Endothelial Insulin Resistance Exacerbates Experimental Periodontitis

Epidemiological studies suggest that the severity of periodontitis is higher in people with diabetes than in healthy individuals. Insulin resistance might play a crucial role in the pathogenesis of multiple diabetic complications and is reportedly induced in the gingiva of rodents with type 2 diabet...

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Veröffentlicht in:	Journal of dental research 2023-09, Vol.102 (10), p.1152-1161
Hauptverfasser:	Zeze, T., Shinjo, T., Sato, K., Nishimura, Y., Imagawa, M., Chen, S., Ahmed, A.-k., Iwashita, M., Yamashita, A., Fukuda, T., Sanui, T., Park, K., King, G.L., Nishimura, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Alveolar bone Bone loss Diabetes Diabetes mellitus (non-insulin dependent) Down-regulation Endothelial cells Epidemiology FOXO1 protein Gingiva Gum disease High fat diet Hyperglycemia Insulin resistance Leukocyte migration Leukocytes Leukocytes (neutrophilic) Lipopolysaccharides Molecular modelling Monocyte chemoattractant protein 1 Pathogenesis Periodontitis Phosphorylation Tumor necrosis factor-α
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