Value of prognostic scoring systems in the era of multimodal therapy for recurrent colorectal liver metastases
Various predictive scoring systems have been developed to estimate outcomes of patients undergoing surgery for colorectal liver metastases (CRLM). However, data regarding their effectiveness in recurrent CRLM (recCRLM) are very limited. Patients who underwent repeat hepatectomy for recCRLM at the Un...
Gespeichert in:
| Veröffentlicht in: | HPB (Oxford, England) England), 2023-11, Vol.25 (11), p.1354-1363 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1363 |
|---|---|
| container_issue | 11 |
| container_start_page | 1354 |
| container_title | HPB (Oxford, England) |
| container_volume | 25 |
| creator | Joechle, Katharina Amygdalos, Iakovos Schmidt, Felix Bednarsch, Jan Chrysos, Alexandros Meister, Franziska A. Czigany, Zoltan Heise, Daniel Berres, Marie-Luise Bruners, Philipp Ulmer, Tom F. Neumann, Ulf P. Lang, Sven A. |
| description | Various predictive scoring systems have been developed to estimate outcomes of patients undergoing surgery for colorectal liver metastases (CRLM). However, data regarding their effectiveness in recurrent CRLM (recCRLM) are very limited.
Patients who underwent repeat hepatectomy for recCRLM at the University Hospital RWTH Aachen, Germany from 2010 to 2021 were included. Nine predictive scoring systems (Fong's, Nordlinger, Nagashima, RAS mutation, Tumor Burden, GAME, CERR, and Glasgow Prognostic score, Basingstoke Index) were evaluated by likelihood ratio (LR) χ2, linear trend (LT) χ2 and Akaike Information Criterion (AIC) for their predictive value regarding overall survival (OS) and recurrence free survival (RFS).
Among 150 patients, median RFS was 9 (2–124) months with a 5-year RFS rate of 10%. Median OS was 39 (4–131) months with a 5-year OS rate of 32%. For RFS and OS, the Nagashima score showed the best prognostic ability (LT χ2 3.00, LR χ2 9.39, AIC 266.66 and LT χ2 2.91, LR χ2 20.91, 290.36).
The Nagashima score showed the best prognostic stratification to predict recurrence as well as survival, and therefore might be considered when evaluating patients with recCRLM for repeat hepatectomy. |
| doi_str_mv | 10.1016/j.hpb.2023.06.016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2836875749</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1365182X23005713</els_id><sourcerecordid>2836875749</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-316095a8a41388cbc2aec32a2790a854e0885eb1b6d591d8362d1a3df8bb6d693</originalsourceid><addsrcrecordid>eNp9kMtKxDAUhoMoOo4-gBvJ0k1rLr2kuJLBGwy4UXEX0vR0JkPbjEk6MG9vyqhLIZDk5_sPnA-hK0pSSmhxu0nX2zplhPGUFGlMjtCMZmWZsLzMjuObF3lCBfs8Q-febwhhsVadojNeZlxQkc_Q8KG6EbBt8dbZ1WB9MBp7bZ0ZVtjvfYDeYzPgsAYMTk1gP3bB9LZR3ZQ6td3j1jrsQI_OwRCwtp2NvxCBzuzA4R6C8vGAv0Anreo8XP7cc_T--PC2eE6Wr08vi_tlonnOQ8JpQapcCZVRLoSuNVOgOVOsrIgSeQZEiBxqWhdNXtFG8II1VPGmFXWMiorP0c1hbtzqawQfZG-8hq5TA9jRSxYrooyWJpQeUO2s9w5auXWmV24vKZGTZrmRUbOcNEtSyJjEzvXP-LHuoflr_HqNwN0BgLjkzoCTXhsYNDRmMiMba_4Z_w2zEY-Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2836875749</pqid></control><display><type>article</type><title>Value of prognostic scoring systems in the era of multimodal therapy for recurrent colorectal liver metastases</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Joechle, Katharina ; Amygdalos, Iakovos ; Schmidt, Felix ; Bednarsch, Jan ; Chrysos, Alexandros ; Meister, Franziska A. ; Czigany, Zoltan ; Heise, Daniel ; Berres, Marie-Luise ; Bruners, Philipp ; Ulmer, Tom F. ; Neumann, Ulf P. ; Lang, Sven A.</creator><creatorcontrib>Joechle, Katharina ; Amygdalos, Iakovos ; Schmidt, Felix ; Bednarsch, Jan ; Chrysos, Alexandros ; Meister, Franziska A. ; Czigany, Zoltan ; Heise, Daniel ; Berres, Marie-Luise ; Bruners, Philipp ; Ulmer, Tom F. ; Neumann, Ulf P. ; Lang, Sven A.</creatorcontrib><description>Various predictive scoring systems have been developed to estimate outcomes of patients undergoing surgery for colorectal liver metastases (CRLM). However, data regarding their effectiveness in recurrent CRLM (recCRLM) are very limited.
Patients who underwent repeat hepatectomy for recCRLM at the University Hospital RWTH Aachen, Germany from 2010 to 2021 were included. Nine predictive scoring systems (Fong's, Nordlinger, Nagashima, RAS mutation, Tumor Burden, GAME, CERR, and Glasgow Prognostic score, Basingstoke Index) were evaluated by likelihood ratio (LR) χ2, linear trend (LT) χ2 and Akaike Information Criterion (AIC) for their predictive value regarding overall survival (OS) and recurrence free survival (RFS).
Among 150 patients, median RFS was 9 (2–124) months with a 5-year RFS rate of 10%. Median OS was 39 (4–131) months with a 5-year OS rate of 32%. For RFS and OS, the Nagashima score showed the best prognostic ability (LT χ2 3.00, LR χ2 9.39, AIC 266.66 and LT χ2 2.91, LR χ2 20.91, 290.36).
The Nagashima score showed the best prognostic stratification to predict recurrence as well as survival, and therefore might be considered when evaluating patients with recCRLM for repeat hepatectomy.</description><identifier>ISSN: 1365-182X</identifier><identifier>EISSN: 1477-2574</identifier><identifier>DOI: 10.1016/j.hpb.2023.06.016</identifier><identifier>PMID: 37438185</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><ispartof>HPB (Oxford, England), 2023-11, Vol.25 (11), p.1354-1363</ispartof><rights>2023 International Hepato-Pancreato-Biliary Association Inc.</rights><rights>Copyright © 2023 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-316095a8a41388cbc2aec32a2790a854e0885eb1b6d591d8362d1a3df8bb6d693</citedby><cites>FETCH-LOGICAL-c353t-316095a8a41388cbc2aec32a2790a854e0885eb1b6d591d8362d1a3df8bb6d693</cites><orcidid>0000-0003-3088-1171 ; 0000-0002-5138-4214 ; 0000-0003-4455-5676</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37438185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Joechle, Katharina</creatorcontrib><creatorcontrib>Amygdalos, Iakovos</creatorcontrib><creatorcontrib>Schmidt, Felix</creatorcontrib><creatorcontrib>Bednarsch, Jan</creatorcontrib><creatorcontrib>Chrysos, Alexandros</creatorcontrib><creatorcontrib>Meister, Franziska A.</creatorcontrib><creatorcontrib>Czigany, Zoltan</creatorcontrib><creatorcontrib>Heise, Daniel</creatorcontrib><creatorcontrib>Berres, Marie-Luise</creatorcontrib><creatorcontrib>Bruners, Philipp</creatorcontrib><creatorcontrib>Ulmer, Tom F.</creatorcontrib><creatorcontrib>Neumann, Ulf P.</creatorcontrib><creatorcontrib>Lang, Sven A.</creatorcontrib><title>Value of prognostic scoring systems in the era of multimodal therapy for recurrent colorectal liver metastases</title><title>HPB (Oxford, England)</title><addtitle>HPB (Oxford)</addtitle><description>Various predictive scoring systems have been developed to estimate outcomes of patients undergoing surgery for colorectal liver metastases (CRLM). However, data regarding their effectiveness in recurrent CRLM (recCRLM) are very limited.
Patients who underwent repeat hepatectomy for recCRLM at the University Hospital RWTH Aachen, Germany from 2010 to 2021 were included. Nine predictive scoring systems (Fong's, Nordlinger, Nagashima, RAS mutation, Tumor Burden, GAME, CERR, and Glasgow Prognostic score, Basingstoke Index) were evaluated by likelihood ratio (LR) χ2, linear trend (LT) χ2 and Akaike Information Criterion (AIC) for their predictive value regarding overall survival (OS) and recurrence free survival (RFS).
Among 150 patients, median RFS was 9 (2–124) months with a 5-year RFS rate of 10%. Median OS was 39 (4–131) months with a 5-year OS rate of 32%. For RFS and OS, the Nagashima score showed the best prognostic ability (LT χ2 3.00, LR χ2 9.39, AIC 266.66 and LT χ2 2.91, LR χ2 20.91, 290.36).
The Nagashima score showed the best prognostic stratification to predict recurrence as well as survival, and therefore might be considered when evaluating patients with recCRLM for repeat hepatectomy.</description><issn>1365-182X</issn><issn>1477-2574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUhoMoOo4-gBvJ0k1rLr2kuJLBGwy4UXEX0vR0JkPbjEk6MG9vyqhLIZDk5_sPnA-hK0pSSmhxu0nX2zplhPGUFGlMjtCMZmWZsLzMjuObF3lCBfs8Q-febwhhsVadojNeZlxQkc_Q8KG6EbBt8dbZ1WB9MBp7bZ0ZVtjvfYDeYzPgsAYMTk1gP3bB9LZR3ZQ6td3j1jrsQI_OwRCwtp2NvxCBzuzA4R6C8vGAv0Anreo8XP7cc_T--PC2eE6Wr08vi_tlonnOQ8JpQapcCZVRLoSuNVOgOVOsrIgSeQZEiBxqWhdNXtFG8II1VPGmFXWMiorP0c1hbtzqawQfZG-8hq5TA9jRSxYrooyWJpQeUO2s9w5auXWmV24vKZGTZrmRUbOcNEtSyJjEzvXP-LHuoflr_HqNwN0BgLjkzoCTXhsYNDRmMiMba_4Z_w2zEY-Q</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Joechle, Katharina</creator><creator>Amygdalos, Iakovos</creator><creator>Schmidt, Felix</creator><creator>Bednarsch, Jan</creator><creator>Chrysos, Alexandros</creator><creator>Meister, Franziska A.</creator><creator>Czigany, Zoltan</creator><creator>Heise, Daniel</creator><creator>Berres, Marie-Luise</creator><creator>Bruners, Philipp</creator><creator>Ulmer, Tom F.</creator><creator>Neumann, Ulf P.</creator><creator>Lang, Sven A.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3088-1171</orcidid><orcidid>https://orcid.org/0000-0002-5138-4214</orcidid><orcidid>https://orcid.org/0000-0003-4455-5676</orcidid></search><sort><creationdate>20231101</creationdate><title>Value of prognostic scoring systems in the era of multimodal therapy for recurrent colorectal liver metastases</title><author>Joechle, Katharina ; Amygdalos, Iakovos ; Schmidt, Felix ; Bednarsch, Jan ; Chrysos, Alexandros ; Meister, Franziska A. ; Czigany, Zoltan ; Heise, Daniel ; Berres, Marie-Luise ; Bruners, Philipp ; Ulmer, Tom F. ; Neumann, Ulf P. ; Lang, Sven A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-316095a8a41388cbc2aec32a2790a854e0885eb1b6d591d8362d1a3df8bb6d693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joechle, Katharina</creatorcontrib><creatorcontrib>Amygdalos, Iakovos</creatorcontrib><creatorcontrib>Schmidt, Felix</creatorcontrib><creatorcontrib>Bednarsch, Jan</creatorcontrib><creatorcontrib>Chrysos, Alexandros</creatorcontrib><creatorcontrib>Meister, Franziska A.</creatorcontrib><creatorcontrib>Czigany, Zoltan</creatorcontrib><creatorcontrib>Heise, Daniel</creatorcontrib><creatorcontrib>Berres, Marie-Luise</creatorcontrib><creatorcontrib>Bruners, Philipp</creatorcontrib><creatorcontrib>Ulmer, Tom F.</creatorcontrib><creatorcontrib>Neumann, Ulf P.</creatorcontrib><creatorcontrib>Lang, Sven A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>HPB (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joechle, Katharina</au><au>Amygdalos, Iakovos</au><au>Schmidt, Felix</au><au>Bednarsch, Jan</au><au>Chrysos, Alexandros</au><au>Meister, Franziska A.</au><au>Czigany, Zoltan</au><au>Heise, Daniel</au><au>Berres, Marie-Luise</au><au>Bruners, Philipp</au><au>Ulmer, Tom F.</au><au>Neumann, Ulf P.</au><au>Lang, Sven A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of prognostic scoring systems in the era of multimodal therapy for recurrent colorectal liver metastases</atitle><jtitle>HPB (Oxford, England)</jtitle><addtitle>HPB (Oxford)</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>25</volume><issue>11</issue><spage>1354</spage><epage>1363</epage><pages>1354-1363</pages><issn>1365-182X</issn><eissn>1477-2574</eissn><abstract>Various predictive scoring systems have been developed to estimate outcomes of patients undergoing surgery for colorectal liver metastases (CRLM). However, data regarding their effectiveness in recurrent CRLM (recCRLM) are very limited.
Patients who underwent repeat hepatectomy for recCRLM at the University Hospital RWTH Aachen, Germany from 2010 to 2021 were included. Nine predictive scoring systems (Fong's, Nordlinger, Nagashima, RAS mutation, Tumor Burden, GAME, CERR, and Glasgow Prognostic score, Basingstoke Index) were evaluated by likelihood ratio (LR) χ2, linear trend (LT) χ2 and Akaike Information Criterion (AIC) for their predictive value regarding overall survival (OS) and recurrence free survival (RFS).
Among 150 patients, median RFS was 9 (2–124) months with a 5-year RFS rate of 10%. Median OS was 39 (4–131) months with a 5-year OS rate of 32%. For RFS and OS, the Nagashima score showed the best prognostic ability (LT χ2 3.00, LR χ2 9.39, AIC 266.66 and LT χ2 2.91, LR χ2 20.91, 290.36).
The Nagashima score showed the best prognostic stratification to predict recurrence as well as survival, and therefore might be considered when evaluating patients with recCRLM for repeat hepatectomy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37438185</pmid><doi>10.1016/j.hpb.2023.06.016</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-3088-1171</orcidid><orcidid>https://orcid.org/0000-0002-5138-4214</orcidid><orcidid>https://orcid.org/0000-0003-4455-5676</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1365-182X |
| ispartof | HPB (Oxford, England), 2023-11, Vol.25 (11), p.1354-1363 |
| issn | 1365-182X 1477-2574 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2836875749 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| title | Value of prognostic scoring systems in the era of multimodal therapy for recurrent colorectal liver metastases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T17%3A10%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Value%20of%20prognostic%20scoring%20systems%20in%20the%20era%20of%20multimodal%20therapy%20for%20recurrent%20colorectal%20liver%20metastases&rft.jtitle=HPB%20(Oxford,%20England)&rft.au=Joechle,%20Katharina&rft.date=2023-11-01&rft.volume=25&rft.issue=11&rft.spage=1354&rft.epage=1363&rft.pages=1354-1363&rft.issn=1365-182X&rft.eissn=1477-2574&rft_id=info:doi/10.1016/j.hpb.2023.06.016&rft_dat=%3Cproquest_cross%3E2836875749%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2836875749&rft_id=info:pmid/37438185&rft_els_id=S1365182X23005713&rfr_iscdi=true |