Aura phenomena do not initiate migraine attacks-Findings from neuroimaging
As cortical spreading depolarization (CSD) has been suggested to be the cause of migraine aura and as CSD can activate trigeminal nociceptive neurons in animals, it has been suggested that CSD may be the cause of migraine attacks. This raises the question of how migraine pain is generated in migrain...
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| Veröffentlicht in: | Headache 2023-09, Vol.63 (8), p.1040-1044 |
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| creator | Mehnert, Jan Fischer-Schulte, Laura May, Arne |
| description | As cortical spreading depolarization (CSD) has been suggested to be the cause of migraine aura and as CSD can activate trigeminal nociceptive neurons in animals, it has been suggested that CSD may be the cause of migraine attacks. This raises the question of how migraine pain is generated in migraine attacks without aura and has led to the hypothesis that CSD may also occur in subcortical regions in the form of "silent" CSDs, and accordingly "silent auras".
In this case study, we provide evidence for common neuronal alterations preceding headache attacks with and without aura in a male patient with migraine, who underwent daily event-correlated functional magnetic resonance imaging of trigeminal nociception for a period of 30 days. During these days the man experienced migraine attacks with and without aura.
Comparing the preictal phases between both attack types revealed a common hyperactivation of the hypothalamus (p |
| doi_str_mv | 10.1111/head.14597 |
| format | Article |
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In this case study, we provide evidence for common neuronal alterations preceding headache attacks with and without aura in a male patient with migraine, who underwent daily event-correlated functional magnetic resonance imaging of trigeminal nociception for a period of 30 days. During these days the man experienced migraine attacks with and without aura.
Comparing the preictal phases between both attack types revealed a common hyperactivation of the hypothalamus (p < 0.01), which was already present 2 days before the actual attack.
The time frame of the central pathophysiological orchestration of migraine attacks, irrelevant of the presence of later aura, strongly suggests that the aura is an epiphenomenon that is unrelated and does not initiate headache attacks.</description><identifier>ISSN: 0017-8748</identifier><identifier>ISSN: 1526-4610</identifier><identifier>EISSN: 1526-4610</identifier><identifier>DOI: 10.1111/head.14597</identifier><identifier>PMID: 37449553</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Cortical Spreading Depression - physiology ; Depolarization ; Epilepsy ; Functional magnetic resonance imaging ; Headache ; Hypothalamus ; Magnetic resonance imaging ; Male ; Medical imaging ; Migraine ; Migraine Disorders - diagnostic imaging ; Migraine with Aura - diagnostic imaging ; Neuroimaging ; Pain perception ; Spreading depression</subject><ispartof>Headache, 2023-09, Vol.63 (8), p.1040-1044</ispartof><rights>2023 The Authors. Headache: The Journal of Head and Face Pain published by Wiley Periodicals LLC on behalf of American Headache Society.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-dd58f4a58ff5552f465cb5b82202554c36cbb7a68083316120e8f40b208d623f3</citedby><cites>FETCH-LOGICAL-c351t-dd58f4a58ff5552f465cb5b82202554c36cbb7a68083316120e8f40b208d623f3</cites><orcidid>0000-0002-3499-1506 ; 0000-0001-7088-740X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37449553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehnert, Jan</creatorcontrib><creatorcontrib>Fischer-Schulte, Laura</creatorcontrib><creatorcontrib>May, Arne</creatorcontrib><title>Aura phenomena do not initiate migraine attacks-Findings from neuroimaging</title><title>Headache</title><addtitle>Headache</addtitle><description>As cortical spreading depolarization (CSD) has been suggested to be the cause of migraine aura and as CSD can activate trigeminal nociceptive neurons in animals, it has been suggested that CSD may be the cause of migraine attacks. This raises the question of how migraine pain is generated in migraine attacks without aura and has led to the hypothesis that CSD may also occur in subcortical regions in the form of "silent" CSDs, and accordingly "silent auras".
In this case study, we provide evidence for common neuronal alterations preceding headache attacks with and without aura in a male patient with migraine, who underwent daily event-correlated functional magnetic resonance imaging of trigeminal nociception for a period of 30 days. During these days the man experienced migraine attacks with and without aura.
Comparing the preictal phases between both attack types revealed a common hyperactivation of the hypothalamus (p < 0.01), which was already present 2 days before the actual attack.
The time frame of the central pathophysiological orchestration of migraine attacks, irrelevant of the presence of later aura, strongly suggests that the aura is an epiphenomenon that is unrelated and does not initiate headache attacks.</description><subject>Animals</subject><subject>Cortical Spreading Depression - physiology</subject><subject>Depolarization</subject><subject>Epilepsy</subject><subject>Functional magnetic resonance imaging</subject><subject>Headache</subject><subject>Hypothalamus</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Migraine</subject><subject>Migraine Disorders - diagnostic imaging</subject><subject>Migraine with Aura - diagnostic imaging</subject><subject>Neuroimaging</subject><subject>Pain perception</subject><subject>Spreading depression</subject><issn>0017-8748</issn><issn>1526-4610</issn><issn>1526-4610</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1LAzEQhoMotlYv_gAJeBFha74mmz2WYv2g4EXPS3Y326Z2k5rsHvz3plY9OIcZGB5eZh6ELimZ0lR3a6ObKRVQ5EdoTIHJTEhKjtGYEJpnKhdqhM5i3BBChCzkKRrxXIgCgI_R82wIGu_WxvnOOI0bj53vsXW2t7o3uLOroK0zWPe9rt9jtrCusW4VcRt8h50ZgredXqXVOTpp9Taai585QW-L-9f5Y7Z8eXiaz5ZZzYH2WdOAaoVOrQUA1goJdQWVYowwAFFzWVdVrqUiinMqKSMm8aRiRDWS8ZZP0M0hdxf8x2BiX3Y21ma71c74IZZMccWA0pwl9PofuvFDcOm6REkoVK64TNTtgaqDjzGYttyF9FP4LCkp94bLveHy23CCr34ih6ozzR_6q5R_AY9odTY</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Mehnert, Jan</creator><creator>Fischer-Schulte, Laura</creator><creator>May, Arne</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3499-1506</orcidid><orcidid>https://orcid.org/0000-0001-7088-740X</orcidid></search><sort><creationdate>20230901</creationdate><title>Aura phenomena do not initiate migraine attacks-Findings from neuroimaging</title><author>Mehnert, Jan ; Fischer-Schulte, Laura ; May, Arne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-dd58f4a58ff5552f465cb5b82202554c36cbb7a68083316120e8f40b208d623f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Cortical Spreading Depression - physiology</topic><topic>Depolarization</topic><topic>Epilepsy</topic><topic>Functional magnetic resonance imaging</topic><topic>Headache</topic><topic>Hypothalamus</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Migraine</topic><topic>Migraine Disorders - diagnostic imaging</topic><topic>Migraine with Aura - diagnostic imaging</topic><topic>Neuroimaging</topic><topic>Pain perception</topic><topic>Spreading depression</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehnert, Jan</creatorcontrib><creatorcontrib>Fischer-Schulte, Laura</creatorcontrib><creatorcontrib>May, Arne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Headache</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehnert, Jan</au><au>Fischer-Schulte, Laura</au><au>May, Arne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aura phenomena do not initiate migraine attacks-Findings from neuroimaging</atitle><jtitle>Headache</jtitle><addtitle>Headache</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>63</volume><issue>8</issue><spage>1040</spage><epage>1044</epage><pages>1040-1044</pages><issn>0017-8748</issn><issn>1526-4610</issn><eissn>1526-4610</eissn><abstract>As cortical spreading depolarization (CSD) has been suggested to be the cause of migraine aura and as CSD can activate trigeminal nociceptive neurons in animals, it has been suggested that CSD may be the cause of migraine attacks. This raises the question of how migraine pain is generated in migraine attacks without aura and has led to the hypothesis that CSD may also occur in subcortical regions in the form of "silent" CSDs, and accordingly "silent auras".
In this case study, we provide evidence for common neuronal alterations preceding headache attacks with and without aura in a male patient with migraine, who underwent daily event-correlated functional magnetic resonance imaging of trigeminal nociception for a period of 30 days. During these days the man experienced migraine attacks with and without aura.
Comparing the preictal phases between both attack types revealed a common hyperactivation of the hypothalamus (p < 0.01), which was already present 2 days before the actual attack.
The time frame of the central pathophysiological orchestration of migraine attacks, irrelevant of the presence of later aura, strongly suggests that the aura is an epiphenomenon that is unrelated and does not initiate headache attacks.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37449553</pmid><doi>10.1111/head.14597</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-3499-1506</orcidid><orcidid>https://orcid.org/0000-0001-7088-740X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cortical Spreading Depression - physiology Depolarization Epilepsy Functional magnetic resonance imaging Headache Hypothalamus Magnetic resonance imaging Male Medical imaging Migraine Migraine Disorders - diagnostic imaging Migraine with Aura - diagnostic imaging Neuroimaging Pain perception Spreading depression |
| title | Aura phenomena do not initiate migraine attacks-Findings from neuroimaging |
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