description | Nitrilases are the enzymes that catalyze the hydrolysis of nitriles to corresponding carboxylic acid and ammonia. They are broadly categorized into aromatic, aliphatic, and arylacetonitrilases based on their substrate specificity. Most of the studies pertaining to these enzymes in the literature have focused on aromatic and aliphatic nitrilases. However, arylacetonitrilases have attracted the attention of academia and industry in the last several years due to their aryl specificity and enantioselectivity. They have emerged as interesting biocatalytic tools in green chemistry to synthesize useful aryl acids such as mandelic acid and derivatives of phenylacetic acid. The aim of the present review is to collate information on the arylacetonitrilases and their catalytic properties including enantioselectivity and potential applications in organic synthesis. |
| doi_str_mv | 10.1007/s12010-023-04643-2 |
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They are broadly categorized into aromatic, aliphatic, and arylacetonitrilases based on their substrate specificity. Most of the studies pertaining to these enzymes in the literature have focused on aromatic and aliphatic nitrilases. However, arylacetonitrilases have attracted the attention of academia and industry in the last several years due to their aryl specificity and enantioselectivity. They have emerged as interesting biocatalytic tools in green chemistry to synthesize useful aryl acids such as mandelic acid and derivatives of phenylacetic acid. 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| subjects | Acids Aliphatic compounds Aminohydrolases - chemistry Aminohydrolases - metabolism Ammonia Aromatic compounds Bacteria Biocatalysis Biocatalysts Biochemistry Biotechnology Carbon Carboxylic acids Chemical synthesis Chemistry Chemistry and Materials Science Cosmetics Enantiomers Enzymes Green chemistry Green Chemistry Technology Mandelic Acids - chemistry Mandelic Acids - metabolism Nitriles Nitriles - chemistry Nitriles - metabolism Nitrogen Phenylacetic acid Review Stereoisomerism Substrate Specificity Substrates |
| title | Arylacetonitrilases: Potential Biocatalysts for Green Chemistry |
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