Shh–Gli2–Runx2 inhibits vascular calcification

ABSTRACT Background In patients with chronic kidney disease (CKD), vascular calcification (VC) is common and is associated with a higher risk of all-cause mortality. Shh, one ligand for Hedgehog (Hh) signaling, participates in osteogenesis and several cardiovascular diseases. However, it remains unc...

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Veröffentlicht in:	Nephrology, dialysis, transplantation dialysis, transplantation, 2024-01, Vol.39 (2), p.305-316
Hauptverfasser:	Huang, Aoran, Xu, Tianhua, Lu, Xiaomei, Ma, Ling, Ma, Haiying, Yu, Yanqiu, Yao, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Animals Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Hedgehog Proteins - pharmacology Humans Mice Myocytes, Smooth Muscle - metabolism Phosphorus - metabolism Renal Insufficiency, Chronic - pathology Vascular Calcification - etiology Vascular Calcification - metabolism Vascular Calcification - prevention & control
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