Control of histone demethylation by nuclear-localized α-ketoglutarate dehydrogenase

Methylations on nucleosomal histones play fundamental roles in regulating eukaryotic transcription. Jumonji C domain-containing histone demethylases (JMJs) dynamically control the level of histone methylations. However, how JMJ activity is generally regulated is unknown. We found that the tricarboxy...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2023-07, Vol.381 (6654), p.eadf8822-eadf8822
Hauptverfasser:	Huang, Fei, Luo, Xiao, Ou, Yang, Gao, Zhaoxu, Tang, Qiming, Chu, Zhenzhen, Zhu, Xinguang, He, Yuehui
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Animals Anthocyanins Arabidopsis Biochemical analysis Chromatin Decarboxylation Dehydrogenase Dehydrogenases Demethylation DNA methylation DNA sequencing Enzymes Eukaryotes Flowering Fluoroscopic imaging Gene expression Genes Genomes Histones Immunoprecipitation Inhibition Ketoglutaric acid Localization Lysine Mammalian cells Mammals Metabolites Methylation Mitochondria Mutants Nuclei (cytology) Oxidation Oxoglutarate dehydrogenase (lipoamide) Oxygen Protein interaction Proteins Substrates Transcriptomics Tricarboxylic acid cycle
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