Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

Genome-wide association studies (GWASs) are a valuable tool for understanding the biology of complex human traits and diseases, but associated variants rarely point directly to causal genes. In the present study, we introduce a new method, polygenic priority score (PoPS), that learns trait-relevant...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2023-08, Vol.55 (8), p.1267-1276
Hauptverfasser:	Weeks, Elle M., Ulirsch, Jacob C., Cheng, Nathan Y., Trippe, Brian L., Fine, Rebecca S., Miao, Jenkai, Patwardhan, Tejal A., Kanai, Masahiro, Nasser, Joseph, Fulco, Charles P., Tashman, Katherine C., Aguet, Francois, Li, Taibo, Ordovas-Montanes, Jose, Smillie, Christopher S., Biton, Moshe, Shalek, Alex K., Ananthakrishnan, Ashwin N., Xavier, Ramnik J., Regev, Aviv, Gupta, Rajat M., Lage, Kasper, Ardlie, Kristin G., Hirschhorn, Joel N., Lander, Eric S., Engreitz, Jesse M., Finucane, Hilary K.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/43 631/114 631/208 Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Cancer Research Feature selection Gene expression Gene Function Gene loci Genes Genetic Predisposition to Disease - genetics Genome-wide association studies Genome-Wide Association Study - methods Genomes Glomerular filtration rate Human Genetics Humans Loci Methods Multifactorial Inheritance - genetics Nominations Performance evaluation Phenotype Polygenic inheritance Polymorphism, Single Nucleotide - genetics Proteins Quantitative Trait Loci - genetics Thromboembolism Thrombosis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!