Pre-existing sarcopenia and swallowing outcomes in acute stroke patients
This study aimed to investigate the associations of pre-existing sarcopenia with swallowing function, oral intake level, and aspiration pneumonia in patients with acute stroke. This observational study included patients (≥60 years of age) with acute ischemic stroke or intracerebral hemorrhage within...
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| Veröffentlicht in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2023-08, Vol.42 (8), p.1454-1461 |
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| creator | Fukuma, Kazuki Kamada, Masatoshi Yamamoto, Kazuya Yokota, Chiaki Abe, Soichiro Nakazawa, Shinsaku Tanaka, Tomotaka Chichikawa, Takuro Nakaoku, Yuriko Nishimura, Kunihiro Koga, Masatoshi Takaya, Shigetoshi Sugimoto, Ken Nishioka, Shinta Wakabayashi, Hidetaka Fujishima, Ichiro Ihara, Masafumi |
| description | This study aimed to investigate the associations of pre-existing sarcopenia with swallowing function, oral intake level, and aspiration pneumonia in patients with acute stroke.
This observational study included patients (≥60 years of age) with acute ischemic stroke or intracerebral hemorrhage within 7 days of onset who were screened for sarcopenia, malnutrition, and swallowing difficulties in a stroke-care unit within 48 h of admission. Sarcopenia was defined by the Asian Working Group on Sarcopenia 2019 as having a low calf circumference, handgrip strength, and appendicular muscle mass index. The primary outcome was impaired oral intake (functional oral intake scale |
| doi_str_mv | 10.1016/j.clnu.2023.06.012 |
| format | Article |
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This observational study included patients (≥60 years of age) with acute ischemic stroke or intracerebral hemorrhage within 7 days of onset who were screened for sarcopenia, malnutrition, and swallowing difficulties in a stroke-care unit within 48 h of admission. Sarcopenia was defined by the Asian Working Group on Sarcopenia 2019 as having a low calf circumference, handgrip strength, and appendicular muscle mass index. The primary outcome was impaired oral intake (functional oral intake scale <5 points) at 3, 7, and 14 days after admission, and the secondary outcome was aspiration pneumonia during hospitalization.
We enrolled 350 patients (median age of 77 years; 63% males) who underwent the aforementioned screening. Sarcopenia was diagnosed in 34% of patients, and malnutrition was found in 66% of patients with sarcopenia. When compared with the comparison group (defined as patients with either or both normal calf circumference and handgrip strength), the sarcopenia group had significantly lower tongue pressure and a higher prevalence of dysphagia. Sarcopenia was associated with functional oral intake scale <5 at 7 days (adjusted odds ratio [OR], 4.72; 95% confidence interval [CI], 1.91–11.71); p = 0.002) and 14 days (adjusted OR, 3.93; 95% CI, 1.47–10.53; p = 0.006) and with aspiration pneumonia during hospitalization (adjusted OR, 6.12; 95% CI, 1.63–22.94; p = 0.007).
Acute stroke patients with sarcopenia may have weakness of the swallowing-related muscles which may lead to impaired oral intake and aspiration pneumonia.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2023.06.012</identifier><identifier>PMID: 37451157</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acute stroke ; Aspiration pneumonia ; Dysphagia ; Energy intake ; Malnutrition ; Sarcopenia</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2023-08, Vol.42 (8), p.1454-1461</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-73e28b535ca9f1b0b16c9401b4e94872d9ff23f933ac4653347546d6d3059dad3</citedby><cites>FETCH-LOGICAL-c356t-73e28b535ca9f1b0b16c9401b4e94872d9ff23f933ac4653347546d6d3059dad3</cites><orcidid>0000-0002-7102-4048 ; 0000-0002-6726-8605 ; 0000-0001-6516-5998 ; 0000-0001-8117-8916 ; 0000-0002-6023-236X ; 0000-0001-9528-8702 ; 0000-0002-0364-0818 ; 0000-0002-2529-3458</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clnu.2023.06.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37451157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukuma, Kazuki</creatorcontrib><creatorcontrib>Kamada, Masatoshi</creatorcontrib><creatorcontrib>Yamamoto, Kazuya</creatorcontrib><creatorcontrib>Yokota, Chiaki</creatorcontrib><creatorcontrib>Abe, Soichiro</creatorcontrib><creatorcontrib>Nakazawa, Shinsaku</creatorcontrib><creatorcontrib>Tanaka, Tomotaka</creatorcontrib><creatorcontrib>Chichikawa, Takuro</creatorcontrib><creatorcontrib>Nakaoku, Yuriko</creatorcontrib><creatorcontrib>Nishimura, Kunihiro</creatorcontrib><creatorcontrib>Koga, Masatoshi</creatorcontrib><creatorcontrib>Takaya, Shigetoshi</creatorcontrib><creatorcontrib>Sugimoto, Ken</creatorcontrib><creatorcontrib>Nishioka, Shinta</creatorcontrib><creatorcontrib>Wakabayashi, Hidetaka</creatorcontrib><creatorcontrib>Fujishima, Ichiro</creatorcontrib><creatorcontrib>Ihara, Masafumi</creatorcontrib><title>Pre-existing sarcopenia and swallowing outcomes in acute stroke patients</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>This study aimed to investigate the associations of pre-existing sarcopenia with swallowing function, oral intake level, and aspiration pneumonia in patients with acute stroke.
This observational study included patients (≥60 years of age) with acute ischemic stroke or intracerebral hemorrhage within 7 days of onset who were screened for sarcopenia, malnutrition, and swallowing difficulties in a stroke-care unit within 48 h of admission. Sarcopenia was defined by the Asian Working Group on Sarcopenia 2019 as having a low calf circumference, handgrip strength, and appendicular muscle mass index. The primary outcome was impaired oral intake (functional oral intake scale <5 points) at 3, 7, and 14 days after admission, and the secondary outcome was aspiration pneumonia during hospitalization.
We enrolled 350 patients (median age of 77 years; 63% males) who underwent the aforementioned screening. Sarcopenia was diagnosed in 34% of patients, and malnutrition was found in 66% of patients with sarcopenia. When compared with the comparison group (defined as patients with either or both normal calf circumference and handgrip strength), the sarcopenia group had significantly lower tongue pressure and a higher prevalence of dysphagia. Sarcopenia was associated with functional oral intake scale <5 at 7 days (adjusted odds ratio [OR], 4.72; 95% confidence interval [CI], 1.91–11.71); p = 0.002) and 14 days (adjusted OR, 3.93; 95% CI, 1.47–10.53; p = 0.006) and with aspiration pneumonia during hospitalization (adjusted OR, 6.12; 95% CI, 1.63–22.94; p = 0.007).
Acute stroke patients with sarcopenia may have weakness of the swallowing-related muscles which may lead to impaired oral intake and aspiration pneumonia.</description><subject>Acute stroke</subject><subject>Aspiration pneumonia</subject><subject>Dysphagia</subject><subject>Energy intake</subject><subject>Malnutrition</subject><subject>Sarcopenia</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kLtOxDAQRS0EYpeFH6BAKWkSbE_sJBINQrwkJCigthx7grxk48V2ePw9WS1QUk1xz73SHEKOGS0YZfJsWZh-GAtOORRUFpTxHTJnAnjOmhp2yZxyyXIhWTkjBzEuKaUCqnqfzKAqBWOimpPbx4A5frqY3PCSRR2MX-PgdKYHm8UP3ff-Y5P4MRm_wpi5IdNmTJjFFPwrZmudHA4pHpK9TvcRj37ugjxfXz1d3ub3Dzd3lxf3uQEhU14B8roVIIxuOtbSlknTlJS1JTZlXXHbdB2HrgHQppQCoKxEKa20QEVjtYUFOd3uroN_GzEmtXLRYN_rAf0YFa-h5oJD1Uwo36Im-BgDdmod3EqHL8Wo2hhUS7UxqDYGFZVqMjiVTn72x3aF9q_yq2wCzrcATl--OwwqmsmAQesCmqSsd__tfwMuWYHu</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Fukuma, Kazuki</creator><creator>Kamada, Masatoshi</creator><creator>Yamamoto, Kazuya</creator><creator>Yokota, Chiaki</creator><creator>Abe, Soichiro</creator><creator>Nakazawa, Shinsaku</creator><creator>Tanaka, Tomotaka</creator><creator>Chichikawa, Takuro</creator><creator>Nakaoku, Yuriko</creator><creator>Nishimura, Kunihiro</creator><creator>Koga, Masatoshi</creator><creator>Takaya, Shigetoshi</creator><creator>Sugimoto, Ken</creator><creator>Nishioka, Shinta</creator><creator>Wakabayashi, Hidetaka</creator><creator>Fujishima, Ichiro</creator><creator>Ihara, Masafumi</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7102-4048</orcidid><orcidid>https://orcid.org/0000-0002-6726-8605</orcidid><orcidid>https://orcid.org/0000-0001-6516-5998</orcidid><orcidid>https://orcid.org/0000-0001-8117-8916</orcidid><orcidid>https://orcid.org/0000-0002-6023-236X</orcidid><orcidid>https://orcid.org/0000-0001-9528-8702</orcidid><orcidid>https://orcid.org/0000-0002-0364-0818</orcidid><orcidid>https://orcid.org/0000-0002-2529-3458</orcidid></search><sort><creationdate>202308</creationdate><title>Pre-existing sarcopenia and swallowing outcomes in acute stroke patients</title><author>Fukuma, Kazuki ; Kamada, Masatoshi ; Yamamoto, Kazuya ; Yokota, Chiaki ; Abe, Soichiro ; Nakazawa, Shinsaku ; Tanaka, Tomotaka ; Chichikawa, Takuro ; Nakaoku, Yuriko ; Nishimura, Kunihiro ; Koga, Masatoshi ; Takaya, Shigetoshi ; Sugimoto, Ken ; Nishioka, Shinta ; Wakabayashi, Hidetaka ; Fujishima, Ichiro ; Ihara, Masafumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-73e28b535ca9f1b0b16c9401b4e94872d9ff23f933ac4653347546d6d3059dad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute stroke</topic><topic>Aspiration pneumonia</topic><topic>Dysphagia</topic><topic>Energy intake</topic><topic>Malnutrition</topic><topic>Sarcopenia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukuma, Kazuki</creatorcontrib><creatorcontrib>Kamada, Masatoshi</creatorcontrib><creatorcontrib>Yamamoto, Kazuya</creatorcontrib><creatorcontrib>Yokota, Chiaki</creatorcontrib><creatorcontrib>Abe, Soichiro</creatorcontrib><creatorcontrib>Nakazawa, Shinsaku</creatorcontrib><creatorcontrib>Tanaka, Tomotaka</creatorcontrib><creatorcontrib>Chichikawa, Takuro</creatorcontrib><creatorcontrib>Nakaoku, Yuriko</creatorcontrib><creatorcontrib>Nishimura, Kunihiro</creatorcontrib><creatorcontrib>Koga, Masatoshi</creatorcontrib><creatorcontrib>Takaya, Shigetoshi</creatorcontrib><creatorcontrib>Sugimoto, Ken</creatorcontrib><creatorcontrib>Nishioka, Shinta</creatorcontrib><creatorcontrib>Wakabayashi, Hidetaka</creatorcontrib><creatorcontrib>Fujishima, Ichiro</creatorcontrib><creatorcontrib>Ihara, Masafumi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukuma, Kazuki</au><au>Kamada, Masatoshi</au><au>Yamamoto, Kazuya</au><au>Yokota, Chiaki</au><au>Abe, Soichiro</au><au>Nakazawa, Shinsaku</au><au>Tanaka, Tomotaka</au><au>Chichikawa, Takuro</au><au>Nakaoku, Yuriko</au><au>Nishimura, Kunihiro</au><au>Koga, Masatoshi</au><au>Takaya, Shigetoshi</au><au>Sugimoto, Ken</au><au>Nishioka, Shinta</au><au>Wakabayashi, Hidetaka</au><au>Fujishima, Ichiro</au><au>Ihara, Masafumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pre-existing sarcopenia and swallowing outcomes in acute stroke patients</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2023-08</date><risdate>2023</risdate><volume>42</volume><issue>8</issue><spage>1454</spage><epage>1461</epage><pages>1454-1461</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><abstract>This study aimed to investigate the associations of pre-existing sarcopenia with swallowing function, oral intake level, and aspiration pneumonia in patients with acute stroke.
This observational study included patients (≥60 years of age) with acute ischemic stroke or intracerebral hemorrhage within 7 days of onset who were screened for sarcopenia, malnutrition, and swallowing difficulties in a stroke-care unit within 48 h of admission. Sarcopenia was defined by the Asian Working Group on Sarcopenia 2019 as having a low calf circumference, handgrip strength, and appendicular muscle mass index. The primary outcome was impaired oral intake (functional oral intake scale <5 points) at 3, 7, and 14 days after admission, and the secondary outcome was aspiration pneumonia during hospitalization.
We enrolled 350 patients (median age of 77 years; 63% males) who underwent the aforementioned screening. Sarcopenia was diagnosed in 34% of patients, and malnutrition was found in 66% of patients with sarcopenia. When compared with the comparison group (defined as patients with either or both normal calf circumference and handgrip strength), the sarcopenia group had significantly lower tongue pressure and a higher prevalence of dysphagia. Sarcopenia was associated with functional oral intake scale <5 at 7 days (adjusted odds ratio [OR], 4.72; 95% confidence interval [CI], 1.91–11.71); p = 0.002) and 14 days (adjusted OR, 3.93; 95% CI, 1.47–10.53; p = 0.006) and with aspiration pneumonia during hospitalization (adjusted OR, 6.12; 95% CI, 1.63–22.94; p = 0.007).
Acute stroke patients with sarcopenia may have weakness of the swallowing-related muscles which may lead to impaired oral intake and aspiration pneumonia.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37451157</pmid><doi>10.1016/j.clnu.2023.06.012</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7102-4048</orcidid><orcidid>https://orcid.org/0000-0002-6726-8605</orcidid><orcidid>https://orcid.org/0000-0001-6516-5998</orcidid><orcidid>https://orcid.org/0000-0001-8117-8916</orcidid><orcidid>https://orcid.org/0000-0002-6023-236X</orcidid><orcidid>https://orcid.org/0000-0001-9528-8702</orcidid><orcidid>https://orcid.org/0000-0002-0364-0818</orcidid><orcidid>https://orcid.org/0000-0002-2529-3458</orcidid></addata></record> |
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| identifier | ISSN: 0261-5614 |
| ispartof | Clinical nutrition (Edinburgh, Scotland), 2023-08, Vol.42 (8), p.1454-1461 |
| issn | 0261-5614 1532-1983 |
| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Acute stroke Aspiration pneumonia Dysphagia Energy intake Malnutrition Sarcopenia |
| title | Pre-existing sarcopenia and swallowing outcomes in acute stroke patients |
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